{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T06:56:33Z","timestamp":1768719393486,"version":"3.49.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"35","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2005,9,1]]},"DOI":"10.1021\/bi0510072","type":"journal-article","created":{"date-parts":[[2005,8,30]],"date-time":"2005-08-30T04:17:21Z","timestamp":1125375441000},"page":"11758-11765","source":"Crossref","is-referenced-by-count":52,"title":["Structural Analysis of Botulinum Neurotoxin Serotype F Light Chain:\u2009 Implications on Substrate Binding and Inhibitor Design"],"prefix":"10.1021","volume":"44","author":[{"given":"Rakhi","family":"Agarwal","sequence":"first","affiliation":[{"name":"Biology Department, Brookhaven National Laboratory, Upton, New York 11973, and Department of Biochemistry, Medizinische Hochschule Hannover, 30623 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Binz","sequence":"additional","affiliation":[{"name":"Biology Department, Brookhaven National Laboratory, Upton, New York 11973, and Department of Biochemistry, Medizinische Hochschule Hannover, 30623 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramanyam","family":"Swaminathan","sequence":"additional","affiliation":[{"name":"Biology Department, Brookhaven National Laboratory, Upton, New York 11973, and Department of Biochemistry, Medizinische Hochschule Hannover, 30623 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2005,8,10]]},"reference":[{"key":"bi0510072b00001\/bi0510072b00001_1","volume-title":"Semin. Cell Biol. 5, 221\u2212229.","author":"Schiavo G.","year":"1994"},{"key":"bi0510072b00002\/bi0510072b00002_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0014-5793(94)00449-8","volume":"346","author":"Montecucco C.","year":"1994","journal-title":"FEBS Lett."},{"key":"bi0510072b00003\/bi0510072b00003_1","volume":"40","author":"Harvey S. M.","year":"2002","journal-title":"J. Clin. Micrbiol."},{"key":"bi0510072b00004\/bi0510072b00004_1","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.29.11.2618-2620.1991","volume":"29","author":"McCroskey L. M.","year":"1991","journal-title":"J. Clin. Microbiol."},{"key":"bi0510072b00005\/bi0510072b00005_1","volume":"14","author":"Paisley J. W.","year":"1995","journal-title":"Pediatr. Infect. Dis. J."},{"key":"bi0510072b00006\/bi0510072b00006_1","volume-title":"Biochimie 82, 427\u2212446.","author":"Humeau Y.","year":"2000"},{"key":"bi0510072b00007\/bi0510072b00007_1","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.2000.80.2.717","volume":"80","author":"Schiavo G.","year":"2000","journal-title":"Physiol. Rev."},{"key":"bi0510072b00008\/bi0510072b00008_1","volume-title":"Curr. Opin. Neurobiol. 4, 324\u2212329.","author":"Bennett M. K.","year":"1994"},{"key":"bi0510072b00009\/bi0510072b00009_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.132.1.167","volume":"132","author":"Rossetto O.","year":"1996","journal-title":"J. Cell Biol."},{"key":"bi0510072b00010\/bi0510072b00010_1","volume-title":"Nature 372, 415\u2212416.","author":"Rossetto O.","year":"1994"},{"key":"bi0510072b00011\/bi0510072b00011_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.34.20353","volume":"271","author":"Pellizzari R.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"bi0510072b00012\/bi0510072b00012_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0014-5793(97)00482-1","volume":"409","author":"Pellizzari R.","year":"1997","journal-title":"FEBS Lett."},{"key":"bi0510072b00013\/bi0510072b00013_1","volume-title":"Nature 432, 925\u2212929.","author":"Breidenbach M. A.","year":"2004"},{"key":"bi0510072b00014\/bi0510072b00014_1","volume-title":"Nat. Struct. Biol. 7, 687\u2212692.","author":"Hanson M. A.","year":"2000"},{"key":"bi0510072b00015\/bi0510072b00015_1","volume-title":"Acc. Chem. Res. 21, 333\u2212340.","author":"Matthews B. W.","year":"1988"},{"key":"bi0510072b00016\/bi0510072b00016_1","volume-title":"Biochemistry 44, 8291\u22128302.","author":"Agarwal R.","year":"2005"},{"key":"bi0510072b00017\/bi0510072b00017_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.pep.2003.10.017","volume":"34","author":"Agarwal R.","year":"2004","journal-title":"Protein Expression Purif."},{"key":"bi0510072b00018\/bi0510072b00018_1","volume-title":"Acta Crystallogr. D57, 1451\u22121456.","author":"Vagin A. A.","year":"2001"},{"key":"bi0510072b00019\/bi0510072b00019_1","volume-title":"Methods Enzymol. 276, 307\u2212326.","author":"Otwinowski Z.","year":"1997"},{"key":"bi0510072b00020\/bi0510072b00020_1","volume-title":"Nat. Struct. Biol. 6, 458\u2212463.","author":"Perrakis A.","year":"1999"},{"key":"bi0510072b00021\/bi0510072b00021_1","volume":"47","author":"Jones T. A.","year":"1991","journal-title":"Acta Crystallogr."},{"key":"bi0510072b00022\/bi0510072b00022_1","volume-title":"Acta Crystallogr. D54, 905\u2212921.","author":"Brunger A. T.","year":"1998"},{"key":"bi0510072b00023\/bi0510072b00023_1","volume-title":"Biochemistry 43, 6637\u22126644.","author":"Agarwal R.","year":"2004"},{"key":"bi0510072b00024\/bi0510072b00024_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 101","author":"Segelke B.","year":"2004"},{"key":"bi0510072b00025\/bi0510072b00025_1","volume":"20","author":"Ahmed S. A.","year":"2001","journal-title":"J. Protein Chem."},{"key":"bi0510072b00026\/bi0510072b00026_1","volume-title":"Toxicon 45, 929\u2212939.","author":"Rao K. N.","year":"2005"},{"key":"bi0510072b00027\/bi0510072b00027_1","volume-title":"Biochemistry 41, 1717\u22121723.","author":"Binz T.","year":"2002"},{"key":"bi0510072b00028\/bi0510072b00028_1","volume-title":"Toxicon 39, 115\u22121159.","author":"Rossetto O.","year":"2001"},{"key":"bi0510072b00029\/bi0510072b00029_1","volume-title":"Biochem. Biophys. Res. Commun. 288, 1231\u22121237.","author":"Rigoni M.","year":"2001"},{"key":"bi0510072b00030\/bi0510072b00030_1","volume-title":"Biochemistry 39, 2399\u22122405.","author":"Li L.","year":"2000"},{"key":"bi0510072b00031\/bi0510072b00031_1","volume-title":"Movement Disord. 19 (Suppl. 8), S17\u2212S22.","author":"Swaminathan S.","year":"2004"},{"key":"bi0510072b00032\/bi0510072b00032_1","volume-title":"Biochemistry 44, 4067\u22124073.","author":"Schmidt J. J.","year":"2005"},{"key":"bi0510072b00033\/bi0510072b00033_1","volume":"291","author":"Lacy D. B.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"bi0510072b00034\/bi0510072b00034_1","doi-asserted-by":"crossref","first-page":"5556","DOI":"10.1093\/nar\/18.18.5556","volume":"18","author":"Binz T.","year":"1990","journal-title":"Nucleic Acids Res."},{"key":"bi0510072b00035\/bi0510072b00035_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1432-1033.1994.00263.x","volume":"225","author":"Shone V. C.","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"bi0510072b00036\/bi0510072b00036_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1023\/A:1026386710428","volume":"16","author":"Schmidt J. J.","year":"1997","journal-title":"J. Protein Chem."},{"key":"bi0510072b00037\/bi0510072b00037_1","doi-asserted-by":"crossref","DOI":"10.1046\/j.1471-4159.1999.0720327.x","volume":"72","author":"Vaidyanathan V. V.","year":"1999","journal-title":"J. Neurochem."},{"key":"bi0510072b00038\/bi0510072b00038_1","doi-asserted-by":"crossref","DOI":"10.1124\/jpet.103.058149","volume":"308","author":"Simpson L. L.","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"bi0510072b00039\/bi0510072b00039_1","doi-asserted-by":"crossref","DOI":"10.1023\/A:1026549431380","volume":"19","author":"Ahmed S. A.","year":"2000","journal-title":"J. Protein Chem."},{"key":"bi0510072b00040\/bi0510072b00040_1","volume-title":"Sb. Lek. 104, 157\u2212170.","author":"Fuchs O.","year":"2003"},{"key":"bi0510072b00041\/bi0510072b00041_1","doi-asserted-by":"crossref","DOI":"10.1107\/S0021889891004399","volume":"24","author":"Kraulis P. J.","year":"1991","journal-title":"J. Appl. Crystallogr."},{"key":"bi0510072b00042\/bi0510072b00042_1","volume-title":"in The PyMOL User's Manual","author":"DeLano W. L.","year":"2002"},{"key":"bi0510072n00001\/bi0510072n00001_1","volume-title":"botulinum neurotoxin","author":"Abbreviations NT"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi0510072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T01:31:30Z","timestamp":1678152690000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi0510072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,10]]},"references-count":43,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2005,9,1]]}},"alternative-id":["10.1021\/bi0510072"],"URL":"https:\/\/doi.org\/10.1021\/bi0510072","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,10]]}}}