{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:08:05Z","timestamp":1784246885840,"version":"3.55.0"},"reference-count":64,"publisher":"American Chemical Society (ACS)","issue":"43","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2010,11,2]]},"DOI":"10.1021\/bi101336u","type":"journal-article","created":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T21:10:13Z","timestamp":1285362613000},"page":"9306-9317","source":"Crossref","is-referenced-by-count":33,"title":["Structure and Mechanism of ORF36, an Amino Sugar Oxidizing Enzyme in Everninomicin Biosynthesis,"],"prefix":"10.1021","volume":"49","author":[{"given":"Jessica L.","family":"Vey","sequence":"first","affiliation":[{"name":"Department of Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Al-Mestarihi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfeng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian O.","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Department of Biochemistry"},{"name":"Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. M.","family":"Iverson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology"},{"name":"Department of Biochemistry"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,10,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.7164\/antibiotics.53.1038","volume":"53","author":"Ganguly A. K.","year":"2000","journal-title":"J. Antibiot."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/jac\/47.1.15","volume":"47","author":"Jones R. N.","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1021\/np020093t","volume":"65","author":"Chu M.","year":"2002","journal-title":"J. Nat. Prod."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1128\/AAC.44.5.1121-1126.2000","volume":"44","author":"McNicholas P. M.","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref5\/cit5","volume-title":"Micromonospora carbonacea var. africana","author":"Waitz J. A.","year":"1988"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7164\/antibiotics.35.561","volume":"35","author":"Ganguly A. K.","year":"1982","journal-title":"J. Antibiot."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/01926230590925061","volume":"33","author":"Poulet F. M.","year":"2005","journal-title":"Toxicol. Pathol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"15756","DOI":"10.1021\/ja8051415","volume":"130","author":"Hu Y.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00203-007-0337-3","volume":"189","author":"Kim C. G.","year":"2008","journal-title":"Arch. Microbiol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1021\/ja0744854","volume":"129","author":"Zhang H.","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1021\/bi100318v","volume":"49","author":"Bruender N. A.","year":"2010","journal-title":"Biochemistry"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/abbi.1996.9857","volume":"339","author":"Parry R. J.","year":"1997","journal-title":"Arch. Biochem. Biophys."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/anie.200502903","volume":"45","author":"Lee J.","year":"2006","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/cbic.200600136","volume":"7","author":"Simurdiak M.","year":"2006","journal-title":"ChemBioChem"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"13608","DOI":"10.1021\/ja9064969","volume":"131","author":"Korboukh V. K.","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1021\/cr020443g","volume":"104","author":"Meunier B.","year":"2004","journal-title":"Chem. Rev."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"17662","DOI":"10.1021\/ja807557a","volume":"130","author":"Johnson H. D.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.tips.2008.03.004","volume":"29","author":"Phillips I. R.","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1021\/bi900442z","volume":"48","author":"Meneely K. M.","year":"2009","journal-title":"Biochemistry"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jbiotec.2006.03.044","volume":"124","author":"van Berkel W. J.","year":"2006","journal-title":"J. Biotechnol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1096\/fasebj.9.9.7601336","volume":"9","author":"Thorpe C.","year":"1995","journal-title":"FASEB J."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1989.tb14688.x","volume":"181","author":"Ghisla S.","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.abb.2009.11.028","volume":"493","author":"Palfey B. A.","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1073\/pnas.0608381104","volume":"104","author":"Alfieri A.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"33107","DOI":"10.1074\/jbc.M703440200","volume":"282","author":"Kim S. H.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1074\/jbc.M109.056135","volume":"285","author":"Webb B. N.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"22264","DOI":"10.1074\/jbc.M109.099028","volume":"285","author":"Dresen C.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.bbrc.2005.09.081","volume":"338","author":"Ballou D. P.","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"17044","DOI":"10.1074\/jbc.M512385200","volume":"281","author":"Sucharitakul J.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"11942","DOI":"10.1073\/pnas.210395097","volume":"97","author":"Chen H.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1021\/ja0562144","volume":"128","author":"Takahashi H.","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/0006-291X(91)91495-X","volume":"174","author":"Romana L. K.","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Otwinowski Z.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"McCoy A. J.","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"ref35\/cit35","unstructured":"Pike, A. C. W., Hozjan, V., Smee, C., Niesen, F. H., Kavanagh, K. L., Umeano, C., Turnbull, A. P., Von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C. H., Sundstrom, M., and Oppermann, U. (2010) Crystal structure of human short-branched chain acyl-coA dehydrogenase. Manuscript being prepared for publication."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/jsbi.1999.4094","volume":"125","author":"McRee D. E.","year":"1999","journal-title":"J. Struct. Biol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0108767398011465","volume":"54","author":"Brunger A. T.","year":"1998","journal-title":"Acta Crystallogr."},{"key":"ref38\/cit38","volume-title":"The PyMOL Molecular Graphics System","author":"DeLano W. L.","year":"2002"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","volume":"24","author":"Kraulis P. J.","year":"1991","journal-title":"J. Appl. Crystallogr."},{"key":"ref40\/cit40","first-page":"869","volume":"50","author":"Merritt E. A.","year":"1994","journal-title":"Acta Crystallogr."},{"key":"ref41\/cit41","first-page":"94","volume":"63","author":"Kleywegt G. J.","year":"2007","journal-title":"Acta Crystallogr."},{"key":"ref42\/cit42","first-page":"406","volume":"4","author":"Saitou N.","year":"1987","journal-title":"Mol. Biol. Evol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2307\/2408678","volume":"39","author":"Felsenstein J.","year":"1985","journal-title":"Evolution"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/B978-1-4832-2734-4.50017-6","volume-title":"Evolving Genes and Proteins","author":"Zuckerkandl E.","year":"1965"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","volume":"24","author":"Tamura K.","year":"2007","journal-title":"Mol. Biol. Evol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"D25","DOI":"10.1093\/nar\/gkm929","volume":"36","author":"Benson D. A.","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.cbpa.2008.03.017","volume":"12","author":"Timmons S. C.","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1039\/c39730000827","author":"Chow Y. L.","year":"1973","journal-title":"J. Chem. Soc., Chem. Commun.,"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1093\/bioinformatics\/btn507","volume":"24","author":"Holm L.","year":"2008","journal-title":"Bioinformatics"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/bi951344i","volume":"35","author":"Gatti D. L.","year":"1996","journal-title":"Biochemistry"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jmb.2009.09.003","volume":"393","author":"Lindqvist Y.","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1021\/bi900149f","volume":"48","author":"McCulloch K. M.","year":"2009","journal-title":"Biochemistry"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"26297","DOI":"10.1074\/jbc.R800034200","volume":"283","author":"Johnson K. A.","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/prot.22223","volume":"75","author":"Weikl T. R.","year":"2009","journal-title":"Proteins"},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"22459","DOI":"10.1016\/S0021-9258(17)31664-2","volume":"269","author":"Massey V.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ijch.198400008","volume":"24","author":"Bruice T. C.","year":"1984","journal-title":"Isr. J. Chem."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tibs.2006.03.003","volume":"31","author":"Mattevi A.","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1021\/bi00007a009","volume":"34","author":"Djordjevic S.","year":"1995","journal-title":"Biochemistry"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1073\/pnas.90.16.7523","volume":"90","author":"Kim J. J.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/jb\/mvg143","volume":"134","author":"Satoh A.","year":"2003","journal-title":"J. Biochem."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"12200","DOI":"10.1074\/jbc.M111296200","volume":"277","author":"Battaile K. P.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref62\/cit62","unstructured":"Chang, C., Skarina, T., Kagan, O., Savchenko, A., Edwards, A. M., and Joachimiak, A. (2010) Crystal structure of 3-HSA hydroxylase, oxygenase fromRhodococcussp. RHA1. Manuscript being prepared for publication."},{"key":"ref63\/cit63","unstructured":"Tan, K., Skarina, T., Kagen, O., Savchenko, A., Edwards, A., and Joachimiak, A. (2010) The crystal structure of a putative hydroxylase fromRhodococcussp. RHA1.Manuscript being prepared for publication."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1021\/bi051966w","volume":"45","author":"Nagpal A.","year":"2006","journal-title":"Biochemistry"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi101336u","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T00:22:35Z","timestamp":1680913355000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi101336u"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,8]]},"references-count":64,"journal-issue":{"issue":"43","published-print":{"date-parts":[[2010,11,2]]}},"alternative-id":["10.1021\/bi101336u"],"URL":"https:\/\/doi.org\/10.1021\/bi101336u","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,8]]}}}