{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:03:02Z","timestamp":1792461782545,"version":"4.5.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"31","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2006,8,1]]},"DOI":"10.1021\/bi060579z","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T05:00:25Z","timestamp":1153112425000},"page":"9496-9508","source":"Crossref","is-referenced-by-count":300,"title":["Conserved and Cooperative Assembly of Membrane-Bound \u03b1-Helical States of Islet Amyloid Polypeptide"],"prefix":"10.1021","volume":"45","author":[{"given":"Jefferson D.","family":"Knight","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520-8114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Hebda","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520-8114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Miranker","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520-8114"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,7,15]]},"reference":[{"key":"bi060579zb00001\/bi060579zb00001_1","volume-title":"Diabetologia 32, 271\u2212281.","author":"Hutton J. C.","year":"1989"},{"key":"bi060579zb00002\/bi060579zb00002_1","volume":"89","author":"Hull R. L.","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"bi060579zb00003\/bi060579zb00003_1","first-page":"8","volume":"130","author":"Johnson K. H.","year":"1988","journal-title":"Am. J. Pathol."},{"key":"bi060579zb00004\/bi060579zb00004_1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.neuro.26.010302.081142","volume":"26","author":"Caughey B.","year":"2003","journal-title":"Rev. Neurosci."},{"key":"bi060579zb00005\/bi060579zb00005_1","volume-title":"Nature 435, 773\u2212778.","author":"Nelson R.","year":"2005"},{"key":"bi060579zb00006\/bi060579zb00006_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.sbi.2003.12.002","volume":"14","author":"Tycko R.","year":"2004","journal-title":"Curr. Opin. Struct. Biol."},{"key":"bi060579zb00007\/bi060579zb00007_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M406853200","volume":"279","author":"Jayasinghe S. A.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"bi060579zb00008\/bi060579zb00008_1","volume-title":"Biochemistry 39, 3491\u22123499.","author":"Benzinger T. L.","year":"2000"},{"key":"bi060579zb00009\/bi060579zb00009_1","volume-title":"Diabetes 48, 491\u2212498.","author":"Janson J.","year":"1999"},{"key":"bi060579zb00010\/bi060579zb00010_1","volume-title":"Nature 440, 352\u2212357.","author":"Lesne S.","year":"2006"},{"key":"bi060579zb00011\/bi060579zb00011_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.C400260200","volume":"279","author":"Kayed R.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"bi060579zb00012\/bi060579zb00012_1","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.200207113","volume":"160","author":"Ehehalt R.","year":"2003","journal-title":"J. Cell Biol."},{"key":"bi060579zb00013\/bi060579zb00013_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 93","author":"Vey M.","year":"1996"},{"key":"bi060579zb00014\/bi060579zb00014_1","volume-title":"Cell 123, 383\u2212396.","author":"Chandra S.","year":"2005"},{"key":"bi060579zb00015\/bi060579zb00015_1","volume-title":"Diabetes 48, 241\u2212253.","author":"Kahn S. E.","year":"1999"},{"key":"bi060579zb00016\/bi060579zb00016_1","volume-title":"Exp. Clin. Endocrinol. Diabetes 109, 307\u2212319.","author":"Tschop M.","year":"2001"},{"key":"bi060579zb00017\/bi060579zb00017_1","volume-title":"Diabetologia 42, 427\u2212434.","author":"Hoppener J. W.","year":"1999"},{"key":"bi060579zb00018\/bi060579zb00018_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 95","author":"Shimabukuro M.","year":"1998"},{"key":"bi060579zb00019\/bi060579zb00019_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.50.33501","volume":"273","author":"Efanova I. B.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi060579zb00020\/bi060579zb00020_1","volume-title":"Endocrinology 143, 339\u2212342.","author":"Poitout V.","year":"2002"},{"key":"bi060579zb00021\/bi060579zb00021_1","volume-title":"Diabetes 53, 1509\u22121516.","author":"Butler A. E.","year":"2004"},{"key":"bi060579zb00022\/bi060579zb00022_1","volume-title":"Diabetes 52, 2304\u22122314.","author":"Butler A. E.","year":"2003"},{"key":"bi060579zb00023\/bi060579zb00023_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2004.06.086","volume":"341","author":"Knight J. D.","year":"2004","journal-title":"J. Mol. Biol."},{"key":"bi060579zb00024\/bi060579zb00024_1","volume-title":"Lipids 29, 685\u2212692.","author":"Rustenbeck I.","year":"1994"},{"key":"bi060579zb00025\/bi060579zb00025_1","volume-title":"Endocrinology 118, 1498\u22121503.","author":"Farese R. V.","year":"1986"},{"key":"bi060579zb00026\/bi060579zb00026_1","volume-title":"Biochemistry 44, 12113\u221212119.","author":"Jayasinghe S. A.","year":"2005"},{"key":"bi060579zb00027\/bi060579zb00027_1","volume-title":"Biochemistry 36, 14845\u221214852.","author":"Terzi E.","year":"1997"},{"key":"bi060579zb00028\/bi060579zb00028_1","volume":"275","author":"Jo E.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"bi060579zb00029\/bi060579zb00029_1","volume-title":"Biochemistry 41, 4694\u22124703.","author":"Padrick S. B.","year":"2002"},{"key":"bi060579zb00030\/bi060579zb00030_1","volume-title":"Biochemistry 42, 2720\u22122730.","author":"Munishkina L. A.","year":"2003"},{"key":"bi060579zb00031\/bi060579zb00031_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M204168200","volume":"277","author":"Fezoui Y.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"bi060579zb00032\/bi060579zb00032_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.2001.4970","volume":"312","author":"Kirkitadze M. D.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"bi060579zb00033\/bi060579zb00033_1","volume-title":"Methods Enzymol. 383, 282\u2212317.","author":"Greenfield N. J.","year":"2004"},{"key":"bi060579zb00034\/bi060579zb00034_1","volume-title":"SELCON, and CDSSTR methods with an expanded reference set, Anal. Biochem. 287, 252\u2212260.","author":"Sreerama N.","year":"2000"},{"key":"bi060579zb00035\/bi060579zb00035_1","volume-title":"Protein Sci. 13, 100\u2212112.","author":"Sreerama N.","year":"2004"},{"key":"bi060579zb00036\/bi060579zb00036_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1995.0525","volume":"252","author":"Terzi E.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"bi060579zb00037\/bi060579zb00037_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1998.1640","volume":"277","author":"Wimley W. C.","year":"1998","journal-title":"J. Mol. Biol."},{"key":"bi060579zb00038\/bi060579zb00038_1","volume-title":"Anal. Biochem. 166, 368\u2212379.","author":"Schagger H.","year":"1987"},{"key":"bi060579zb00039\/bi060579zb00039_1","volume-title":"Methods Mol. Biol. 307, 289\u2212313.","author":"Wensel T. G.","year":"2005"},{"key":"bi060579zb00040\/bi060579zb00040_1","volume":"342","author":"Green J. D.","year":"2004","journal-title":"J. Mol. Biol."},{"key":"bi060579zb00041\/bi060579zb00041_1","volume-title":"Biochemistry 44, 15823\u221215833.","author":"Tamba Y.","year":"2005"},{"key":"bi060579zb00042\/bi060579zb00042_1","volume-title":"Peptides 25, 1633\u22121642.","author":"Chang C. L.","year":"2004"},{"key":"bi060579zb00043\/bi060579zb00043_1","volume-title":"Bioinformatics 14, 380\u2212381.","author":"Brown N. P.","year":"1998"},{"key":"bi060579zb00044\/bi060579zb00044_1","volume-title":"http:\/\/blanco.biomol.uci.edu\/mpex","author":"Jayasinghe S. A.","year":"2000"},{"key":"bi060579zb00045\/bi060579zb00045_1","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.biophys.28.1.319","volume":"28","author":"White S. H.","year":"1999","journal-title":"Rev. Biophys. Biomol. Struct."},{"key":"bi060579zb00046\/bi060579zb00046_1","volume-title":"Peptides 25, 217\u2212232.","author":"Kurganov B.","year":"2004"},{"key":"bi060579zb00047\/bi060579zb00047_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0003-9861(68)90554-7","volume":"126","author":"Habeeb A. J.","year":"1968","journal-title":"Arch. Biochem. Biophys."},{"key":"bi060579zb00048\/bi060579zb00048_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.2001.4608","volume":"308","author":"Padrick S. B.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"bi060579zb00049\/bi060579zb00049_1","volume-title":"Methods Enzymol. 309, 256\u2212274.","author":"Ferrone F.","year":"1999"},{"key":"bi060579zb00050\/bi060579zb00050_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.4.1988","volume":"271","author":"Mirzabekov T. A.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"bi060579zb00051\/bi060579zb00051_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.febslet.2004.09.075","volume":"577","author":"Sparr E.","year":"2004","journal-title":"FEBS Lett."},{"key":"bi060579zb00052\/bi060579zb00052_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.2001.4593","volume":"308","author":"Jaikaran E. T.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"bi060579zb00053\/bi060579zb00053_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 87","author":"Westermark P.","year":"1990"},{"key":"bi060579zb00054\/bi060579zb00054_1","volume-title":"Biochemistry 13, 222\u2212245.","author":"Chou P. Y.","year":"1974"},{"key":"bi060579zb00055\/bi060579zb00055_1","doi-asserted-by":"crossref","DOI":"10.1016\/0022-2836(84)90309-7","volume":"179","author":"Eisenberg D.","year":"1984","journal-title":"J. Mol. Biol."},{"key":"bi060579zb00056\/bi060579zb00056_1","volume-title":"Biochemistry 30, 575\u2212582.","author":"Breeze A. L.","year":"1991"},{"key":"bi060579zb00057\/bi060579zb00057_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/prot.340070102","volume":"7","author":"Cohen C.","year":"1990","journal-title":"Proteins"},{"key":"bi060579zb00058\/bi060579zb00058_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 97","author":"Antzutkin O. N.","year":"2000"},{"key":"bi060579zb00059\/bi060579zb00059_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0005-2736(01)00382-0","volume":"1514","author":"Ladokhin A. S.","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"bi060579zb00060\/bi060579zb00060_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 102","author":"Quist A.","year":"2005"},{"key":"bi060579zb00061\/bi060579zb00061_1","volume-title":"8, 375\u2212384.","author":"Lingohr M. K.","year":"2002"},{"key":"bi060579zb00062\/bi060579zb00062_1","volume-title":"Biochemistry 34, 3423\u22123429.","author":"Matsuzaki K.","year":"1995"},{"key":"bi060579zb00063\/bi060579zb00063_1","volume-title":"Biopolymers 64, 314\u2212327.","author":"Wakamatsu K.","year":"2002"},{"key":"bi060579zn00001\/bi060579zn00001_1","volume-title":"islet amyloid polypeptide (amylin)","author":"Abbreviations IAPP"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi060579z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T02:34:24Z","timestamp":1683513264000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi060579z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,15]]},"references-count":64,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2006,8,1]]}},"alternative-id":["10.1021\/bi060579z"],"URL":"https:\/\/doi.org\/10.1021\/bi060579z","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,15]]}}}