{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:22:14Z","timestamp":1767961334368,"version":"3.49.0"},"reference-count":46,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2005,2,1]]},"DOI":"10.1021\/bi048851x","type":"journal-article","created":{"date-parts":[[2005,2,15]],"date-time":"2005-02-15T05:32:15Z","timestamp":1108445535000},"page":"2293-2304","source":"Crossref","is-referenced-by-count":85,"title":["Kinetic Characterization of Novel Pyrazole TGF-\u03b2 Receptor I Kinase Inhibitors and Their Blockade of the Epithelial\u2212Mesenchymal Transition"],"prefix":"10.1021","volume":"44","author":[{"given":"Sheng-Bin","family":"Peng","sequence":"first","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Xia","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Watkins","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold B.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Beight","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David K.","family":"Herron","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Jones","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Lampe","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"McMillen","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Mort","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Scott","family":"Sawyer","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Yingling","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2005,1,27]]},"reference":[{"key":"bi048851xb00001\/bi048851xb00001_1","volume-title":"Peptide, Growth Factors, and Their Receptors","author":"Roberts A. B.","year":"1990"},{"key":"bi048851xb00002\/bi048851xb00002_1","volume":"133","author":"Derynck R.","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"bi048851xb00003\/bi048851xb00003_1","first-page":"34","volume":"91","author":"Yue J.","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"bi048851xb00004\/bi048851xb00004_1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.biochem.67.1.753","volume":"67","author":"Massagu\u00e9 J.","year":"1998","journal-title":"Rev. Biochem."},{"key":"bi048851xb00005\/bi048851xb00005_1","volume-title":"Cell 71, 1003\u22121014.","author":"Wrana J. L.","year":"1992"},{"key":"bi048851xb00006\/bi048851xb00006_1","volume-title":"Nature 370, 341\u2212347.","author":"Wrana J. L.","year":"1994"},{"key":"bi048851xb00007\/bi048851xb00007_1","volume-title":"Science 264, 101\u2212104.","author":"Dijke P.","year":"1994"},{"key":"bi048851xb00008\/bi048851xb00008_1","volume-title":"Trends Genet. 12, 493\u2212496.","author":"Wrana J. L.","year":"1996"},{"key":"bi048851xb00009\/bi048851xb00009_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0968-0004(99)01525-X","volume":"25","author":"Dijke P.","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"bi048851xb00010\/bi048851xb00010_1","unstructured":"Massagu\u00e9, J., and Chen, Y.G. (2000) Controlling TGF-\u03b2 signaling,Genes Dev.14, 627\u2212644."},{"key":"bi048851xb00011\/bi048851xb00011_1","volume-title":"Nat. Genet. 29, 117\u2212129.","author":"Derynck R.","year":"2001"},{"key":"bi048851xb00012\/bi048851xb00012_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrc1208","volume":"3","author":"Siegel P. M.","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"bi048851xb00013\/bi048851xb00013_1","volume-title":"Acta Anat. 154, 8\u221220.","author":"Hay E. D.","year":"1995"},{"key":"bi048851xb00014\/bi048851xb00014_1","doi-asserted-by":"crossref","DOI":"10.1159\/000147849","volume":"156","author":"Boyer B.","year":"1996","journal-title":"Acta Anat."},{"key":"bi048851xb00015\/bi048851xb00015_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1524-4741.1996.tb00076.x","volume":"2","author":"Gilles C.","year":"1996","journal-title":"Breast J."},{"key":"bi048851xb00016\/bi048851xb00016_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrc822","volume":"2","author":"Thiery J. P.","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"bi048851xb00017\/bi048851xb00017_1","volume-title":"Curr. Biol. 8, 1243\u22121252.","author":"Oft M.","year":"1998"},{"key":"bi048851xb00018\/bi048851xb00018_1","volume-title":"Cancer Res. 59, 5041\u22125046.","author":"Bandyopadhyay A.","year":"1999"},{"key":"bi048851xb00019\/bi048851xb00019_1","volume-title":"Cell 103, 295\u2212309.","author":"Massagu\u00e9 J.","year":"2000"},{"key":"bi048851xb00020\/bi048851xb00020_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0002-9440(10)62503-5","volume":"159","author":"Stahl P. J.","year":"2001","journal-title":"Am. J. Pathol."},{"key":"bi048851xb00021\/bi048851xb00021_1","volume":"159","author":"Yang J.","year":"2001","journal-title":"Am. J. Pathol."},{"key":"bi048851xb00022\/bi048851xb00022_1","volume":"270","author":"Chen R. H.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi048851xb00023\/bi048851xb00023_1","doi-asserted-by":"crossref","unstructured":"Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C. H., and Miyazono, K. (1993) Cloning of a TGF \u03b2 type I receptor that forms a heteromeric complex with the TGF \u03b2 type II receptor,Cell 75, 681\u2212692.","DOI":"10.1016\/0092-8674(93)90489-D"},{"key":"bi048851xb00024\/bi048851xb00024_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.44.27678","volume":"272","author":"Abdollah S.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bi048851xb00025\/bi048851xb00025_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.272.44.28107","volume":"272","author":"Souchelnytskyi S.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bi048851xb00026\/bi048851xb00026_1","doi-asserted-by":"crossref","DOI":"10.1002\/j.1460-2075.1995.tb07214.x","volume":"14","author":"Wieser R.","year":"1995","journal-title":"EMBO J."},{"key":"bi048851xb00027\/bi048851xb00027_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1124\/mol.62.1.58","volume":"62","author":"Laping N. J.","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"bi048851xb00028\/bi048851xb00028_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1124\/mol.62.1.65","volume":"62","author":"Inman G. J.","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"bi048851xb00029\/bi048851xb00029_1","volume-title":"ALK5, and ALK7, Mol. Pharmacol. 65, 744\u2212752.","author":"DaCosta B. S.","year":"2004"},{"key":"bi048851xb00030\/bi048851xb00030_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm0205705","volume":"46","author":"Sawyer J. S.","year":"2003","journal-title":"J. Med. Chem."},{"key":"bi048851xb00031\/bi048851xb00031_1","volume":"14","author":"Sawyer J. S.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"bi048851xb00032\/bi048851xb00032_1","volume":"14","author":"Li H. Y.","year":"2004","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"bi048851xb00033\/bi048851xb00033_1","volume-title":"Curr. Opin. Drug Discovery Dev. 7, 437\u2212445.","author":"Singh J.","year":"2004"},{"key":"bi048851xb00034\/bi048851xb00034_1","volume-title":"Cell 11, 779\u2212791.","author":"Tsukazaki T.","year":"1998"},{"key":"bi048851xb00035\/bi048851xb00035_1","volume":"13","author":"Singh J.","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"bi048851xb00036\/bi048851xb00036_1","volume-title":"Curr. Opin. Biotechnol. 6, 657\u2212661.","author":"Lee J. C.","year":"1995"},{"key":"bi048851xb00037\/bi048851xb00037_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrd1066","volume":"2","author":"Dancey J.","year":"2003","journal-title":"Nat. Rev. Drug Discovery"},{"key":"bi048851xb00038\/bi048851xb00038_1","volume-title":"Curr. Opin. Chem. Biol. 1, 219\u2212226.","author":"Taylor S.","year":"1997"},{"key":"bi048851xb00039\/bi048851xb00039_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrd1500","volume":"3","author":"Swinney D. C.","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"key":"bi048851xb00040\/bi048851xb00040_1","volume":"23","author":"Shingo M.","year":"2004","journal-title":"EMBO J."},{"key":"bi048851xb00041\/bi048851xb00041_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.127.6.2021","volume":"127","author":"Miettinen J. P.","year":"1994","journal-title":"J. Cell. Biol."},{"key":"bi048851xb00042\/bi048851xb00042_1","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.112.24.4557","volume":"112","author":"Piek E.","year":"1999","journal-title":"J. Cell Sci."},{"key":"bi048851xb00043\/bi048851xb00043_1","first-page":"50","volume":"68","author":"Ge R.","year":"2004","journal-title":"Biochem. Pharmacol."},{"key":"bi048851xb00044\/bi048851xb00044_1","volume-title":"Cell 86, 531\u2212542.","author":"Cui W.","year":"1996"},{"key":"bi048851xb00045\/bi048851xb00045_1","volume-title":"Biochemistry 43, 5698\u22125706.","author":"Ottesen J. J.","year":"2004"},{"key":"bi048851xn00001\/bi048851xn00001_1","volume-title":"transforming growth factor \u03b2","author":"Abbreviations"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi048851x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T10:04:30Z","timestamp":1634033070000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi048851x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,27]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,2,1]]}},"alternative-id":["10.1021\/bi048851x"],"URL":"https:\/\/doi.org\/10.1021\/bi048851x","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,27]]}}}