{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:54:35Z","timestamp":1791154475197,"version":"4.1.0"},"reference-count":36,"publisher":"American Chemical Society (ACS)","issue":"39","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2006,10,1]]},"DOI":"10.1021\/bi061180d","type":"journal-article","created":{"date-parts":[[2006,9,9]],"date-time":"2006-09-09T07:06:17Z","timestamp":1157785577000},"page":"11727-11736","source":"Crossref","is-referenced-by-count":269,"title":["Inhibitors and Inactivators of Protein Arginine Deiminase 4:\u2009 Functional and Structural Characterization\n                    <sup>,<\/sup>"],"prefix":"10.1021","volume":"45","author":[{"given":"Yuan","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Street, MCA 51A, Los Angeles, California 90089, and Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyouhei","family":"Arita","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Street, MCA 51A, Los Angeles, California 90089, and Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Street, MCA 51A, Los Angeles, California 90089, and Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Knuckley","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Street, MCA 51A, Los Angeles, California 90089, and Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Street, MCA 51A, Los Angeles, California 90089, and Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Stallcup","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Street, MCA 51A, Los Angeles, California 90089, and Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Street, MCA 51A, Los Angeles, California 90089, and Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Street, MCA 51A, Los Angeles, California 90089, and Graduate School of Integrated Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,9,9]]},"reference":[{"key":"bi061180db00001\/bi061180db00001_1","volume-title":"Nat. Genet. 34, 395\u2212402.","author":"Suzuki A.","year":"2003"},{"key":"bi061180db00002\/bi061180db00002_1","first-page":"6","volume":"54","author":"Kang C. P.","year":"2006","journal-title":"Arthritis Rheum."},{"key":"bi061180db00003\/bi061180db00003_1","volume-title":"Arthritis Res. Ther. 7, R458\u221267.","author":"Lundberg K.","year":"2005"},{"key":"bi061180db00004\/bi061180db00004_1","volume":"171","author":"Hill J. A.","year":"2003","journal-title":"J. Immunol."},{"key":"bi061180db00005\/bi061180db00005_1","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.162.1.585","volume":"162","author":"Girbal-Neuhauser E.","year":"1999","journal-title":"J. Immunol."},{"key":"bi061180db00006\/bi061180db00006_1","volume-title":"Clin. Exp. Immunol. 119, 544\u221252.","author":"Masson-Bessiere C.","year":"2000"},{"key":"bi061180db00007\/bi061180db00007_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI1316","volume":"101","author":"Schellekens G. A.","year":"1998","journal-title":"J. Clin. Invest."},{"key":"bi061180db00008\/bi061180db00008_1","volume-title":"Ann. Rheum. Dis. 60, 882\u22127.","author":"Nogueira L.","year":"2001"},{"key":"bi061180db00009\/bi061180db00009_1","volume-title":"Arthritis Rheum. 46, 1185\u221295.","author":"Union A.","year":"2002"},{"key":"bi061180db00010\/bi061180db00010_1","volume-title":"Arthritis Rheum. 46","author":"Vincent C.","year":"2002"},{"key":"bi061180db00011\/bi061180db00011_1","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.166.6.4177","volume":"166","author":"Masson-Bessiere C.","year":"2001","journal-title":"J. Immunol."},{"key":"bi061180db00012\/bi061180db00012_1","volume-title":"Arthritis Rheum. 43, 155\u221263.","author":"Schellekens G. A.","year":"2000"},{"key":"bi061180db00013\/bi061180db00013_1","volume-title":"Unlocking the \u201cPAD","author":"Utz P. J.","year":"2004"},{"key":"bi061180db00014\/bi061180db00014_1","volume-title":"Biochemistry 44, 10570\u221282.","author":"Kearney P. L.","year":"2005"},{"key":"bi061180db00015\/bi061180db00015_1","volume-title":"BioEssays 25, 1106\u221218.","author":"Vossenaar E. R.","year":"2003"},{"key":"bi061180db00016\/bi061180db00016_1","volume-title":"Biochemistry 44, 13744\u221252.","author":"Stone E. M.","year":"2005"},{"key":"bi061180db00017\/bi061180db00017_1","volume":"128","author":"Luo Y.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"bi061180db00018\/bi061180db00018_1","volume-title":"Biochem. Biophys. Res. Commun. 243, 641\u22126.","author":"Asaga H.","year":"1998"},{"key":"bi061180db00019\/bi061180db00019_1","volume":"274","author":"Nakashima K.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi061180db00020\/bi061180db00020_1","volume-title":"Cell 118, 545\u221253.","author":"Cuthbert G. L.","year":"2004"},{"key":"bi061180db00021\/bi061180db00021_1","volume-title":"Science 306, 279\u221283.","author":"Wang Y.","year":"2004"},{"key":"bi061180db00022\/bi061180db00022_1","volume-title":"Apoptosis 11, 183\u221296.","author":"Liu G. Y.","year":"2006"},{"key":"bi061180db00023\/bi061180db00023_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 102","author":"Lee Y. H.","year":"2005"},{"key":"bi061180db00024\/bi061180db00024_1","volume-title":"Biochemistry 44, 5827\u221234.","author":"Hagiwara T.","year":"2005"},{"key":"bi061180db00025\/bi061180db00025_1","volume-title":"Biochem. Biophys. Res. Commun. 290, 979\u221283.","author":"Hagiwara T.","year":"2002"},{"key":"bi061180db00026\/bi061180db00026_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0167-4838(98)00175-7","volume":"1388","author":"Pritzker L. B.","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"bi061180db00027\/bi061180db00027_1","doi-asserted-by":"crossref","DOI":"10.1021\/jm00173a024","volume":"33","author":"Hughes L. R.","year":"1990","journal-title":"J. Med. Chem."},{"key":"bi061180db00028\/bi061180db00028_1","volume-title":"Grafit, version 5.0.11","author":"Leatherbarrow R. J.","year":"2004"},{"key":"bi061180db00029\/bi061180db00029_1","volume-title":"Evaluation of enzyme inhibitors in drug discovery:\u2009 A guide for medicinal chemists and pharmacologists","volume":"46","author":"Copeland R.","year":"2005"},{"key":"bi061180db00030\/bi061180db00030_1","volume-title":"Nat. Struct. Mol. Biol. 11, 777\u221283.","author":"Arita K.","year":"2004"},{"key":"bi061180db00031\/bi061180db00031_1","volume-title":"Acta Crystallogr. D59, 2332\u22123.","author":"Arita K.","year":"2003"},{"key":"bi061180db00032\/bi061180db00032_1","volume-title":"Methods Enzymol. 276, 307\u221226.","author":"Otwinowski Z.","year":"1997"},{"key":"bi061180db00033\/bi061180db00033_1","volume-title":"Acta Crystallogr. D54 (Part 5), 905\u221221.","author":"Brunger A. T.","year":"1998"},{"key":"bi061180db00034\/bi061180db00034_1","volume":"47","author":"Jones T. A.","year":"1991","journal-title":"Acta Crystallogr."},{"key":"bi061180db00035\/bi061180db00035_1","volume-title":"Acta Crystallogr. D53, 240\u221255.","author":"Murshudov G. N.","year":"1997"},{"key":"bi061180dn00001\/bi061180dn00001_1","volume-title":"protein arginine deiminase","author":"Abbreviations PAD"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi061180d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T16:12:16Z","timestamp":1683562336000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi061180d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,9]]},"references-count":36,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2006,10,1]]}},"alternative-id":["10.1021\/bi061180d"],"URL":"https:\/\/doi.org\/10.1021\/bi061180d","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,9]]}}}