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Ser."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2174\/092986730607220401121825","volume":"6","author":"Zhang R.","year":"1999","journal-title":"Curr. Med. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"6990","DOI":"10.1021\/bi9607416","volume":"35","author":"Fleming M. A.","year":"1996","journal-title":"Biochemistry"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1021\/ja9534056","volume":"118","author":"Link J. O.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1021\/bi992288e","volume":"39","author":"Digits J. A.","year":"2000","journal-title":"Biochemistry"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1073\/pnas.0304686101","volume":"101","author":"Striepen B.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. 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Dis."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/prep.2001.1603","volume":"25","author":"Stols L.","year":"2002","journal-title":"Protein Expression Purif."},{"key":"ref43\/cit43","first-page":"1168","volume":"55","author":"Walsh M. A.","year":"1999","journal-title":"Acta Crystallogr."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10969-010-9082-y","volume":"11","author":"Eschenfeldt W.","year":"2010","journal-title":"J. Struct. Funct. Genomics"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1110\/ps.8.4.921","volume":"8","author":"Beckett D.","year":"1999","journal-title":"Protein Sci."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ymeth.2011.07.010","volume":"55","author":"Kim Y.","year":"2011","journal-title":"Methods"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1107\/S0909049505036721","volume":"13","author":"Rosenbaum G.","year":"2006","journal-title":"J. Synchrotron Radiat."},{"key":"ref48\/cit48","first-page":"859","volume":"62","author":"Minor W.","year":"2006","journal-title":"Acta Crystallogr."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1107\/S0108767302000934","volume":"58","author":"Schneider T. R.","year":"2002","journal-title":"Acta Crystallogr."},{"key":"ref50\/cit50","first-page":"122","volume":"57","author":"Winn M. D.","year":"2001","journal-title":"Acta Crystallogr."},{"key":"ref51\/cit51","first-page":"34","author":"Cowtan K.","year":"1994","journal-title":"Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography,"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0076-6879(03)74011-7","volume":"374","author":"Morris R. J.","year":"2003","journal-title":"Methods Enzymol."},{"key":"ref53\/cit53","first-page":"2126","volume":"60","author":"Emsley P.","year":"2004","journal-title":"Acta Crystallogr."},{"key":"ref54\/cit54","first-page":"760","volume":"50","author":"Collaborative Computational Project, Number 4","year":"1994","journal-title":"Acta Crystallogr."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S010876731009968X","volume":"66","author":"Adams P. D.","year":"2010","journal-title":"Acta Crystallogr."},{"key":"ref56\/cit56","first-page":"240","volume":"53","author":"Murshudov G. 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