{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:34:22Z","timestamp":1778668462404,"version":"3.51.4"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"34","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2010,8,31]]},"DOI":"10.1021\/bi100887w","type":"journal-article","created":{"date-parts":[[2010,7,27]],"date-time":"2010-07-27T13:05:32Z","timestamp":1280235932000},"page":"7403-7410","source":"Crossref","is-referenced-by-count":6,"title":["Anthrax Toxin Receptor 1\/Tumor Endothelial Marker 8: Mutation of Conserved Inserted Domain Residues Overrides Cytosolic Control of Protective Antigen Binding"],"prefix":"10.1021","volume":"49","author":[{"given":"Jordan D.","family":"Ramey","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics"},{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie A.","family":"Villareal","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina C.","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Ping","family":"Xiong","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Clubb","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Bradley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Molecular Genetics"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2010,8,6]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev.biochem.75.103004.142728","volume":"76","author":"Young J. A.","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399406010714","volume":"8","author":"Banks D. J.","year":"2006","journal-title":"Expert Rev. Mol. Med."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.0431098100","volume":"100","author":"Scobie H. M.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","volume":"414","author":"Bradley K. A.","year":"2001","journal-title":"Nature"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"16396","DOI":"10.1016\/S0021-9258(18)42016-9","volume":"267","author":"Molloy S. S.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"10277","DOI":"10.1073\/pnas.89.21.10277","volume":"89","author":"Klimpel K. R.","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1128\/CVI.00064-08","volume":"15","author":"Goldman D. L.","year":"2008","journal-title":"Clin. Vaccine Immunol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.200211018","volume":"160","author":"Abrami L.","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.1113380","volume":"309","author":"Krantz B. A.","year":"2005","journal-title":"Science"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1083\/jcb.200507067","volume":"172","author":"Abrami L.","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"10432","DOI":"10.1021\/bi990792d","volume":"38","author":"Miller C. J.","year":"1999","journal-title":"Biochemistry"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"13278","DOI":"10.1073\/pnas.0505865102","volume":"102","author":"Rainey G. J.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1111\/j.1365-2958.1994.tb00500.x","volume":"13","author":"Klimpel K. R.","year":"1994","journal-title":"Mol. Microbiol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1073\/pnas.79.10.3162","volume":"79","author":"Leppla S. H.","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"49342","DOI":"10.1074\/jbc.M307900200","volume":"278","author":"Bradley K. A.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"13147","DOI":"10.1073\/pnas.0405405101","volume":"101","author":"Lacy D. B.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nature02763","volume":"430","author":"Santelli E.","year":"2004","journal-title":"Nature"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0092-8674(02)01257-6","volume":"112","author":"Shimaoka M.","year":"2003","journal-title":"Cell"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1371\/journal.pone.0000099","volume":"1","author":"Scobie H. M.","year":"2006","journal-title":"PLoS ONE"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"12531","DOI":"10.1074\/jbc.270.21.12531","volume":"270","author":"Kamata T.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.143.6.1523","volume":"143","author":"Li R.","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1146\/annurev.immunol.25.022106.141618","volume":"25","author":"Luo B. H.","year":"2007","journal-title":"Annu. Rev. Immunol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1073\/pnas.101130498","volume":"98","author":"Shimaoka M.","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"16737","DOI":"10.1073\/pnas.252633099","volume":"99","author":"Shimaoka M.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/77978","volume":"7","author":"Shimaoka M.","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/IAI.01073-08","volume":"77","author":"Go M. Y.","year":"2009","journal-title":"Infect. Immun."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1073\/pnas.0401506101","volume":"101","author":"Lacy D. B.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1074\/jbc.M210321200","volume":"278","author":"Liu S.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"10577","DOI":"10.1021\/bi9015296","volume":"48","author":"Garlick K. M.","year":"2009","journal-title":"Biochemistry"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"23227","DOI":"10.1074\/jbc.M603676200","volume":"281","author":"Werner E.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.pep.2006.04.011","volume":"49","author":"Ding Z.","year":"2006","journal-title":"Protein Expression Purif."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1128\/IAI.01329-08","volume":"77","author":"Maldonado-Arocho F. J.","year":"2009","journal-title":"Infect. Immun."},{"key":"ref33\/cit33","first-page":"9","volume":"32","author":"Kruger N. J.","year":"1994","journal-title":"Methods Mol. Biol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/abio.1993.1079","volume":"209","author":"Sreerama N.","year":"1993","journal-title":"Anal. Biochem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1021\/bi00508a007","volume":"20","author":"Hennessey J. P.","year":"1981","journal-title":"Biochemistry"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/bip.360221211","volume":"22","author":"Kabsch W.","year":"1983","journal-title":"Biopolymers"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0022-2836(77)90207-8","volume":"114","author":"Levitt M.","year":"1977","journal-title":"J. Mol. Biol."},{"key":"ref38\/cit38","volume-title":"Spark 3 NMR Analysis Software","author":"Goddard T. D.","year":"2001"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF00197809","volume":"6","author":"Delaglio F.","year":"1995","journal-title":"J. Biomol. NMR"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1073\/pnas.041606398","volume":"98","author":"Lu C.","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"23349","DOI":"10.1074\/jbc.M401292200","volume":"279","author":"Wigelsworth D. J.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1042\/bj20021273","volume":"372","author":"McCleverty C. J.","year":"2003","journal-title":"Biochem. J."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"38762","DOI":"10.1074\/jbc.C000563200","volume":"275","author":"Xiong J. P.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1462-5822.2006.00845.x","volume":"9","author":"Liu S.","year":"2007","journal-title":"Cell Microbiol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1371\/journal.pone.0000329","volume":"2","author":"Scobie H. M.","year":"2007","journal-title":"PLoS ONE"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0969-2126(01)00271-4","volume":"3","author":"Lee J. O.","year":"1995","journal-title":"Structure"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(95)90517-0","volume":"80","author":"Lee J. O.","year":"1995","journal-title":"Cell"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/77895","volume":"7","author":"Leitinger B.","year":"2000","journal-title":"Nat. Struct. Biol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.cell.2005.12.045","volume":"124","author":"Wei W.","year":"2006","journal-title":"Cell"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1371\/journal.ppat.0030027","volume":"3","author":"Young J. J.","year":"2007","journal-title":"PLoS Pathog."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"e1817","DOI":"10.1371\/journal.pone.0001817","volume":"3","author":"Ryan P. L.","year":"2008","journal-title":"PLoS ONE"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1111\/j.1462-5822.2008.01226.x","volume":"10","author":"Abrami L.","year":"2008","journal-title":"Cell Microbiol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0968-0004(97)01141-9","volume":"23","author":"Bazzoni G.","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.ceb.2003.08.003","volume":"15","author":"Carman C. V.","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ni1057","volume":"5","author":"Dustin M. L.","year":"2004","journal-title":"Nat. Immunol."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jmb.2006.04.072","volume":"360","author":"Go M. Y.","year":"2006","journal-title":"J. Mol. Biol."}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi100887w","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T15:03:54Z","timestamp":1680447834000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi100887w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,6]]},"references-count":56,"journal-issue":{"issue":"34","published-print":{"date-parts":[[2010,8,31]]}},"alternative-id":["10.1021\/bi100887w"],"URL":"https:\/\/doi.org\/10.1021\/bi100887w","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,6]]}}}