{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:12:07Z","timestamp":1790842327111,"version":"4.1.0"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1021\/bi050302j","type":"journal-article","created":{"date-parts":[[2005,6,14]],"date-time":"2005-06-14T00:32:39Z","timestamp":1118709159000},"page":"8578-8589","source":"Crossref","is-referenced-by-count":31,"title":["Inhibitors of Metallo-\u03b2-lactamase Generated from \u03b2-Lactam Antibiotics"],"prefix":"10.1021","volume":"44","author":[{"given":"Adriana","family":"Badarau","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., and Biological NMR Centre, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Llin\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., and Biological NMR Centre, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Laws","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., and Biological NMR Centre, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Damblon","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., and Biological NMR Centre, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, U.K., and Biological NMR Centre, Medical Sciences Building, University of Leicester, Leicester LE1 9HN, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2005,5,27]]},"reference":[{"key":"bi050302jb00001\/bi050302jb00001_1","volume-title":"Mol. Microbiol. 16, 385\u2212395.","author":"Fr\u00e8re J. M.","year":"1995"},{"key":"bi050302jb00002\/bi050302jb00002_1","volume-title":"Curr. Opin. Chem. Biol. 3, 614\u2212622.","author":"Wang Z.","year":"1999"},{"key":"bi050302jb00003\/bi050302jb00003_1","volume-title":"Antimicrob. Agents Chemother. 43, 902\u2212906","author":"Laraki N.","year":"1999"},{"key":"bi050302jb00004\/bi050302jb00004_1","volume-title":"Antimicrob. Agents Chemother. 45, 660\u2212663.","author":"Galleni M.","year":"2001"},{"key":"bi050302jb00005\/bi050302jb00005_1","volume-title":"Biochemistry 37, 12404\u221212411.","author":"Fabiane S. M.","year":"1998"},{"key":"bi050302jb00006\/bi050302jb00006_1","volume-title":"Biochemistry 37, 10173\u221210180","author":"Orellano E. G.","year":"1998"},{"key":"bi050302jb00007\/bi050302jb00007_1","volume-title":"Structure 4, 823\u2212836.","author":"Concha N. O.","year":"1996"},{"key":"bi050302jb00008\/bi050302jb00008_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0014-5793(98)01289-7","volume":"438","author":"Paul-Soto R.","year":"1998","journal-title":"FEBS Lett."},{"key":"bi050302jb00009\/bi050302jb00009_1","volume-title":"Biochemistry 38, 10013\u221210023.","author":"Wang Z.","year":"1999"},{"key":"bi050302jb00010\/bi050302jb00010_1","volume-title":"Antimicrob. Agents Chemother. 43, 902\u2212906","author":"Laraki N.","year":"1999"},{"key":"bi050302jb00011\/bi050302jb00011_1","volume-title":"Biochemistry 39, 4288\u22124298.","author":"Concha N. O.","year":"2000"},{"key":"bi050302jb00012\/bi050302jb00012_1","volume-title":"Biochemistry 36, 11534\u221211541.","author":"Hernandez Valladares M.","year":"1997"},{"key":"bi050302jb00013\/bi050302jb00013_1","volume-title":"Antimicrob. Agents Chemother. 42, 921\u2212926.","author":"Crowder M. W.","year":"1998"},{"key":"bi050302jb00014\/bi050302jb00014_1","volume-title":"Antimicrob. Agents Chemother. 45, 1254\u22121262.","author":"Mercuri P. S.","year":"2001"},{"key":"bi050302jb00015\/bi050302jb00015_1","volume-title":"Acta Crystallogr., Sect. D:\u2009 Biol. Crystallogr. 54, 313\u2212323.","author":"Carfi A.","year":"1998"},{"key":"bi050302jb00016\/bi050302jb00016_1","first-page":"57","volume":"54","author":"Carfi A.","year":"1998","journal-title":"Biol. Crystallogr."},{"key":"bi050302jb00017\/bi050302jb00017_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1998.2148","volume":"284","author":"Ullah J. H.","year":"1998","journal-title":"J. Mol. Biol."},{"key":"bi050302jb00018\/bi050302jb00018_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-2836(02)01271-8","volume":"325","author":"Garc\u00eda-S\u00e1ez P.","year":"2003","journal-title":"J. Mol. Biol."},{"key":"bi050302jb00019\/bi050302jb00019_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2004.10.070","volume":"345","author":"Garau G.","year":"2005","journal-title":"J. Mol. Biol."},{"key":"bi050302jb00020\/bi050302jb00020_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M301062200","volume":"278","author":"Garcia-Saez I.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"bi050302jb00021\/bi050302jb00021_1","volume-title":"Biochemistry 37, 6791\u22126800","author":"Fitzgerald P. M.","year":"1998"},{"key":"bi050302jb00022\/bi050302jb00022_1","doi-asserted-by":"crossref","DOI":"10.1002\/j.1460-2075.1995.tb00174.x","volume":"14","author":"Carfi A.","year":"1995","journal-title":"EMBO J."},{"key":"bi050302jb00023\/bi050302jb00023_1","volume-title":"Biochemistry 38, 16500\u221216506.","author":"Paul-Soto R.","year":"1999"},{"key":"bi050302jb00024\/bi050302jb00024_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M104742200","volume":"276","author":"Toney J. H.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"bi050302jb00025\/bi050302jb00025_1","volume-title":"Cell. Mol. Life Sci. 58, 2136\u22122143.","author":"Prosperi-Meys C.","year":"2001"},{"key":"bi050302jb00026\/bi050302jb00026_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja0112240","volume":"123","author":"Hemmingsen L.","year":"2001","journal-title":"J. Am. Chem. Soc."},{"key":"bi050302jb00027\/bi050302jb00027_1","doi-asserted-by":"crossref","DOI":"10.1016\/0960-894X(96)00453-2","volume":"6","author":"Walter M. W.","year":"1996","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"bi050302jb00028\/bi050302jb00028_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1006\/bioo.1998.1111","volume":"27","author":"Walter M. W.","year":"1999","journal-title":"Bioorg. Chem."},{"key":"bi050302jb00029\/bi050302jb00029_1","first-page":"43","volume":"38","author":"Arawaka Y.","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"bi050302jb00030\/bi050302jb00030_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj3310703","volume":"331","author":"Bounaga S.","year":"1998","journal-title":"Biochem J."},{"key":"bi050302jb00031\/bi050302jb00031_1","volume-title":"Biol. Pharm. Bull. 20, 1136\u22121140.","author":"Goto M.","year":"1997"},{"key":"bi050302jb00032\/bi050302jb00032_1","volume":"9","author":"Greenlee M. L.","year":"1999","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"bi050302jb00033\/bi050302jb00033_1","volume-title":"Biol. Chem. 276, 45015\u221245023.","author":"Mollard C.","year":"2001"},{"key":"bi050302jb00034\/bi050302jb00034_1","doi-asserted-by":"crossref","unstructured":"Bounaga, S., Galleni, M., Laws, A. P., and Page, M. I (2001) Cysteinyl peptide inhibitors of\n                      Bacillus cereus\n                      zinc beta-lactamase,\n                      Bioorg. Med. Chem.\n                      9\n                      , 503\u2212510.","DOI":"10.1016\/S0968-0896(00)00257-1"},{"key":"bi050302jb00035\/bi050302jb00035_1","volume":"179","author":"Hammond G. G.","year":"1999","journal-title":"FEMS Microbiol. Lett."},{"key":"bi050302jb00036\/bi050302jb00036_1","volume-title":"Antimicrob. Agents Chemother. 41, 135\u2212140","author":"Payne D. J.","year":"1997"},{"key":"bi050302jb00037\/bi050302jb00037_1","volume-title":"Chem. Biol. 5, 185\u2212196","author":"Toney J. H.","year":"1998"},{"key":"bi050302jb00038\/bi050302jb00038_1","volume-title":"Antimicrob. Agents Chemother. 46","author":"Payne D. J.","year":"2002"},{"key":"bi050302jb00039\/bi050302jb00039_1","volume-title":"Antimicrob. Agents Chemother. 46, 2450\u22122457.","author":"Siemann S.","year":"2002"},{"key":"bi050302jb00040\/bi050302jb00040_1","volume":"273","author":"Wang Z.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi050302jb00041\/bi050302jb00041_1","author":"Davies A., M.","year":"1985","journal-title":"J. Chem. Soc., Chem. Commun., 1702\u22121704."},{"key":"bi050302jb00042\/bi050302jb00042_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja00277a044","volume":"108","author":"Pratt R. F.","year":"1986","journal-title":"J. Am. Chem. Soc."},{"key":"bi050302jb00043\/bi050302jb00043_1","doi-asserted-by":"crossref","unstructured":"Morrison, J. F., and Walsh, C., T. (1988) The behavior and significance of slow-binding enzyme inhibitors,\n                      Adv. Enzymol. Relat. Areas Mol. Biol.\n                      61\n                      , 201\u2212301.","DOI":"10.1002\/9780470123072.ch5"},{"key":"bi050302jb00044\/bi050302jb00044_1","volume-title":"Arch. Biochem. Biophys. 82, 70\u221277","author":"Ellman G. L.","year":"1959"},{"key":"bi050302jb00045\/bi050302jb00045_1","first-page":"43","volume":"4","author":"Bundgaard H.","year":"1976","journal-title":"Arch. Pharm. Chemi, Sci. Ed."},{"key":"bi050302jb00046\/bi050302jb00046_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm00217a022","volume":"20","author":"Dinner A.","year":"1977","journal-title":"J. Med. Chem."},{"key":"bi050302jb00047\/bi050302jb00047_1","volume":"76","author":"Vilanova B.","year":"1993","journal-title":"Helv. Chim. Acta"},{"key":"bi050302jb00048\/bi050302jb00048_1","volume-title":"Adv. Phys. Org. Chem. 23, 165\u2212270.","author":"Page M. I.","year":"1987"},{"key":"bi050302jb00049\/bi050302jb00049_1","volume-title":"Protein Sci. 2, 543\u2212558.","author":"Pelton J. G.","year":"1993"},{"key":"bi050302jb00050\/bi050302jb00050_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M301562200","volume":"278","author":"Damblon C.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"bi050302jb00051\/bi050302jb00051_1","volume-title":"Biochemistry 42, 1673\u22121683.","author":"Siemann S.","year":"2003"},{"key":"bi050302jb00052\/bi050302jb00052_1","doi-asserted-by":"crossref","DOI":"10.1002\/jps.2600730135","volume":"73","author":"Ghebre-Sellassie I.","year":"1984","journal-title":"J. Pharm. Sci."},{"key":"bi050302jn00001\/bi050302jn00001_1","volume-title":"metallo-\u03b2-lactamases","author":"Abbreviations MBL"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi050302j","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T12:57:49Z","timestamp":1637240269000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi050302j"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,27]]},"references-count":53,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2005,6,1]]}},"alternative-id":["10.1021\/bi050302j"],"URL":"https:\/\/doi.org\/10.1021\/bi050302j","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,27]]}}}