{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:36:06Z","timestamp":1789803366799,"version":"4.0.1"},"reference-count":55,"publisher":"American Chemical Society (ACS)","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1021\/bi050235t","type":"journal-article","created":{"date-parts":[[2005,6,21]],"date-time":"2005-06-21T09:20:56Z","timestamp":1119345656000},"page":"9179-9187","source":"Crossref","is-referenced-by-count":31,"title":["Genetic Polymorphism and Expression of a Highly Potent Scorpion Depressant Toxin Enable Refinement of the Effects on Insect Na Channels and Illuminate the Key Role of Asn-58"],"prefix":"10.1021","volume":"44","author":[{"given":"David","family":"Strugatsky","sequence":"first","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Zilberberg","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Stankiewicz","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitza","family":"Ilan","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Turkov","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Pelhate","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gilles","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gurevitz","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat-Aviv 69978, Tel-Aviv, Israel, Department of Life Sciences, Ben Gurion University, Beer Sheva 84105, Israel, Biophysics Laboratory, Institute of General and Molecular Biology, N. Copernicus University, Torun, Poland, Laboratoire R\u00e9cepteurs et Canaux Ioniques Membranaires-UFR Sciences, Universit\u00e9 d'Angers, 2 Bd Lavoisier, F-49045 Angers Cedex, France, and D\u00e9partment d'Ing\u00e9nierie et d'Etudes des Prot\u00e9ines, CEA,..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2005,6,1]]},"reference":[{"key":"bi050235tb00001\/bi050235tb00001_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02106182","volume":"29","author":"Fontecilla-Camps J. C.","year":"1989","journal-title":"J. Mol. Evol."},{"key":"bi050235tb00002\/bi050235tb00002_1","volume-title":"FASEB J. 15, 1201\u22121205.","author":"Gurevitz M.","year":"2001"},{"key":"bi050235tb00003\/bi050235tb00003_1","volume-title":"J. Toxicol., Toxin Rev. 17, 131\u2212159.","author":"Gordon D.","year":"1998"},{"key":"bi050235tb00004\/bi050235tb00004_1","volume-title":"Eur. J. Biochem. 264, 287\u2212300.","author":"Possani L. D.","year":"1999"},{"key":"bi050235tb00005\/bi050235tb00005_1","volume-title":"Handbook of Neurotoxicology","author":"Martin-Eauclaire M.-F.","year":"1995"},{"key":"bi050235tb00006\/bi050235tb00006_1","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.1992.72.suppl_4.S15","volume":"72","author":"Catterall W. A.","year":"1992","journal-title":"Physiol. Rev."},{"key":"bi050235tb00007\/bi050235tb00007_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-6273(00)81133-2","volume":"26","author":"Catterall W. A.","year":"2000","journal-title":"Neuron"},{"key":"bi050235tb00008\/bi050235tb00008_1","volume-title":"Biochimie 82, 883\u2212892.","author":"Cestele S.","year":"2000"},{"key":"bi050235tb00009\/bi050235tb00009_1","volume-title":"Toxins and Signal Transduction","author":"Zlotkin E.","year":"1997"},{"key":"bi050235tb00010\/bi050235tb00010_1","volume-title":"Arch. Biochem. Biophys. 240, 877\u2212887.","author":"Zlotkin E.","year":"1985"},{"key":"bi050235tb00011\/bi050235tb00011_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.274.9.5769","volume":"274","author":"Froy O.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi050235tb00012\/bi050235tb00012_1","doi-asserted-by":"crossref","DOI":"10.1016\/0167-4838(82)90240-0","volume":"701","author":"Lester D.","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"bi050235tb00013\/bi050235tb00013_1","volume-title":"Biochemistry 31, 7622\u22127628.","author":"Gordon D.","year":"1992"},{"key":"bi050235tb00014\/bi050235tb00014_1","volume-title":"Biochemistry 30, 4814\u22124821.","author":"Zlotkin E.","year":"1991"},{"key":"bi050235tb00015\/bi050235tb00015_1","volume-title":"Life Sci. 61, 819\u2212830.","author":"Ben Khalifa R.","year":"1997"},{"key":"bi050235tb00016\/bi050235tb00016_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1432-1033.1997.93_1a.x","volume":"243","author":"Cestele S.","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"bi050235tb00017\/bi050235tb00017_1","volume-title":"Arch. Biochem. Biophys. 391, 197\u2212206.","author":"Ali S. A.","year":"2001"},{"key":"bi050235tb00018\/bi050235tb00018_1","volume-title":"Toxicon 35, 365\u2212382.","author":"Borchani L.","year":"1997"},{"key":"bi050235tb00019\/bi050235tb00019_1","volume-title":"FEBS Lett. 261, 423\u2212426.","author":"Kopeyan C.","year":"1990"},{"key":"bi050235tb00020\/bi050235tb00020_1","volume-title":"Eur. J. Biochem. 246, 496\u2212501.","author":"Nakagawa Y.","year":"1997"},{"key":"bi050235tb00021\/bi050235tb00021_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0965-1748(94)90118-X","volume":"24","author":"Moskowitz H.","year":"1994","journal-title":"Insect Biochem. Mol. Biol."},{"key":"bi050235tb00022\/bi050235tb00022_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0014-5793(97)01614-1","volume":"422","author":"Gershburg E.","year":"1998","journal-title":"FEBS Lett."},{"key":"bi050235tb00023\/bi050235tb00023_1","volume-title":"FEBS Lett. 537, 106\u2212110.","author":"Regev A.","year":"2003"},{"key":"bi050235tb00024\/bi050235tb00024_1","volume-title":"Gene 56, 125\u2212135.","author":"Rosenberg A. H.","year":"1987"},{"key":"bi050235tb00025\/bi050235tb00025_1","doi-asserted-by":"crossref","DOI":"10.1016\/0014-5793(90)81161-G","volume":"269","author":"Gurevitz M.","year":"1990","journal-title":"FEBS Lett."},{"key":"bi050235tb00026\/bi050235tb00026_1","volume-title":"Toxicon 29, 1155\u22121158.","author":"Zilberberg N.","year":"1991"},{"key":"bi050235tb00027\/bi050235tb00027_1","volume-title":"Protein Expression Purif. 9, 123\u2212131.","author":"Turkov M.","year":"1997"},{"key":"bi050235tb00028\/bi050235tb00028_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 72","author":"Grunstein M.","year":"1975"},{"key":"bi050235tb00029\/bi050235tb00029_1","volume-title":"Biochemistry 35, 10215\u221210222.","author":"Zilberberg N.","year":"1996"},{"key":"bi050235tb00030\/bi050235tb00030_1","volume":"27","author":"Reed L.","year":"1938","journal-title":"Am. J. Hyg."},{"key":"bi050235tb00031\/bi050235tb00031_1","doi-asserted-by":"crossref","DOI":"10.1046\/j.1471-4159.2000.0751735.x","volume":"75","author":"Gilles N.","year":"2000","journal-title":"J. Neurochem."},{"key":"bi050235tb00032\/bi050235tb00032_1","volume":"47","author":"Pichon Y.","year":"1967","journal-title":"J. Exp. Biol."},{"key":"bi050235tb00033\/bi050235tb00033_1","doi-asserted-by":"crossref","DOI":"10.1016\/0022-1910(82)90104-4","volume":"28","author":"Pelhate M.","year":"1982","journal-title":"J. Insect Physiol."},{"key":"bi050235tb00034\/bi050235tb00034_1","volume-title":"Arch. Insect Biochem. Physiol. 22, 55\u221273.","author":"Zlotkin E.","year":"1993"},{"key":"bi050235tb00035\/bi050235tb00035_1","doi-asserted-by":"crossref","DOI":"10.1016\/0005-2736(84)90379-1","volume":"778","author":"Gordon D.","year":"1984","journal-title":"Biochim. Biophys. Acta"},{"key":"bi050235tb00036\/bi050235tb00036_1","doi-asserted-by":"crossref","DOI":"10.1007\/PL00006457","volume":"48","author":"Froy O.","year":"1999","journal-title":"J. Mol. Evol."},{"key":"bi050235tb00037\/bi050235tb00037_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1432-1327.1998.2540044.x","volume":"254","author":"Moskowitz H.","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"bi050235tb00038\/bi050235tb00038_1","volume-title":"Neuron 21, 919\u2212931.","author":"Cestele S.","year":"1998"},{"key":"bi050235tb00039\/bi050235tb00039_1","volume":"18","author":"Karbat I.","year":"2004","journal-title":"FASEB J."},{"key":"bi050235tb00040\/bi050235tb00040_1","volume-title":"J. Gen. Physiol. 118, 291\u2212301.","author":"Cestele S.","year":"2001"},{"key":"bi050235tb00041\/bi050235tb00041_1","volume-title":"J. Insect Physiol. 42, 397\u2212405.","author":"Stankiewicz M.","year":"1996"},{"key":"bi050235tb00042\/bi050235tb00042_1","volume-title":"Pfluegers Arch. 406, 620\u2212628.","author":"Simard J. M.","year":"1986"},{"key":"bi050235tb00043\/bi050235tb00043_1","volume-title":"Pfluegers Arch. 397, 90\u221299.","author":"Hu S. L.","year":"1983"},{"key":"bi050235tb00044\/bi050235tb00044_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00580727","volume":"407","author":"Jonas P.","year":"1986","journal-title":"Pfluegers Arch."},{"key":"bi050235tb00045\/bi050235tb00045_1","first-page":"16","volume":"61","author":"Wang C.-G.","year":"2003","journal-title":"Pept. Res."},{"key":"bi050235tb00046\/bi050235tb00046_1","volume-title":"Neuron 12, 281\u2212294.","author":"Chahine M.","year":"1994"},{"key":"bi050235tb00047\/bi050235tb00047_1","volume":"108","author":"Chen L. Q.","year":"1996","journal-title":"J. Gen. Physiol."},{"key":"bi050235tb00048\/bi050235tb00048_1","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.2000.80.2.555","volume":"80","author":"Bezanilla F.","year":"2000","journal-title":"Physiol. Rev."},{"key":"bi050235tb00049\/bi050235tb00049_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0006-3495(99)76929-8","volume":"77","author":"Sheets M. F.","year":"1999","journal-title":"Biophys. J."},{"key":"bi050235tb00050\/bi050235tb00050_1","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.116.3.461","volume":"116","author":"Horn R.","year":"2000","journal-title":"J. Gen. Physiol."},{"key":"bi050235tb00051\/bi050235tb00051_1","volume-title":"J. Gen. Physiol. 110, 403\u2212413.","author":"Kontis K. J.","year":"1997"},{"key":"bi050235tb00052\/bi050235tb00052_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1469-7793.1999.0687u.x","volume":"516","author":"Groome J. R.","year":"1999","journal-title":"J. Physiol."},{"key":"bi050235tb00053\/bi050235tb00053_1","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.200308971","volume":"123","author":"Chanda B.","year":"2004","journal-title":"J. Gen. Physiol."},{"key":"bi050235tb00054\/bi050235tb00054_1","first-page":"45","volume-title":"14th World Congress on Animal, Plant, and Microbial Toxins, Abstract 16101","author":"Maslennikov I. V.","year":"2003"},{"key":"bi050235tb00055\/bi050235tb00055_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M307531200","volume":"279","author":"Cohen L.","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi050235t","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T02:24:21Z","timestamp":1706322261000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi050235t"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,1]]},"references-count":55,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2005,6,1]]}},"alternative-id":["10.1021\/bi050235t"],"URL":"https:\/\/doi.org\/10.1021\/bi050235t","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,1]]}}}