{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:48:23Z","timestamp":1791204503512,"version":"4.2.0"},"reference-count":93,"publisher":"American Chemical Society (ACS)","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2004,8,1]]},"DOI":"10.1021\/bi036044c","type":"journal-article","created":{"date-parts":[[2004,8,24]],"date-time":"2004-08-24T04:24:45Z","timestamp":1093321485000},"page":"10930-10943","source":"Crossref","is-referenced-by-count":117,"title":["Membrane-Insertion Fragments of Bcl-x<sub>L<\/sub>, Bax, and Bid"],"prefix":"10.1021","volume":"43","author":[{"given":"Ana J.","family":"Garc\u00eda-S\u00e1ez","sequence":"first","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat de Val\u00e8ncia, and Fundaci\u00f3n Valenciana de Investigaciones Biom\u00e9dicasConsejo Superior de Investigaciones Cient\u00edficas (FVIBCSIC), Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Mingarro","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat de Val\u00e8ncia, and Fundaci\u00f3n Valenciana de Investigaciones Biom\u00e9dicasConsejo Superior de Investigaciones Cient\u00edficas (FVIBCSIC), Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"P\u00e9rez-Pay\u00e1","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat de Val\u00e8ncia, and Fundaci\u00f3n Valenciana de Investigaciones Biom\u00e9dicasConsejo Superior de Investigaciones Cient\u00edficas (FVIBCSIC), Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Salgado","sequence":"additional","affiliation":[{"name":"Departament de Bioqu\u00edmica i Biologia Molecular, Universitat de Val\u00e8ncia, and Fundaci\u00f3n Valenciana de Investigaciones Biom\u00e9dicasConsejo Superior de Investigaciones Cient\u00edficas (FVIBCSIC), Val\u00e8ncia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2004,7,31]]},"reference":[{"key":"bi036044cb00001\/bi036044cb00001_1","volume-title":"Genes Dev. 13","author":"Gross A.","year":"1999"},{"key":"bi036044cb00002\/bi036044cb00002_1","volume-title":"Science 281, 1322\u22121326.","author":"Adams J. M.","year":"1998"},{"key":"bi036044cb00003\/bi036044cb00003_1","doi-asserted-by":"crossref","DOI":"10.1177\/40.12.1453000","volume":"40","author":"Monaghan P.","year":"1992","journal-title":"J. Histochem. Cytochem."},{"key":"bi036044cb00004\/bi036044cb00004_1","volume":"268","author":"Nguyen M.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00005\/bi036044cb00005_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(17)36960-0","volume":"269","author":"Janiak F.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00006\/bi036044cb00006_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1083\/jcb.200210084","volume":"160","author":"Kaufmann T.","year":"2003","journal-title":"J. Cell. Biol."},{"key":"bi036044cb00007\/bi036044cb00007_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.139.5.1281","volume":"139","author":"Wolter K. G.","year":"1997","journal-title":"J. Cell. Biol."},{"key":"bi036044cb00008\/bi036044cb00008_1","doi-asserted-by":"crossref","DOI":"10.1093\/emboj\/17.14.3878","volume":"17","author":"Gross A.","year":"1998","journal-title":"EMBO J."},{"key":"bi036044cb00009\/bi036044cb00009_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.144.5.891","volume":"144","author":"Desagher S.","year":"1999","journal-title":"J. Cell. Biol."},{"key":"bi036044cb00010\/bi036044cb00010_1","volume-title":"Bax, that accelerates programmed cell death, Cell 74, 609\u2212619.","author":"Oltvai Z. N.","year":"1993"},{"key":"bi036044cb00011\/bi036044cb00011_1","volume-title":"Science 275, 983\u2212986.","author":"Sattler M.","year":"1997"},{"key":"bi036044cb00012\/bi036044cb00012_1","volume-title":"BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis, Mol. Cell 8, 705\u2212711.","author":"Cheng E. H.","year":"2001"},{"key":"bi036044cb00013\/bi036044cb00013_1","volume-title":"Mol. Cell. Biol. 17, 7040\u22127046.","author":"Kelekar A.","year":"1997"},{"key":"bi036044cb00014\/bi036044cb00014_1","volume-title":"Cell 74, 597\u2212608.","author":"Boise L. H.","year":"1993"},{"key":"bi036044cb00015\/bi036044cb00015_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 94","author":"Hsu Y. T.","year":"1997"},{"key":"bi036044cb00016\/bi036044cb00016_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.143.1.207","volume":"143","author":"Goping I. S.","year":"1998","journal-title":"J. Cell. Biol."},{"key":"bi036044cb00017\/bi036044cb00017_1","doi-asserted-by":"crossref","DOI":"10.1093\/emboj\/18.9.2330","volume":"18","author":"Nechushtan A.","year":"1999","journal-title":"EMBO J."},{"key":"bi036044cb00018\/bi036044cb00018_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M306289200","volume":"278","author":"Yethon J. A.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00019\/bi036044cb00019_1","volume-title":"Mol. Cell. Biol. 20, 929\u2212935.","author":"Eskes R.","year":"2000"},{"key":"bi036044cb00020\/bi036044cb00020_1","volume-title":"Science 292, 727\u2212730.","author":"Wei M. C.","year":"2001"},{"key":"bi036044cb00021\/bi036044cb00021_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj3630547","volume":"363","author":"Roucou X.","year":"2002","journal-title":"Biochem. J."},{"key":"bi036044cb00022\/bi036044cb00022_1","volume-title":"Genes Dev. 14","author":"Wei M. C.","year":"2000"},{"key":"bi036044cb00023\/bi036044cb00023_1","volume-title":"Cell 94, 481\u2212490.","author":"Luo X.","year":"1998"},{"key":"bi036044cb00024\/bi036044cb00024_1","volume-title":"Cell 94, 491\u2212501.","author":"Li H.","year":"1998"},{"key":"bi036044cb00025\/bi036044cb00025_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj3450271","volume":"345","author":"Antonsson B.","year":"2000","journal-title":"Biochem. J."},{"key":"bi036044cb00026\/bi036044cb00026_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M010810200","volume":"276","author":"Antonsson B.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00027\/bi036044cb00027_1","volume-title":"Cell Death Differ. 7, 1166\u22121173.","author":"Korsmeyer S. J.","year":"2000"},{"key":"bi036044cb00028\/bi036044cb00028_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M208955200","volume":"278","author":"Cartron P. F.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00029\/bi036044cb00029_1","volume-title":"J. Cell Biol. 164, 1021\u22121032.","author":"Schinzel A.","year":"2004"},{"key":"bi036044cb00030\/bi036044cb00030_1","volume-title":"Nat. Cell Biol. 2, 754\u2212761.","author":"Lutter M.","year":"2000"},{"key":"bi036044cb00031\/bi036044cb00031_1","volume-title":"Cell 111, 331\u2212342.","author":"Kuwana T.","year":"2002"},{"key":"bi036044cb00032\/bi036044cb00032_1","volume-title":"Curr. Opin. Cell. Biol. 12, 414\u2212419.","author":"Crompton M.","year":"2000"},{"key":"bi036044cb00033\/bi036044cb00033_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj20020972","volume":"368","author":"Roucou X.","year":"2002","journal-title":"Biochem. J."},{"key":"bi036044cb00034\/bi036044cb00034_1","volume-title":"Nature 385, 353\u2212357.","author":"Minn A. J.","year":"1997"},{"key":"bi036044cb00035\/bi036044cb00035_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.274.31.21932","volume":"274","author":"Schendel S. L.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00036\/bi036044cb00036_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 94","author":"Schendel S. L.","year":"1997"},{"key":"bi036044cb00037\/bi036044cb00037_1","volume-title":"Science 277, 370\u2212372.","author":"Antonsson B.","year":"1997"},{"key":"bi036044cb00038\/bi036044cb00038_1","volume-title":"Science 281","author":"Marzo I.","year":"1998"},{"key":"bi036044cb00039\/bi036044cb00039_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 95","author":"Narita M.","year":"1998"},{"key":"bi036044cb00040\/bi036044cb00040_1","volume-title":"Nature 399, 483\u2212487.","author":"Shimizu S.","year":"1999"},{"key":"bi036044cb00041\/bi036044cb00041_1","volume-title":"Oncogene 19, 329\u2212336.","author":"Brenner C.","year":"2000"},{"key":"bi036044cb00042\/bi036044cb00042_1","first-page":"69","volume":"162","author":"Zong W. X.","year":"2003","journal-title":"J. Cell. Biol."},{"key":"bi036044cb00043\/bi036044cb00043_1","volume":"277","author":"Nutt L. K.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00044\/bi036044cb00044_1","volume-title":"Science 300, 135\u2212139.","author":"Scorrano L.","year":"2003"},{"key":"bi036044cb00045\/bi036044cb00045_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 97","author":"Shimizu S.","year":"2000"},{"key":"bi036044cb00046\/bi036044cb00046_1","volume":"18","author":"Minn A. J.","year":"1999","journal-title":"EMBO J."},{"key":"bi036044cb00047\/bi036044cb00047_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1023\/A:1005508311495","volume":"32","author":"Smaili S. S.","year":"2000","journal-title":"J. Bioenerg. Biomembr."},{"key":"bi036044cb00048\/bi036044cb00048_1","volume-title":"A role for calcium in Bcl-2 action? Biochimie 84, 195\u2212201","author":"Pinton P.","year":"2002"},{"key":"bi036044cb00049\/bi036044cb00049_1","volume-title":"Nature 381, 335\u2212341.","author":"Muchmore S. W.","year":"1996"},{"key":"bi036044cb00050\/bi036044cb00050_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.44.27886","volume":"272","author":"Aritomi M.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00051\/bi036044cb00051_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 98","author":"Petros A. M.","year":"2001"},{"key":"bi036044cb00052\/bi036044cb00052_1","volume-title":"Cell 103, 645\u2212654.","author":"Suzuki M.","year":"2000"},{"key":"bi036044cb00053\/bi036044cb00053_1","volume-title":"Cell 96, 625\u2212634.","author":"McDonnell J. M.","year":"1999"},{"key":"bi036044cb00054\/bi036044cb00054_1","volume-title":"Cell 96, 615\u2212624.","author":"Chou J. J.","year":"1999"},{"key":"bi036044cb00055\/bi036044cb00055_1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.bb.24.060195.003143","volume":"24","author":"Cramer W. A.","year":"1995","journal-title":"Rev. Biophys. Biomol. Struct."},{"key":"bi036044cb00056\/bi036044cb00056_1","doi-asserted-by":"crossref","unstructured":"Stroud, R. M., Reiling, K., Wiener, M., and Freymann, D. (1998) Ion-channel-forming colicins,Curr. Opin. Struct. Biol. 8, 525\u2212533.","DOI":"10.1016\/S0959-440X(98)80132-2"},{"key":"bi036044cb00057\/bi036044cb00057_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 94","author":"Schlesinger P. H.","year":"1997"},{"key":"bi036044cb00058\/bi036044cb00058_1","volume-title":"Nat. Cell Biol. 2, 553\u2212555.","author":"Saito M.","year":"2000"},{"key":"bi036044cb00059\/bi036044cb00059_1","doi-asserted-by":"crossref","DOI":"10.1093\/emboj\/20.11.2690","volume":"20","author":"Pinton P.","year":"2001","journal-title":"EMBO J."},{"key":"bi036044cb00060\/bi036044cb00060_1","volume-title":"Apoptosis 7, 441\u2212447.","author":"Rudner J.","year":"2002"},{"key":"bi036044cb00061\/bi036044cb00061_1","volume":"277","author":"Nutt L. K.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00062\/bi036044cb00062_1","volume":"273","author":"Matsuyama S.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00063\/bi036044cb00063_1","volume-title":"Mol. Cell. Biol. 20, 1604\u22121615.","author":"Nouraini S.","year":"2000"},{"key":"bi036044cb00064\/bi036044cb00064_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj20031152","volume":"378","author":"Heimlich G.","year":"2004","journal-title":"Biochem. J."},{"key":"bi036044cb00065\/bi036044cb00065_1","volume-title":"Mol. Cell 14, 523\u2212529.","author":"Kim P. K.","year":"2004"},{"key":"bi036044cb00066\/bi036044cb00066_1","volume-title":"Magn. Reson. Chem. 42, 172\u2212179.","author":"Franzin C. M.","year":"2004"},{"key":"bi036044cb00067\/bi036044cb00067_1","volume-title":"Comput. Appl. Biosci. 10, 685\u2212686.","author":"Claros M. G.","year":"1994"},{"key":"bi036044cb00068\/bi036044cb00068_1","volume-title":"Protein Eng. 10, 673\u2212676.","author":"Cserzo M.","year":"1997"},{"key":"bi036044cb00069\/bi036044cb00069_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/protein\/10.1.1","volume":"10","author":"Nielsen H.","year":"1997","journal-title":"Protein Eng."},{"key":"bi036044cb00070\/bi036044cb00070_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.126.5.1127","volume":"126","author":"Nilsson I.","year":"1994","journal-title":"J. Cell. Biol."},{"key":"bi036044cb00071\/bi036044cb00071_1","volume":"284","author":"Nilsson I.","year":"1998","journal-title":"J. Mol. Biol."},{"key":"bi036044cb00072\/bi036044cb00072_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)53389-5","volume":"268","author":"Nilsson I. M.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00073\/bi036044cb00073_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M202935200","volume":"277","author":"Vilar M.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00074\/bi036044cb00074_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0014-5793(02)02511-5","volume":"516","author":"Nilsson I.","year":"2002","journal-title":"FEBS Lett."},{"key":"bi036044cb00075\/bi036044cb00075_1","volume":"271","author":"Whitley P.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00076\/bi036044cb00076_1","doi-asserted-by":"crossref","DOI":"10.1093\/emboj\/16.13.4049","volume":"16","author":"Schaad M. C.","year":"1997","journal-title":"EMBO J."},{"key":"bi036044cb00077\/bi036044cb00077_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(19)69848-0","volume":"256","author":"Bordier C.","year":"1981","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00078\/bi036044cb00078_1","doi-asserted-by":"crossref","DOI":"10.1016\/0022-2836(92)90934-C","volume":"225","author":"von Heijne G.","year":"1992","journal-title":"J. Mol. Biol."},{"key":"bi036044cb00079\/bi036044cb00079_1","doi-asserted-by":"crossref","DOI":"10.1016\/0022-2836(82)90515-0","volume":"157","author":"Kyte J.","year":"1982","journal-title":"J. Mol. Biol."},{"key":"bi036044cb00080\/bi036044cb00080_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1128\/MMBR.64.1.13-33.2000","volume":"64","author":"van Geest M.","year":"2000","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"bi036044cb00081\/bi036044cb00081_1","volume-title":"Nature 341, 456\u2212458.","author":"von Heijne G.","year":"1989"},{"key":"bi036044cb00082\/bi036044cb00082_1","volume":"274","author":"van Geest M.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00083\/bi036044cb00083_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.200303069","volume":"161","author":"Borgese N.","year":"2003","journal-title":"J. Cell Biol."},{"key":"bi036044cb00084\/bi036044cb00084_1","volume":"78","author":"Peremyslov V. V.","year":"2004","journal-title":"J. Viriol."},{"key":"bi036044cb00085\/bi036044cb00085_1","volume":"274","author":"Gross A.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi036044cb00086\/bi036044cb00086_1","volume-title":"Biochemistry 39, 11024\u221211033.","author":"Losonczi J. A.","year":"2000"},{"key":"bi036044cb00087\/bi036044cb00087_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1999.2657","volume":"288","author":"Monne M.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"bi036044cb00088\/bi036044cb00088_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1999.3183","volume":"293","author":"Monne M.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"bi036044cb00089\/bi036044cb00089_1","volume-title":"Cell Death Differ. 5, 372\u2212380.","author":"Schendel S. L.","year":"1998"},{"key":"bi036044cb00090\/bi036044cb00090_1","volume-title":"Biochimie 84, 465\u2212475.","author":"Zakharov S. D.","year":"2002"},{"key":"bi036044cb00091\/bi036044cb00091_1","volume":"279","author":"Gong X. M.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"bi036044cn00001\/bi036044cn00001_1","volume-title":"proteins of the Bcl-2 family","author":"Abbreviations"},{"key":"bi036044cn00002\/bi036044cn00002_1","volume-title":"http:\/\/bioweb.pasteur.fr\/seqanal\/interfaces\/toppred.html","author":"TopPred II"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi036044c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T18:00:30Z","timestamp":1632160830000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi036044c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7,31]]},"references-count":93,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2004,8,1]]}},"alternative-id":["10.1021\/bi036044c"],"URL":"https:\/\/doi.org\/10.1021\/bi036044c","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7,31]]}}}