{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:05:00Z","timestamp":1787000700390,"version":"build-2736575974"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"47","funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["R01-GM030804"],"award-info":[{"award-number":["R01-GM030804"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2013,11,26]]},"DOI":"10.1021\/bi401126z","type":"journal-article","created":{"date-parts":[[2013,11,13]],"date-time":"2013-11-13T11:29:51Z","timestamp":1384342191000},"page":"8539-8555","source":"Crossref","is-referenced-by-count":32,"title":["Hemoglobin Bohr Effects: Atomic Origin of the Histidine Residue Contributions"],"prefix":"10.1021","volume":"52","author":[{"given":"Guishan","family":"Zheng","sequence":"first","affiliation":[{"name":"Department\rof Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Novartis Institutes for BioMedical Research, Klybeckstrasse 141, 4053 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Karplus","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States"},{"name":"Laboratoire\rde Chimie Biophysique, ISIS Universite de Strasbourg, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,11,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1146\/annurev.bi.39.070170.004553","volume":"39","author":"Antonini E.","year":"1970","journal-title":"Annu. Rev. Biochem."},{"key":"ref2\/cit2","first-page":"713","author":"Bohr C.","year":"1903","journal-title":"Zentralblatt F\u00fcr Physiologie"},{"key":"ref3\/cit3","first-page":"404","volume":"16","author":"Bohr C.","year":"1904","journal-title":"Skandinavisches Archiv Fur Physiologie"},{"key":"ref4\/cit4","first-page":"226","volume":"39","author":"Edsall J. T.","year":"1980","journal-title":"Federation Proceedings"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1113\/jphysiol.1914.sp001659","volume":"48","author":"Christiansen J.","year":"1914","journal-title":"Journal of Physiology-London"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/bmb.20629","volume":"40","author":"Brunori M.","year":"2012","journal-title":"Biochem. Mol. Biol. Educ."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0065-3233(08)60189-8","volume":"19","author":"Rossifanelli A.","year":"1964","journal-title":"Adv. Protein Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1152\/physrev.1973.53.4.836","volume":"53","author":"Kilmartin J.","year":"1973","journal-title":"Physiol. Rev."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.ph.50.030188.001145","volume":"50","author":"Riggs A. F.","year":"1988","journal-title":"Annu. Rev. Physiol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/228726a0","volume":"228","author":"Perutz M. F.","year":"1970","journal-title":"Nature"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1101\/SQB.1972.036.01.040","volume":"36","author":"Perutz M. F.","year":"1970","journal-title":"Cold Spring Harbor Symp. Quantum Biol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0022-2836(72)90077-0","volume":"72","author":"Szabo A.","year":"1972","journal-title":"J. Mol. Biol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0006-291X(72)80219-5","volume":"46","author":"Szabo A.","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0022-2836(65)80285-6","volume":"12","author":"Monod J.","year":"1965","journal-title":"J. Mol. Biol."},{"key":"ref15\/cit15","first-page":"185","volume":"48","author":"Roughton F. J. W.","year":"1965","journal-title":"Hvalradets Skrifter"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"7055","DOI":"10.1073\/pnas.80.23.7055","volume":"80","author":"Lee A. W. M.","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","DOI":"10.1016\/S0301-4622(02)00091-1","volume":"98","author":"Henry E. R.","year":"2002","journal-title":"Biophys. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1080\/15216540701272380","volume":"59","author":"Eaton W. A.","year":"2007","journal-title":"IUBMB Life"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","unstructured":"Ho, C. and Yuan, Y.Haemoglobin: Cooperativity in Protein-Ligand Interactions; Encyclopedia of Life Sciences ed.John Wiley Sons, Ltd, 2010; pp1\u20136.","DOI":"10.1002\/9780470015902.a0001345.pub2"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"13423","DOI":"10.1021\/bi9911379","volume":"38","author":"Fang T.-Y.","year":"1999","journal-title":"Biochemistry"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"10219","DOI":"10.1021\/bi00496a010","volume":"29","author":"Bashford D.","year":"1990","journal-title":"Biochemistry"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1021\/j100167a045","volume":"95","author":"Lim C.","year":"1991","journal-title":"J. Phys. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"8045","DOI":"10.1021\/bi00082a027","volume":"32","author":"Bashford D.","year":"1993","journal-title":"Biochemistry"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1006\/jmbi.1994.1301","volume":"238","author":"Antosiewicz J.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/prot.340150304","volume":"15","author":"Yang A. S.","year":"1993","journal-title":"Proteins"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1021\/jp962972s","volume":"101","author":"Schaefer M.","year":"1997","journal-title":"J. Phys. Chem. B"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1021\/ja039788m","volume":"126","author":"Simonson T.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"17715","DOI":"10.1021\/jp0517192","volume":"109","author":"Riccardi D.","year":"2005","journal-title":"J. Phys. Chem. B"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"20227","DOI":"10.1073\/pnas.0810631106","volume":"105","author":"Zheng L.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1529\/biophysj.105.061341","volume":"89","author":"Khandogin J.","year":"2005","journal-title":"Biophys. J."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1002\/prot.23195","volume":"79","author":"Arthur E. J.","year":"2011","journal-title":"Proteins"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"19393","DOI":"10.1021\/ja2060066","volume":"133","author":"Zhang B. W.","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref33\/cit33","first-page":"91","volume":"18","author":"Matthew J. B.","year":"1985","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"ref34\/cit34","unstructured":"Sommers, M.Electrostatic modeling of biological macromolecules in solution; Ph.D. thesis;Harvard University, 1995."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0263-7855(90)80070-V","volume":"8","author":"Vriend G.","year":"1990","journal-title":"J. Mol. Graphics Modell."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"9556","DOI":"10.1021\/j100176a093","volume":"95","author":"Bashford D.","year":"1991","journal-title":"J. Phys. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/bip.1976.360150215","volume":"15","author":"Tanokura M.","year":"1976","journal-title":"Biopolymers"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.1021\/bi00238a003","volume":"30","author":"Bash P. A.","year":"1991","journal-title":"Biochemistry"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1021\/ja0118439","volume":"124","author":"Cui Q.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks B. R.","year":"1983","journal-title":"J. Comput. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"12708","DOI":"10.1063\/1.1627754","volume":"119","author":"Chu J. W.","year":"2003","journal-title":"J. Chem. Phys."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/jcc.21287","volume":"30","author":"Brooks B. R.","year":"2009","journal-title":"J. Comput. Chem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0010-4655(91)90094-2","volume":"62","author":"Davis M. E.","year":"1991","journal-title":"Comput. Phys. Commun."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1073\/pnas.88.13.5804","volume":"88","author":"Beroza P.","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jmb.2006.05.036","volume":"360","author":"Park S.-Y.","year":"2006","journal-title":"J. Mol. Biol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-2836(83)80313-1","volume":"171","author":"Shaanan B.","year":"1983","journal-title":"J. Mol. Biol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"17248","DOI":"10.1016\/S0021-9258(18)41919-9","volume":"267","author":"Silva M.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1021\/bi050412q","volume":"44","author":"Safo M.","year":"2005","journal-title":"Biochemistry"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/pro.5560070314","volume":"7","author":"Caves L. S. D.","year":"1998","journal-title":"Protein Sci."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1152\/physrev.1973.53.4.836","volume":"53","author":"Kilmarti J. V.","year":"1973","journal-title":"Physiol. Rev."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1021\/bi00147a004","volume":"31","author":"Rao M. J.","year":"1992","journal-title":"Biochemistry"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1021\/ar010030m","volume":"35","author":"Simonson T.","year":"2002","journal-title":"Acc. Chem. Res."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","volume":"98","author":"Baker N.","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1021\/jp9521621","volume":"100","author":"Schaefer M.","year":"1996","journal-title":"J. Phys. Chem."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1006\/jmbi.1998.2172","volume":"284","author":"Schaefer M.","year":"1998","journal-title":"J. Mol. Biol."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0022-2836(84)90472-8","volume":"175","author":"Fermi G.","year":"1984","journal-title":"J. Mol. Biol."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1021\/bi00061a007","volume":"32","author":"Kavanaugh J.","year":"1993","journal-title":"Biochemistry"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1021\/bi030172j","volume":"43","author":"Chan N.","year":"2004","journal-title":"Biochemistry"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"6101","DOI":"10.1021\/bi047813a","volume":"44","author":"Kavanaugh J.","year":"2005","journal-title":"Biochemistry"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi401126z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T15:02:48Z","timestamp":1682175768000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi401126z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,13]]},"references-count":59,"journal-issue":{"issue":"47","published-print":{"date-parts":[[2013,11,26]]}},"alternative-id":["10.1021\/bi401126z"],"URL":"https:\/\/doi.org\/10.1021\/bi401126z","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,13]]}}}