{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:09:49Z","timestamp":1760980189487},"reference-count":29,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2005,2,1]]},"DOI":"10.1021\/bi049231z","type":"journal-article","created":{"date-parts":[[2005,2,8]],"date-time":"2005-02-08T05:26:43Z","timestamp":1107840403000},"page":"1846-1855","source":"Crossref","is-referenced-by-count":19,"title":["Photochromic Agents as Tools for Protein Structure Study:\u2009 Lapachenole Is a Photoaffinity Ligand of Cytochrome P450 3A4"],"prefix":"10.1021","volume":"44","author":[{"given":"Carlos A.","family":"Gartner","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195, Photonics Center, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, and Department of Chemistry, Instituto Tecnico Superior, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195, Photonics Center, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, and Department of Chemistry, Instituto Tecnico Superior, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiandi","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195, Photonics Center, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, and Department of Chemistry, Instituto Tecnico Superior, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph S.","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195, Photonics Center, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, and Department of Chemistry, Instituto Tecnico Superior, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilford","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195, Photonics Center, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, and Department of Chemistry, Instituto Tecnico Superior, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven P.","family":"Gygi","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195, Photonics Center, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, and Department of Chemistry, Instituto Tecnico Superior, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidney D.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, Washington 98195, Photonics Center, Boston University, 8 St. Mary's Street, Boston, Massachusetts 02215, and Department of Chemistry, Instituto Tecnico Superior, Lisbon, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2005,1,20]]},"reference":[{"key":"bi049231zb00001\/bi049231zb00001_1","volume-title":"in Cytochrome P450:\u2009 Structure, Mechanisms, and Biochemistry","author":"Guengerich F. P.","year":"1995"},{"key":"bi049231zb00002\/bi049231zb00002_1","volume-title":"Biochemistry 29, 11280\u221211292.","author":"Brian W. R.","year":"1990"},{"key":"bi049231zb00003\/bi049231zb00003_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00228-002-0537-3","volume":"58","author":"Wangensteen H.","year":"2003","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"bi049231zb00004\/bi049231zb00004_1","volume":"4","author":"Foster B. C.","year":"2001","journal-title":"J. Pharm. Pharm. Sci."},{"key":"bi049231zb00005\/bi049231zb00005_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1067\/mcp.2001.116892","volume":"70","author":"Offman E. M.","year":"2001","journal-title":"Clin. Pharmacol. Ther."},{"key":"bi049231zb00006\/bi049231zb00006_1","volume-title":"Curr. Drug Metab. 2, 215\u2212243.","author":"Kent U. M.","year":"2001"},{"key":"bi049231zb00007\/bi049231zb00007_1","volume":"275","author":"Chiba M.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"bi049231zb00008\/bi049231zb00008_1","volume-title":"Biochemistry 39, 4276\u22124287.","author":"Lightning L. K.","year":"2000"},{"key":"bi049231zb00009\/bi049231zb00009_1","volume-title":"Chem. 10, 671\u2212689.","author":"Gartner C. A.","year":"2003"},{"key":"bi049231zb00010\/bi049231zb00010_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)50310-0","volume":"254","author":"Swanson R. A.","year":"1979","journal-title":"J. Biol. Chem."},{"key":"bi049231zb00011\/bi049231zb00011_1","doi-asserted-by":"crossref","DOI":"10.1021\/cr9800816","volume":"100","author":"Tamai N.","year":"2000","journal-title":"Chem. Rev."},{"key":"bi049231zb00012\/bi049231zb00012_1","volume":"88","author":"Becker R. S.","year":"1966","journal-title":"J. Am. Chem. Soc."},{"key":"bi049231zb00013\/bi049231zb00013_1","doi-asserted-by":"crossref","DOI":"10.1021\/j100871a048","volume":"71","author":"Kolc J.","year":"1967","journal-title":"J. Phys. Chem."},{"key":"bi049231zb00014\/bi049231zb00014_1","volume-title":"Synthesis","author":"Alves G. B. C.","year":"1999"},{"key":"bi049231zb00015\/bi049231zb00015_1","volume-title":"Synthesis, 279\u2212282.","author":"Chauder B. A.","year":"1998"},{"key":"bi049231zb00016\/bi049231zb00016_1","volume-title":"Arch. Biochem. Biophys. 305, 123\u2212131.","author":"Gillam E. M.","year":"1993"},{"key":"bi049231zb00017\/bi049231zb00017_1","volume":"264","author":"Shen A. L.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"bi049231zb00018\/bi049231zb00018_1","volume-title":"NADPH\u2212cytochrome P450 reductase, and cytochrome b5, Arch. Biochem. Biophys. 348, 107\u2212115.","author":"Shaw P. M.","year":"1997"},{"key":"bi049231zb00019\/bi049231zb00019_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(20)82245-5","volume":"239","author":"Omura T.","year":"1964","journal-title":"J. Biol. Chem."},{"key":"bi049231zb00020\/bi049231zb00020_1","volume-title":"Protein Expression Purif. 22, 443\u2212454.","author":"Gartner C. A.","year":"2001"},{"key":"bi049231zb00021\/bi049231zb00021_1","volume-title":"Mol. Cryst. Liq. Cryst. Sci. Technol., Sect. A:\u2009 Mol. Cryst. Liq. Cryst. 298, 413\u2212420.","author":"Favaro G.","year":"1997"},{"key":"bi049231zb00022\/bi049231zb00022_1","volume":"40","author":"Padwa A.","year":"1975","journal-title":"J. Org. Chem."},{"key":"bi049231zb00023\/bi049231zb00023_1","volume-title":"Chem.-Biol. Interact. 48, 297\u2212315.","author":"Halpin R. A.","year":"1984"},{"key":"bi049231zb00024\/bi049231zb00024_1","volume-title":"Biochem. Pharmacol. 36, 441\u2212446.","author":"Ravindranath V.","year":"1987"},{"key":"bi049231zb00025\/bi049231zb00025_1","volume-title":"Biochem. Pharmacol. 45, 1323\u22121331.","author":"Bornheim L. M.","year":"1993"},{"key":"bi049231zb00026\/bi049231zb00026_1","volume-title":"Drug Metab. Dispos. 32, 1083\u22121091.","author":"McConn D. J.","year":"2004"},{"key":"bi049231zb00027\/bi049231zb00027_1","volume-title":"Biochemistry 35, 14530\u221214536.","author":"Martinis S. A.","year":"1996"},{"key":"bi049231zb00028\/bi049231zb00028_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 100","author":"Perera R.","year":"2003"},{"key":"bi049231zn00001\/bi049231zn00001_1","volume-title":"cytochrome P450 3A4","author":"Abbreviations"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi049231z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T01:25:55Z","timestamp":1678152355000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi049231z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,20]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,2,1]]}},"alternative-id":["10.1021\/bi049231z"],"URL":"https:\/\/doi.org\/10.1021\/bi049231z","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1,20]]}}}