{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:21:29Z","timestamp":1778610089678,"version":"3.51.4"},"reference-count":98,"publisher":"American Chemical Society (ACS)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2005,3,1]]},"DOI":"10.1021\/bi048777i","type":"journal-article","created":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T05:21:00Z","timestamp":1109654460000},"page":"3547-3561","source":"Crossref","is-referenced-by-count":25,"title":["Role of Activation Function Domain-1, DNA Binding, and Coactivator GRIP1 in the Expression of Partial Agonist Activity of Glucocorticoid Receptor\u2212Antagonist Complexes"],"prefix":"10.1021","volume":"44","author":[{"given":"Sehyung","family":"Cho","sequence":"first","affiliation":[{"name":"Steroid Hormones Section, NIDDK\/LMCB, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Blackford","sequence":"additional","affiliation":[{"name":"Steroid Hormones Section, NIDDK\/LMCB, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Stoney","family":"Simons","sequence":"additional","affiliation":[{"name":"Steroid Hormones Section, NIDDK\/LMCB, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2005,2,9]]},"reference":[{"key":"bi048777ib00001\/bi048777ib00001_1","doi-asserted-by":"crossref","DOI":"10.1016\/0022-4731(88)90025-8","volume":"31","author":"Waeber B.","year":"1988","journal-title":"J. Steroid Biochem."},{"key":"bi048777ib00002\/bi048777ib00002_1","volume":"48","author":"Cadepond F.","year":"1997","journal-title":"Rev. Med."},{"key":"bi048777ib00003\/bi048777ib00003_1","volume-title":"Science 245, 1351\u22121357.","author":"Baulieu E. E.","year":"1989"},{"key":"bi048777ib00004\/bi048777ib00004_1","volume":"321","author":"Crawford E. D.","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"bi048777ib00005\/bi048777ib00005_1","doi-asserted-by":"crossref","DOI":"10.1210\/edrv-11-4-578","volume":"11","author":"Jordan V. C.","year":"1990","journal-title":"Endocr. Rev."},{"key":"bi048777ib00006\/bi048777ib00006_1","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.10.8.8666168","volume":"10","author":"Sato M.","year":"1996","journal-title":"FASEB J."},{"key":"bi048777ib00007\/bi048777ib00007_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-5793(02)02929-0","volume":"523","author":"Karvonen U.","year":"2002","journal-title":"FEBS Lett."},{"key":"bi048777ib00008\/bi048777ib00008_1","volume-title":"Steroid Sterol Horm. Act. 251\u2212268.","author":"Simons S. S., Jr.","year":"1987"},{"key":"bi048777ib00009\/bi048777ib00009_1","volume-title":"Mol. Endocrinol. 13, 2108\u22122121.","author":"Szapary D.","year":"1999"},{"key":"bi048777ib00010\/bi048777ib00010_1","volume":"275","author":"Chen S.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00011\/bi048777ib00011_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.48.30576","volume":"271","author":"Szapary D.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00012\/bi048777ib00012_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0960-0760(99)00021-7","volume":"68","author":"Sarlis N. J.","year":"1999","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"bi048777ib00013\/bi048777ib00013_1","volume":"277","author":"He Y.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00014\/bi048777ib00014_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2004.04.007","volume":"91","author":"Wang Q.","year":"2004","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"bi048777ib00015\/bi048777ib00015_1","volume-title":"Mol. Endocrinol. 15, 255\u2212270.","author":"Giannoukos G.","year":"2001"},{"key":"bi048777ib00016\/bi048777ib00016_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 99","author":"Liu Z.","year":"2002"},{"key":"bi048777ib00017\/bi048777ib00017_1","volume-title":"(Maywood) 227, 969\u2212980.","author":"Leonhardt S. A.","year":"2002"},{"key":"bi048777ib00018\/bi048777ib00018_1","volume-title":"TIPS 24, 253\u2212259.","author":"Simons S. S., Jr.","year":"2003"},{"key":"bi048777ib00019\/bi048777ib00019_1","volume-title":"Endocrinology 130, 2106\u22122112.","author":"Oshima H.","year":"1992"},{"key":"bi048777ib00020\/bi048777ib00020_1","volume-title":"Mol. Endocrinol. 6, 416\u2212428.","author":"Oshima H.","year":"1992"},{"key":"bi048777ib00021\/bi048777ib00021_1","volume-title":"Endocrinology 130, 3492\u22123502.","author":"Szapary D.","year":"1992"},{"key":"bi048777ib00022\/bi048777ib00022_1","volume":"276","author":"Song L.-N.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00023\/bi048777ib00023_1","volume-title":"Mol. Endocrinol. 14, 1010\u22121027.","author":"Kaul S.","year":"2000"},{"key":"bi048777ib00024\/bi048777ib00024_1","volume":"277","author":"Kaul S.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00025\/bi048777ib00025_1","volume-title":"Mol. Cell. Endocrinol. 199, 129\u2212142.","author":"Chen S.","year":"2003"},{"key":"bi048777ib00026\/bi048777ib00026_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.27.17138","volume":"273","author":"Barsalou A.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00027\/bi048777ib00027_1","volume-title":"Nat. Struct. Biol. 9, 359\u2212364.","author":"Shiau A. K.","year":"2002"},{"key":"bi048777ib00028\/bi048777ib00028_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M212711200","volume":"278","author":"Kauppi B.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00029\/bi048777ib00029_1","volume-title":"Functional analysis of R651 mutations in the putative helix 6 of rat glucocorticoid receptors. Mol. Cell. Endocrinol. 158, 117\u2212130","author":"Huang Y.","year":"1999"},{"key":"bi048777ib00030\/bi048777ib00030_1","volume-title":"Biochem. Biophys. Res. Commun. 86, 793\u2212800.","author":"Simons S. S., Jr.","year":"1979"},{"key":"bi048777ib00031\/bi048777ib00031_1","volume-title":"Mol. Pharmacol. 54, 105\u2212112.","author":"Barkhem T.","year":"1998"},{"key":"bi048777ib00032\/bi048777ib00032_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm00401a015","volume":"31","author":"Ojasoo T.","year":"1988","journal-title":"J. Med. Chem."},{"key":"bi048777ib00033\/bi048777ib00033_1","volume-title":"Science 295, 2465\u22122468.","author":"Shang Y.","year":"2002"},{"key":"bi048777ib00034\/bi048777ib00034_1","volume":"264","author":"Simons S. S., Jr.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00035\/bi048777ib00035_1","volume":"267","author":"Allan G. F.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00036\/bi048777ib00036_1","volume-title":"Nature 389, 753\u2212758.","author":"Brzozowski A. M.","year":"1997"},{"key":"bi048777ib00037\/bi048777ib00037_1","volume-title":"Nature 392, 885\u2212888.","author":"Lefstin J. A.","year":"1998"},{"key":"bi048777ib00038\/bi048777ib00038_1","volume-title":"Nature 377, 451\u2212454.","author":"Kurokawa R.","year":"1995"},{"key":"bi048777ib00039\/bi048777ib00039_1","volume-title":"Mol. Endocrinol. 16, 469\u2212486.","author":"Hall J. M.","year":"2002"},{"key":"bi048777ib00040\/bi048777ib00040_1","volume-title":"Mol. Endocrinol. 15, 1114\u221211126.","author":"Wood J. R.","year":"2001"},{"key":"bi048777ib00041\/bi048777ib00041_1","volume-title":"Mol. Cell. Biol. 19, 3073\u22123085.","author":"Mouchon A.","year":"1999"},{"key":"bi048777ib00042\/bi048777ib00042_1","volume-title":"Science 269","author":"Petersen J. M.","year":"1995"},{"key":"bi048777ib00043\/bi048777ib00043_1","doi-asserted-by":"crossref","DOI":"10.1002\/j.1460-2075.1993.tb06151.x","volume":"12","author":"Myrset A. H.","year":"1993","journal-title":"EMBO J."},{"key":"bi048777ib00044\/bi048777ib00044_1","volume-title":"Cell 66, 317\u2212326.","author":"Kerppola T. K.","year":"1991"},{"key":"bi048777ib00045\/bi048777ib00045_1","volume":"284","author":"Holmbeck S. M. A.","year":"1998","journal-title":"J. Mol. Biol."},{"key":"bi048777ib00046\/bi048777ib00046_1","volume":"247","author":"van Tilborg M. A. A.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"bi048777ib00047\/bi048777ib00047_1","volume-title":"Mol. Endocrinol. 10, 1444\u22121456.","author":"Staal A.","year":"1996"},{"key":"bi048777ib00048\/bi048777ib00048_1","volume":"274","author":"Kumar R.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00049\/bi048777ib00049_1","volume-title":"Mol. Endocrinol. 17, 1738\u22121750.","author":"Geserick C.","year":"2003"},{"key":"bi048777ib00050\/bi048777ib00050_1","volume":"9","author":"Meyer M.-E.","year":"1990","journal-title":"EMBO J."},{"key":"bi048777ib00051\/bi048777ib00051_1","doi-asserted-by":"crossref","DOI":"10.1093\/emboj\/cdg023","volume":"22","author":"Metzger E.","year":"2003","journal-title":"EMBO J."},{"key":"bi048777ib00052\/bi048777ib00052_1","volume-title":"Cell 59, 477\u2212487.","author":"Tora L.","year":"1989"},{"key":"bi048777ib00053\/bi048777ib00053_1","doi-asserted-by":"crossref","DOI":"10.1002\/j.1460-2075.1990.tb07469.x","volume":"9","author":"Berry M.","year":"1990","journal-title":"EMBO J."},{"key":"bi048777ib00054\/bi048777ib00054_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.270.16.9535","volume":"270","author":"Metzger D.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00055\/bi048777ib00055_1","volume":"271","author":"McInerney E. M.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00056\/bi048777ib00056_1","volume-title":"Mol. Endocrinol. 11, 657\u2212666.","author":"Smith C. L.","year":"1997"},{"key":"bi048777ib00057\/bi048777ib00057_1","first-page":"30","volume":"8","author":"Tzukerman M. T.","year":"1994","journal-title":"Mol. Endocrinol."},{"key":"bi048777ib00058\/bi048777ib00058_1","doi-asserted-by":"crossref","DOI":"10.1002\/j.1460-2075.1989.tb03604.x","volume":"8","author":"Tora L.","year":"1989","journal-title":"EMBO J."},{"key":"bi048777ib00059\/bi048777ib00059_1","doi-asserted-by":"crossref","unstructured":"Webb, P., Nguyen, P., Shinsako, J., Anderson, C., Feng, W., Nguyen, M. P., Chen, D., Huang, S. M., Subramanian, S., McKinerney, E., Katzenellenbogen, B. S., Stallcup, M. R., and Kushner, P. J. (1998) Estrogen receptor activation function 1 works by binding p160 coactivator proteins,Mol. Endocrinol.12, 1605\u22121618.","DOI":"10.1210\/mend.12.10.0185"},{"key":"bi048777ib00060\/bi048777ib00060_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.20.12101","volume":"273","author":"Onate S. A.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00061\/bi048777ib00061_1","volume-title":"Mol. Endocrinol. (accepted for publica-tion).","author":"Cho S.","year":"2004"},{"key":"bi048777ib00062\/bi048777ib00062_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.38.23986","volume":"272","author":"Modarress K. J.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00063\/bi048777ib00063_1","volume-title":"Mol. Endocrinol. 10, 1206\u22121213.","author":"Allan G. F.","year":"1996"},{"key":"bi048777ib00064\/bi048777ib00064_1","volume-title":"Endocrinology 140, 5828\u22125840.","author":"Wijayaratne A. L.","year":"1999"},{"key":"bi048777ib00065\/bi048777ib00065_1","doi-asserted-by":"crossref","DOI":"10.1021\/jo00329a024","volume":"46","author":"Pons M.","year":"1981","journal-title":"J. Org. Chem."},{"key":"bi048777ib00066\/bi048777ib00066_1","volume":"45","author":"Simons S. S., Jr.","year":"1980","journal-title":"J. Org. Chem."},{"key":"bi048777ib00067\/bi048777ib00067_1","volume-title":"Mol. Cell. Endocrinol. 162, 221\u2212234.","author":"Zeng H.","year":"2000"},{"key":"bi048777ib00068\/bi048777ib00068_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 78","author":"Simons S. S., Jr.","year":"1981"},{"key":"bi048777ib00069\/bi048777ib00069_1","volume":"262","author":"Simons S. S., Jr.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00070\/bi048777ib00070_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0092-8674(87)90753-7","volume":"49","author":"Hollenberg S. M.","year":"1987","journal-title":"Cell"},{"key":"bi048777ib00071\/bi048777ib00071_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 93","author":"Hong H.","year":"1996"},{"key":"bi048777ib00072\/bi048777ib00072_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0092-8674(02)00817-6","volume":"110","author":"Bledsoe R. K.","year":"2002","journal-title":"Cell"},{"key":"bi048777ib00073\/bi048777ib00073_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0960-0760(98)00118-6","volume":"67","author":"Plisov S. Y.","year":"1998","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"bi048777ib00074\/bi048777ib00074_1","doi-asserted-by":"crossref","DOI":"10.1093\/emboj\/17.2.507","volume":"17","author":"Voegel J. J.","year":"1998","journal-title":"EMBO J."},{"key":"bi048777ib00075\/bi048777ib00075_1","volume-title":"Mol. Endocrinol. 12, 302\u2212313.","author":"Ding X. F.","year":"1998"},{"key":"bi048777ib00076\/bi048777ib00076_1","volume-title":"Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA. Nature 324, 688\u2212691","author":"Willmann T.","year":"1986"},{"key":"bi048777ib00077\/bi048777ib00077_1","volume-title":"Mol. Endocrinol. 14","author":"Metivier R.","year":"2000"},{"key":"bi048777ib00078\/bi048777ib00078_1","volume-title":"Mol. Endocrinol. 16, 661\u2212673.","author":"Dotzlaw H.","year":"2002"},{"key":"bi048777ib00079\/bi048777ib00079_1","volume-title":"Mol. Endocrinol. 6","author":"Garcia T.","year":"1992"},{"key":"bi048777ib00080\/bi048777ib00080_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.47.29821","volume":"272","author":"Ikonen T.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00081\/bi048777ib00081_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 95","author":"Lavinsky R. M.","year":"1998"},{"key":"bi048777ib00082\/bi048777ib00082_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.12.6679","volume":"273","author":"Norris J. D.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00083\/bi048777ib00083_1","volume-title":"Mol. Cell. Biol. 19, 6164\u22126173.","author":"Ma H.","year":"1999"},{"key":"bi048777ib00084\/bi048777ib00084_1","volume-title":"Mol. Cell. Biol. 17, 2735\u22122744.","author":"Hong H.","year":"1997"},{"key":"bi048777ib00085\/bi048777ib00085_1","volume":"275","author":"Klein E. S.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00086\/bi048777ib00086_1","volume-title":"Glucocorticoid vs antiglucocorticoid activity:\u2009 can a single functional group modification of glucocorticoid steroids always convey antiglucocorticoid activity? Endocrinology 114, 2252\u22122263","author":"Lamontagne N.","year":"1984"},{"key":"bi048777ib00087\/bi048777ib00087_1","volume-title":"EMBO 18, 4608\u22124618.","author":"Pike A. C. W.","year":"1999"},{"key":"bi048777ib00088\/bi048777ib00088_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 94","author":"Grese T. A.","year":"1997"},{"key":"bi048777ib00089\/bi048777ib00089_1","volume-title":"Cell 95, 927\u2212937.","author":"Shiau A. K.","year":"1998"},{"key":"bi048777ib00090\/bi048777ib00090_1","volume-title":"Biochemistry 42, 9278\u22129287.","author":"Stanley T. B.","year":"2003"},{"key":"bi048777ib00091\/bi048777ib00091_1","volume-title":"Mol. Endocrinol. 18, 1376\u22121395.","author":"Wang Q.","year":"2004"},{"key":"bi048777ib00092\/bi048777ib00092_1","volume-title":"Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities. Genes Dev. 3, 1590\u22121601","author":"Schena M.","year":"1989"},{"key":"bi048777ib00093\/bi048777ib00093_1","volume":"258","author":"Simons S. S., Jr.","year":"1983","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00094\/bi048777ib00094_1","volume-title":"Endocrinology 122, 2990\u22122998.","author":"Miller P. A.","year":"1988"},{"key":"bi048777ib00095\/bi048777ib00095_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(19)49919-5","volume":"267","author":"Chakraborti P. K.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"bi048777ib00096\/bi048777ib00096_1","volume-title":"Biochemistry 23, 5376\u22125384.","author":"Reichman M. E.","year":"1984"},{"key":"bi048777ib00097\/bi048777ib00097_1","first-page":"100","volume":"155","author":"Xu M.","year":"1999","journal-title":"Mol. Cell. Endo."},{"key":"bi048777in00001\/bi048777in00001_1","volume-title":"GRs, glucocorticoid receptors","author":"Abbreviations"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi048777i","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T07:15:35Z","timestamp":1633245335000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi048777i"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,9]]},"references-count":98,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,3,1]]}},"alternative-id":["10.1021\/bi048777i"],"URL":"https:\/\/doi.org\/10.1021\/bi048777i","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,9]]}}}