{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:34:44Z","timestamp":1791084884437,"version":"4.1.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2006,6,1]]},"DOI":"10.1021\/bi060365h","type":"journal-article","created":{"date-parts":[[2006,6,10]],"date-time":"2006-06-10T17:20:26Z","timestamp":1149960026000},"page":"7750-7762","source":"Crossref","is-referenced-by-count":31,"title":["Influencing Cellular Transformation by Modulating the Rates of GTP Hydrolysis by Cdc42"],"prefix":"10.1021","volume":"45","author":[{"given":"Nancy","family":"Fidyk","sequence":"first","affiliation":[{"name":"Departments of Molecular Medicine and Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Molecular Medicine and Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Cerione","sequence":"additional","affiliation":[{"name":"Departments of Molecular Medicine and Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,6,3]]},"reference":[{"key":"bi060365hb00001\/bi060365hb00001_1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.bi.56.070187.004023","volume":"56","author":"Barbacid M.","year":"1987","journal-title":"Rev. Biochem."},{"key":"bi060365hb00002\/bi060365hb00002_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0955-0674(97)80156-1","volume":"9","author":"Tapon N.","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"bi060365hb00003\/bi060365hb00003_1","volume-title":"Genes Dev. 11, 2295\u22122322.","author":"Van Aelst L.","year":"1997"},{"key":"bi060365hb00004\/bi060365hb00004_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/MMBR.63.1.54-105.1999","volume":"63","author":"Johnson D. I.","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"bi060365hb00005\/bi060365hb00005_1","volume":"276","author":"Tu S.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00006\/bi060365hb00006_1","volume":"270","author":"Bagrodia S.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00007\/bi060365hb00007_1","volume-title":"Cell 81, 1137\u22121146.","author":"Coso O. A.","year":"1995"},{"key":"bi060365hb00008\/bi060365hb00008_1","volume-title":"Cell 81, 1147\u22121157.","author":"Minden A.","year":"1995"},{"key":"bi060365hb00009\/bi060365hb00009_1","volume-title":"Science 269, 1270\u22121272.","author":"Olson M. F.","year":"1995"},{"key":"bi060365hb00010\/bi060365hb00010_1","volume":"270","author":"Zhang S.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00011\/bi060365hb00011_1","volume":"276","author":"Yang W.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00012\/bi060365hb00012_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/8977","volume":"1","author":"Kroschewski R.","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"bi060365hb00013\/bi060365hb00013_1","doi-asserted-by":"crossref","DOI":"10.1093\/emboj\/20.9.2171","volume":"20","author":"Musch A.","year":"2001","journal-title":"EMBO J."},{"key":"bi060365hb00014\/bi060365hb00014_1","volume-title":"Mol. Biol. Cell 13, 621\u2212631.","author":"Fucini R. V.","year":"2002"},{"key":"bi060365hb00015\/bi060365hb00015_1","volume-title":"Mol. Biol. Cell 13, 866\u2212879.","author":"Luna A.","year":"2002"},{"key":"bi060365hb00016\/bi060365hb00016_1","volume-title":"Nature 405, 800\u2212804.","author":"Wu W. J.","year":"2000"},{"key":"bi060365hb00017\/bi060365hb00017_1","volume-title":"Trends Cell Biol. 14, 127\u2212132.","author":"Cerione R. A.","year":"2004"},{"key":"bi060365hb00018\/bi060365hb00018_1","first-page":"23","volume":"1332","author":"Whitehead I. P.","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"bi060365hb00019\/bi060365hb00019_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0014-5793(01)03310-5","volume":"513","author":"Hoffman G. R.","year":"2002","journal-title":"FEBS Lett."},{"key":"bi060365hb00020\/bi060365hb00020_1","volume-title":"Biochemistry 43, 837\u2212842.","author":"Erickson J. W.","year":"2004"},{"key":"bi060365hb00021\/bi060365hb00021_1","unstructured":"Fukumoto, Y., Kaibuchi, K., Hori, Y., Fujioka, H., Araki, S., Ueda, T., Kikuchi, A., and Takai, Y. (1990) Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins,Oncogene5, 1321\u22121328."},{"key":"bi060365hb00022\/bi060365hb00022_1","first-page":"22","volume":"13","author":"Moon S. Y.","year":"2003","journal-title":"Trends Cell Biol."},{"key":"bi060365hb00023\/bi060365hb00023_1","volume-title":"Curr. Biol. 7, 794\u2212797.","author":"Lin R.","year":"1997"},{"key":"bi060365hb00024\/bi060365hb00024_1","volume":"274","author":"Lin R.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00025\/bi060365hb00025_1","volume-title":"Biochemistry 41, 12350\u221212358.","author":"Tu S. S.","year":"2002"},{"key":"bi060365hb00026\/bi060365hb00026_1","volume-title":"Nat. Struct. Biol. 5, 1047\u22121052.","author":"Nassar N.","year":"1998"},{"key":"bi060365hb00027\/bi060365hb00027_1","volume-title":"Biochemistry 41, 15644\u221215653.","author":"Fidyk N. J.","year":"2002"},{"key":"bi060365hb00028\/bi060365hb00028_1","doi-asserted-by":"crossref","DOI":"10.1016\/0167-4838(83)90267-4","volume":"742","author":"Hiratsuka T.","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"bi060365hb00029\/bi060365hb00029_1","volume-title":"Biochemistry 33, 12323\u221212328.","author":"Leonard D. A.","year":"1994"},{"key":"bi060365hb00030\/bi060365hb00030_1","volume":"280","author":"Wang J. B.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00031\/bi060365hb00031_1","volume-title":"Nat. Cell Biol. 3, 927\u2212932.","author":"Hussain N. K.","year":"2001"},{"key":"bi060365hb00032\/bi060365hb00032_1","doi-asserted-by":"crossref","DOI":"10.1021\/bi00110a023","volume-title":"Is there a rate-limiting step before GTP cleavage by H-ras","author":"Rensland H.","year":"1991"},{"key":"bi060365hb00033\/bi060365hb00033_1","doi-asserted-by":"crossref","unstructured":"Moore, K. J., Webb, M. R., and Eccleston, J. F. (1993) Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP:\u2009 Studies with a fluorescent GTP analogue,Biochemistry32, 7451\u22127459.","DOI":"10.1021\/bi00080a016"},{"key":"bi060365hb00034\/bi060365hb00034_1","volume":"270","author":"Burbelo P. D.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00035\/bi060365hb00035_1","volume":"272","author":"Yang W.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00036\/bi060365hb00036_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.37.23633","volume":"273","author":"Bagrodia S.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00037\/bi060365hb00037_1","volume-title":"Mol. Cell. Biol. 15","author":"Kozma R.","year":"1995"},{"key":"bi060365hb00038\/bi060365hb00038_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0092-8674(95)90370-4","volume":"81","author":"Nobes C. D.","year":"1995","journal-title":"Cell"},{"key":"bi060365hb00039\/bi060365hb00039_1","volume":"273","author":"Leonard D. A.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00040\/bi060365hb00040_1","volume-title":"Cell 114, 715\u2212725.","author":"Wu W. J.","year":"2003"},{"key":"bi060365hb00041\/bi060365hb00041_1","first-page":"65","volume":"269","author":"Hart M. J.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00042\/bi060365hb00042_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(19)74277-X","volume":"268","author":"Barfod E. T.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00043\/bi060365hb00043_1","volume":"278","author":"Ching Y. P.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"bi060365hb00044\/bi060365hb00044_1","volume-title":"Rac1, and Cdc42 GTPases is associated with progression in testicular cancer, Clin. Cancer Res. 10, 4799\u22124805.","author":"Kamai T.","year":"2004"},{"key":"bi060365hb00045\/bi060365hb00045_1","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bjc.6600510","volume":"87","author":"Fritz G.","year":"2002","journal-title":"Br. J. Cancer"},{"key":"bi060365hb00046\/bi060365hb00046_1","volume-title":"Oncogene 21, 2901\u22122907.","author":"Meriane M.","year":"2002"},{"key":"bi060365hn00001\/bi060365hn00001_1","volume-title":"guanosine 5\u2018-3\u2018-O-triphosphate (GTP) binding protein","author":"Abbreviations"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi060365h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T05:37:34Z","timestamp":1633930654000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi060365h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,1]]},"references-count":47,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2006,6,1]]}},"alternative-id":["10.1021\/bi060365h"],"URL":"https:\/\/doi.org\/10.1021\/bi060365h","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,1]]}}}