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Lett."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/jm0512600","volume":"49","author":"Nishimori I.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/14756360410001689577","volume":"19","author":"Reungprapavut S.","year":"2004","journal-title":"J. Enzyme Inhib. Med. Chem"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.bmc.2004.10.015","volume":"13","author":"Krungkrai J.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0306-9877(98)90172-4","volume":"50","author":"Sein K. K.","year":"1998","journal-title":"Med. 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Rev."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1001\/archopht.1977.04450080088009","volume":"95","author":"Epstein D. L.","year":"1977","journal-title":"Arch. Ophthalmol."},{"key":"ref43\/cit43","first-page":"1563","volume":"11","author":"Wallace T. R.","year":"1979","journal-title":"Ann. Ophthalmol."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0002-9394(14)75247-X","volume":"85","author":"Lichter P. R.","year":"1978","journal-title":"Am. J. Opthalmol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0161-6420(81)35040-4","volume":"88","author":"Lichter P. R.","year":"1981","journal-title":"Ophthalmology"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM200401153500318","volume":"350","author":"Saxon A.","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1056\/NEJMp038145","volume":"349","author":"Ray W. A.","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1056\/NEJMoa022963","volume":"349","author":"Strom B. L.","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1021\/bi00855a005","volume":"6","author":"Pocker Y.","year":"1967","journal-title":"Biochemistry"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1016\/S0021-9258(18)95800-X","volume":"242","author":"Verpoorte J. A.","year":"1967","journal-title":"J. Biol. Chem."},{"key":"ref51\/cit51","first-page":"149","volume":"47","author":"Pocker Y.","year":"1978","journal-title":"Adv. Enzymol. Relat. Areas Mol. Biol."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1046\/j.1432-1327.1999.00400.x","volume":"262","author":"Elleby B.","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"o395","DOI":"10.1107\/S0108270104008236","volume":"60","author":"Byres M.","year":"2004","journal-title":"Acta Crystallogr. C"},{"key":"ref54\/cit54","first-page":"824","volume":"20","author":"Wildfeuer A.","year":"1970","journal-title":"Arzneimittelforschung"},{"key":"ref55\/cit55","first-page":"39","volume":"76","author":"Lius V.","year":"1979","journal-title":"Lakartidningen"},{"key":"ref56\/cit56","first-page":"1298","volume":"19","author":"Goeth H.","year":"1969","journal-title":"Arzneimittelforschung"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1600-0536.1981.tb04048.x","volume":"7","author":"Camarasa J. 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A"},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1107\/S0907444998003254","volume":"54","author":"Brunger A. T.","year":"1998","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley P.","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1107\/S0907444904011679","volume":"60","author":"Schuttelkopf A. W.","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0076-6879(97)77018-6","volume":"277","author":"Sheldrick G. M.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"Laskowski R. A.","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/protein\/8.2.127","volume":"8","author":"Wallace A. C.","year":"1995","journal-title":"Protein Eng."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"10875","DOI":"10.1021\/ja047557p","volume":"126","author":"Banerjee A. L.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-2697(03)00346-4","volume":"320","author":"Copeland R. A.","year":"2003","journal-title":"Anal. Biochem."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1023\/A:1012976615056","volume":"14","author":"Auld D. S.","year":"2001","journal-title":"Biometals"},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"835","DOI":"10.2174\/156802607780636771","volume":"7","author":"Winum J. Y.","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/prot.340040406","volume":"4","author":"Eriksson A. E.","year":"1988","journal-title":"Proteins"},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"11054","DOI":"10.1021\/bi00110a007","volume":"30","author":"Fierke C. A.","year":"1991","journal-title":"Biochemistry"},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"17320","DOI":"10.1016\/S0021-9258(19)47376-6","volume":"266","author":"Nair S. K.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"4496","DOI":"10.1021\/bi00068a004","volume":"32","author":"Krebs J. F.","year":"1993","journal-title":"Biochemistry"},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/S0021-9258(18)54025-4","volume":"268","author":"Krebs J. F.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/abio.1996.0069","volume":"234","author":"Wimalasena K.","year":"1996","journal-title":"Anal. Biochem."},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1357-2725(00)00076-5","volume":"33","author":"Moruno-Davila M. A.","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref92\/cit92","volume-title":"Biochemistry","author":"Berg J. M.","year":"2007","edition":"6"},{"key":"ref93\/cit93","volume-title":"Concepts in Biochemistry","author":"Boyer R. F.","year":"2006","edition":"3"},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1021\/bi00220a006","volume":"30","author":"Jewell D. A.","year":"1991","journal-title":"Biochemistry"},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1093-3263(97)00021-1","volume":"15","author":"Esnouf R. M.","year":"1997","journal-title":"J. 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