{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:21:44Z","timestamp":1781277704305,"version":"3.54.1"},"reference-count":69,"publisher":"American Chemical Society (ACS)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2007,4,1]]},"DOI":"10.1021\/bi602461y","type":"journal-article","created":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T11:44:55Z","timestamp":1174650295000},"page":"4499-4509","source":"Crossref","is-referenced-by-count":93,"title":["\u03b1-Synuclein Multistate Folding Thermodynamics:\u2009 Implications for Protein Misfolding and Aggregation"],"prefix":"10.1021","volume":"46","author":[{"given":"Allan Chris M.","family":"Ferreon","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines MB-19, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok A.","family":"Deniz","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines MB-19, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"bi602461yb00001\/bi602461yb00001_1","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.08-08-02804.1988","volume":"8","author":"Maroteaux L.","year":"1988","journal-title":"J. Neurosci."},{"key":"bi602461yb00002\/bi602461yb00002_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0014-5793(94)00395-5","volume":"345","author":"Jakes R.","year":"1994","journal-title":"FEBS Lett."},{"key":"bi602461yb00003\/bi602461yb00003_1","volume-title":"Biochemistry 35, 13709\u221213715.","author":"Weinreb P. H.","year":"1996"},{"key":"bi602461yb00004\/bi602461yb00004_1","volume-title":"Science 276","author":"Polymeropoulos M. H.","year":"1997"},{"key":"bi602461yb00005\/bi602461yb00005_1","volume-title":"Nat. Genet. 18, 106\u2212108.","author":"Kruger R.","year":"1998"},{"key":"bi602461yb00006\/bi602461yb00006_1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1090278","volume":"302","author":"Singleton A. B.","year":"2003","journal-title":"Science"},{"key":"bi602461yb00007\/bi602461yb00007_1","volume-title":"Neuron 40, 453\u2212456.","author":"Eriksen J. L.","year":"2003"},{"key":"bi602461yb00008\/bi602461yb00008_1","volume-title":"Science 302, 819\u2212822.","author":"Dawson T. M.","year":"2003"},{"key":"bi602461yb00009\/bi602461yb00009_1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM2003ra020003","volume":"348","author":"Nussbaum R. L.","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"bi602461yb00010\/bi602461yb00010_1","volume-title":"Nature 388, 839\u2212840.","author":"Spillantini M. G.","year":"1997"},{"key":"bi602461yb00011\/bi602461yb00011_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 95","author":"Spillantini M. G.","year":"1998"},{"key":"bi602461yb00012\/bi602461yb00012_1","first-page":"44","volume":"45","author":"Dev K. K.","year":"2003","journal-title":"Neuropharmacology"},{"key":"bi602461yb00013\/bi602461yb00013_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.archger.2003.11.003","volume":"39","author":"Rampello L.","year":"2004","journal-title":"Arch. Gerontol. Geriatr."},{"key":"bi602461yb00014\/bi602461yb00014_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 90","author":"Ueda K.","year":"1993"},{"key":"bi602461yb00015\/bi602461yb00015_1","volume-title":"Neuron 25, 239\u2212252.","author":"Abeliovich A.","year":"2000"},{"key":"bi602461yb00016\/bi602461yb00016_1","volume":"20","author":"Murphy D. D.","year":"2000","journal-title":"J. Neurosci."},{"key":"bi602461yb00017\/bi602461yb00017_1","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.22-20-08797.2002","volume":"22","author":"Cabin D. E.","year":"2002","journal-title":"J. Neurosci."},{"key":"bi602461yb00018\/bi602461yb00018_1","volume-title":"Hum. Mol. Genet. 11, 2395\u22122407.","author":"Lotharius J.","year":"2002"},{"key":"bi602461yb00019\/bi602461yb00019_1","volume-title":"Cell 123, 383\u2212396.","author":"Chandra S.","year":"2005"},{"key":"bi602461yb00020\/bi602461yb00020_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1471-4159.2004.02423.x","volume":"89","author":"Perez R. G.","year":"2004","journal-title":"J. Neurochem."},{"key":"bi602461yb00021\/bi602461yb00021_1","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.0096-06.2006","volume":"26","author":"Leng Y.","year":"2006","journal-title":"J. Neurosci."},{"key":"bi602461yb00022\/bi602461yb00022_1","volume-title":"Science 313, 324\u2212328.","author":"Cooper A. A.","year":"2006"},{"key":"bi602461yb00023\/bi602461yb00023_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0014-5793(02)02883-1","volume":"522","author":"Uversky V. N.","year":"2002","journal-title":"FEBS Lett."},{"key":"bi602461yb00024\/bi602461yb00024_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 101","author":"Jao C. C.","year":"2004"},{"key":"bi602461yb00025\/bi602461yb00025_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.16.9443","volume":"273","author":"Davidson W. S.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00026\/bi602461yb00026_1","volume":"278","author":"Chandra S.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00027\/bi602461yb00027_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M305266200","volume":"278","author":"Der-Sarkissian A.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00028\/bi602461yb00028_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 102","author":"Heise H.","year":"2005"},{"key":"bi602461yb00029\/bi602461yb00029_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 102, 15477\u221215482.","author":"Del Mar C.","year":"2005"},{"key":"bi602461yb00030\/bi602461yb00030_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 97","author":"Serpell L. C.","year":"2000"},{"key":"bi602461yb00031\/bi602461yb00031_1","volume-title":"Biochemistry 43, 16233\u221216242.","author":"Hoyer W.","year":"2004"},{"key":"bi602461yb00032\/bi602461yb00032_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 102","author":"Li W.","year":"2005"},{"key":"bi602461yb00033\/bi602461yb00033_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 102","author":"Bertoncini C. W.","year":"2005"},{"key":"bi602461yb00034\/bi602461yb00034_1","volume-title":"Why are \u201cnatively unfolded","author":"Uversky V. N.","year":"2000"},{"key":"bi602461yb00035\/bi602461yb00035_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0014-5793(98)01146-6","volume":"436","author":"Crowther R. A.","year":"1998","journal-title":"FEBS Lett."},{"key":"bi602461yb00036\/bi602461yb00036_1","doi-asserted-by":"crossref","unstructured":"Conway, K. A., Harper, J. D., and Lansbury, P. T., Jr. (2000) Fibrils formed in vitro from \u03b1-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid,Biochemistry 39, 2552\u22122563.","DOI":"10.1021\/bi991447r"},{"key":"bi602461yb00037\/bi602461yb00037_1","doi-asserted-by":"crossref","unstructured":"Conway, K. A., Harper, J. D., and Lansbury, P. T. (1998) Accelerated in vitro fibril formation by a mutant \u03b1-synuclein linked to early-onset Parkinson disease,Nat. Med. 4, 1318\u22121320.","DOI":"10.1038\/3311"},{"key":"bi602461yb00038\/bi602461yb00038_1","volume":"274","author":"Wood S. J.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00039\/bi602461yb00039_1","volume":"276","author":"Uversky V. N.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00040\/bi602461yb00040_1","volume-title":"Acc. Chem. Res. 39, 628\u2212634.","author":"Fink A. L.","year":"2006"},{"key":"bi602461yb00041\/bi602461yb00041_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 66","author":"Reynolds J. A.","year":"1970"},{"key":"bi602461yb00042\/bi602461yb00042_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)62831-5","volume":"245","author":"Reynolds J. A.","year":"1970","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00043\/bi602461yb00043_1","volume":"280","author":"Ulmer T. S.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00044\/bi602461yb00044_1","volume":"280","author":"Ulmer T. S.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00045\/bi602461yb00045_1","volume-title":"Biochemistry 44, 329\u2212339.","author":"Bisaglia M.","year":"2005"},{"key":"bi602461yb00046\/bi602461yb00046_1","volume":"277","author":"Cole N. B.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00047\/bi602461yb00047_1","volume-title":"Anal. Biochem. 182, 319\u2212326.","author":"Gill S. C.","year":"1989"},{"key":"bi602461yb00048\/bi602461yb00048_1","volume-title":"Biochemistry 6","author":"Edelhoch H.","year":"1967"},{"key":"bi602461yb00049\/bi602461yb00049_1","volume-title":"Protein Sci. 4, 2411\u22122423.","author":"Pace C. N.","year":"1995"},{"key":"bi602461yb00050\/bi602461yb00050_1","volume-title":"Anal. Biochem. 179, 131\u2212137.","author":"Wiseman T.","year":"1989"},{"key":"bi602461yb00051\/bi602461yb00051_1","volume-title":"Methods Enzymol. 56, 734\u2212749.","author":"Helenius A.","year":"1979"},{"key":"bi602461yb00052\/bi602461yb00052_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0006-3495(02)73982-9","volume":"83","author":"Otzen D. E.","year":"2002","journal-title":"Biophys. J."},{"key":"bi602461yb00053\/bi602461yb00053_1","doi-asserted-by":"crossref","DOI":"10.1021\/pr034094y","volume":"3","author":"Kuznetsova I. M.","year":"2004","journal-title":"J. Proteome Res."},{"key":"bi602461yb00054\/bi602461yb00054_1","volume-title":"Protein Sci. 4, 2138\u22122148.","author":"Myers J. K.","year":"1995"},{"key":"bi602461yb00055\/bi602461yb00055_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-2836(03)00246-8","volume":"328","author":"Rosgen J.","year":"2003","journal-title":"J. Mol. Biol."},{"key":"bi602461yb00056\/bi602461yb00056_1","doi-asserted-by":"crossref","DOI":"10.1529\/biophysj.106.092262","volume":"92","author":"Ferreon A. C.","year":"2007","journal-title":"Biophys. J."},{"key":"bi602461yb00057\/bi602461yb00057_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 103","author":"Gudiksen K. L.","year":"2006"},{"key":"bi602461yb00058\/bi602461yb00058_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.2001.5300","volume":"315","author":"Otzen D. E.","year":"2002","journal-title":"J. Mol. Biol."},{"key":"bi602461yb00059\/bi602461yb00059_1","volume-title":"Biochemistry 45, 11523\u221211531.","author":"de Laureto P. P.","year":"2006"},{"key":"bi602461yb00060\/bi602461yb00060_1","volume":"275","author":"Jo E.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"bi602461yb00061\/bi602461yb00061_1","volume-title":"Biochemistry 42, 2720\u22122730.","author":"Munishkina L. A.","year":"2003"},{"key":"bi602461yb00062\/bi602461yb00062_1","volume-title":"ChemPhysChem 4, 1065\u22121072.","author":"Fernandez P.","year":"2003"},{"key":"bi602461yb00063\/bi602461yb00063_1","volume":"329","author":"Bussell R., Jr.","year":"2003","journal-title":"J. Mol. Biol."},{"key":"bi602461yb00064\/bi602461yb00064_1","volume-title":"Nature 426, 884\u2212890.","author":"Dobson C. M.","year":"2003"},{"key":"bi602461yb00065\/bi602461yb00065_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/418291a","volume":"418","author":"Lashuel H. A.","year":"2002","journal-title":"Nature"},{"key":"bi602461yb00066\/bi602461yb00066_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-2836(02)00735-0","volume":"322","author":"Lashuel H. A.","year":"2002","journal-title":"J. Mol. Biol."},{"key":"bi602461yb00067\/bi602461yb00067_1","author":"Lashuel H. A.","year":"2006","journal-title":"Rev. Biophys., 1\u221235."},{"key":"bi602461yb00068\/bi602461yb00068_1","volume-title":"Biochemistry 42, 7871\u22127878.","author":"Volles M. J.","year":"2003"},{"key":"bi602461yn00001\/bi602461yn00001_1","volume-title":"circular dichroism","author":"Abbreviations CD"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi602461y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T19:36:54Z","timestamp":1678131414000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi602461y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,23]]},"references-count":69,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2007,4,1]]}},"alternative-id":["10.1021\/bi602461y"],"URL":"https:\/\/doi.org\/10.1021\/bi602461y","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3,23]]}}}