{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T02:00:58Z","timestamp":1783562458434,"version":"3.55.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"3","funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG0918401DMC"],"award-info":[{"award-number":["RSG0918401DMC"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2015,1,27]]},"DOI":"10.1021\/bi501357c","type":"journal-article","created":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T17:23:03Z","timestamp":1418923383000},"page":"807-819","source":"Crossref","is-referenced-by-count":7,"title":["<i>Man o\u2019 War<\/i> Mutation in UDP-\u03b1-<scp>d<\/scp>-Xylose Synthase Favors the Abortive Catalytic Cycle and Uncovers a Latent Potential for Hexamer Formation"],"prefix":"10.1021","volume":"54","author":[{"suffix":"Jr.","given":"Richard M.","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Biochemistry\rand Molecular Biology, University of Georgia, Athens, Georgia 30602, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Polizzi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\rand Molecular Biology, University of Georgia, Athens, Georgia 30602, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Kadirvelraj","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\rand Molecular Biology, University of Georgia, Athens, Georgia 30602, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley W.","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\rand Molecular Biology, University of Georgia, Athens, Georgia 30602, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary A.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Biochemistry\rand Molecular Biology, University of Georgia, Athens, Georgia 30602, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2015,1,13]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/15216540214923","volume":"54","author":"Silbert J. E.","year":"2002","journal-title":"IUBMB Life"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nrc1649","volume":"5","author":"Fuster M. M.","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1002\/bies.20612","volume":"29","author":"Lamoureux F.","year":"2007","journal-title":"BioEssays"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"48189","DOI":"10.1074\/jbc.M107339200","volume":"276","author":"Bai X.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/15216540214928","volume":"54","author":"Sugahara K.","year":"2002","journal-title":"IUBMB Life"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ydbio.2010.02.035","volume":"341","author":"Eames B. F.","year":"2010","journal-title":"Dev. Biol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1126\/science.3137658","volume":"241","author":"Esko J. D.","year":"1988","journal-title":"Science"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1073\/pnas.012346499","volume":"99","author":"Belting M.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"11097","DOI":"10.1016\/S0021-9258(18)82097-X","volume":"268","author":"Kearns A. E.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"14224","DOI":"10.1073\/pnas.172522499","volume":"99","author":"Hwang H. Y.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"16968","DOI":"10.1074\/jbc.M109316200","volume":"277","author":"Moriarity J. L.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"8844","DOI":"10.1021\/bi301135b","volume":"51","author":"Polizzi S. J.","year":"2012","journal-title":"Biochemistry"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1021\/bi0345079","volume":"42","author":"Field R. A.","year":"2003","journal-title":"Biochemistry"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1007\/s00018-008-8588-y","volume":"65","author":"Kavanagh K. L.","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1021\/bi400294e","volume":"52","author":"Polizzi S. J.","year":"2013","journal-title":"Biochemistry"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","volume":"66","author":"Kabsch W.","year":"2010","journal-title":"Acta Crystallogr., Sect. D"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0076-6879(97)77021-6","volume":"277","author":"Brunger A. T.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1218231","volume":"336","author":"Karplus P. A.","year":"2012","journal-title":"Science"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"McCoy A. J.","year":"2007","journal-title":"J. Appl. Crystallogr."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","volume":"66","author":"Adams P. D.","year":"2010","journal-title":"Acta Crystallogr., Sect. D: Biol. Cryst."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley P.","year":"2004","journal-title":"Acta Crystallogr., Sect. D.: Biol. Cryst."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1093-3263(02)00140-7","volume":"21","author":"Hayward S.","year":"2002","journal-title":"J. Mol. Graphics Modell."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jmb.2007.05.022","volume":"372","author":"Krissinel E.","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/jmbi.1999.2697","volume":"288","author":"Bruns C. M.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"ref25\/cit25","first-page":"90","volume-title":"Analytical Ultracentrifugation in Biochemistry and Polymer Science","author":"Laue T. M.","year":"1992"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1529\/biophysj.106.081372","volume":"90","author":"Brown P. H.","year":"2006","journal-title":"Biophys. J."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.bpj.2011.06.046","volume":"101","author":"Ortega A.","year":"2011","journal-title":"Biophys. J."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0003-2697(03)00289-6","volume":"320","author":"Schuck P.","year":"2003","journal-title":"Anal. Biochem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ymeth.2011.01.010","volume":"54","author":"Zhao H.","year":"2011","journal-title":"Methods"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"10675","DOI":"10.1021\/bi970430a","volume":"36","author":"Liu Y.","year":"1997","journal-title":"Biochemistry"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"31349","DOI":"10.1074\/jbc.M112.386706","volume":"287","author":"Eixelsberger T.","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"e00043","DOI":"10.1042\/BSR20130017","volume":"33","author":"Miyafusa T.","year":"2013","journal-title":"Biosci. Rep."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"24489","DOI":"10.1074\/jbc.M602393200","volume":"281","author":"Ishiyama N.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"11363","DOI":"10.1021\/bi00093a013","volume":"32","author":"Blaber M.","year":"1993","journal-title":"Biochemistry"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/pro.5560030514","volume":"3","author":"Chakrabartty A.","year":"1994","journal-title":"Protein Sci."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0006-3495(98)77529-0","volume":"75","author":"Pace C. N.","year":"1998","journal-title":"Biophys. J."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"8013","DOI":"10.1016\/S0021-9258(17)40927-6","volume":"252","author":"John K. V.","year":"1977","journal-title":"J. Biol. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"6707","DOI":"10.1016\/S0021-9258(17)39906-4","volume":"252","author":"John K. V.","year":"1977","journal-title":"J. Biol. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nsb0497-269","volume":"4","author":"Diederichs K.","year":"1997","journal-title":"Nat. Struct. Biol."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1107\/S0021889897003907","volume":"30","author":"Weiss M. S.","year":"1997","journal-title":"J. Appl. Crystallogr."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1107\/S0021889800018227","volume":"34","author":"Weiss M. S.","year":"2001","journal-title":"J. Appl. Crystallogr."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0969-2126(01)00694-3","volume":"10","author":"Allard S. T.","year":"2002","journal-title":"Structure"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"15578","DOI":"10.1021\/bi0266683","volume":"41","author":"Mulichak A. M.","year":"2002","journal-title":"Biochemistry"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/bi035547f","volume":"43","author":"Vogan E. M.","year":"2004","journal-title":"Biochemistry"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"11872","DOI":"10.1021\/ja035796r","volume":"125","author":"Beis K.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.jmb.2007.09.055","volume":"374","author":"King J. D.","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1107\/S1744309106028740","volume":"62","author":"Alphey M. S.","year":"2006","journal-title":"Acta Crystallogr., Sect. F: Struct. Biol. Cryst. Commun."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"5691","DOI":"10.1021\/bi000215l","volume":"39","author":"Thoden J. B.","year":"2000","journal-title":"Biochemistry"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"13097","DOI":"10.1073\/pnas.96.23.13097","volume":"96","author":"Mulichak A. M.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi501357c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T09:47:26Z","timestamp":1680428846000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi501357c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,13]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,1,27]]}},"alternative-id":["10.1021\/bi501357c"],"URL":"https:\/\/doi.org\/10.1021\/bi501357c","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,13]]}}}