{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:47:57Z","timestamp":1790696877415,"version":"4.1.0"},"reference-count":47,"publisher":"American Chemical Society (ACS)","issue":"36","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2008,9,9]]},"DOI":"10.1021\/bi800677k","type":"journal-article","created":{"date-parts":[[2008,8,16]],"date-time":"2008-08-16T06:02:25Z","timestamp":1218866545000},"page":"9380-9393","source":"Crossref","is-referenced-by-count":45,"title":["Molecular Basis for the Structural Instability of Human DJ-1 Induced by the L166P Mutation Associated with Parkinson\u2019s Disease"],"prefix":"10.1021","volume":"47","author":[{"given":"Peter C.","family":"Anderson","sequence":"first","affiliation":[{"name":"Biomedical and Health Informatics Program and Department of Bioengineering, University of Washington, Box 355013, Seattle, Washington 98195-5013"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Daggett","sequence":"additional","affiliation":[{"name":"Biomedical and Health Informatics Program and Department of Bioengineering, University of Washington, Box 355013, Seattle, Washington 98195-5013"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,8,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrg1831","volume":"7","author":"Farrer M. J.","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"Spillantini M. G.","year":"1997","journal-title":"Nature"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","volume":"392","author":"Kitada T.","year":"1998","journal-title":"Nature"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/77060","volume":"25","author":"Shimura H.","year":"2000","journal-title":"Nat. Genet."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/26652","volume":"395","author":"Leroy E.","year":"1998","journal-title":"Nature"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","volume":"304","author":"Valente E. M.","year":"2004","journal-title":"Science"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.neuron.2004.11.005","volume":"44","author":"Zimprich A.","year":"2004","journal-title":"Neuron"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ng1884","volume":"38","author":"Ramirez A.","year":"2006","journal-title":"Nat. Genet."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/j.1742-4658.2008.06301.x","volume":"275","author":"Belin A. C.","year":"2008","journal-title":"FEBS J."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","volume":"299","author":"Bonifati V.","year":"2003","journal-title":"Science"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/bbrc.1997.6132","volume":"231","author":"Nagakubo D.","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref12\/cit12","first-page":"3328","volume":"7","author":"Le Naour F.","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/(SICI)1097-4644(19990301)72:3<435::AID-JCB12>3.0.CO;2-H","volume":"72","author":"Hod Y.","year":"1999","journal-title":"J. Cell. Biochem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ccr.2005.02.010","volume":"7","author":"Kim R. H.","year":"2005","journal-title":"Cancer Cell"},{"key":"ref15\/cit15","first-page":"247","volume":"1","author":"Niki T.","year":"2003","journal-title":"Mol. Cancer Res."},{"key":"ref16\/cit16","first-page":"641","volume":"26","author":"Shinbo Y.","year":"2005","journal-title":"Int. J. Oncol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"37556","DOI":"10.1074\/jbc.M101730200","volume":"276","author":"Takahashi K.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/hmg\/ddi134","volume":"14","author":"Xu J.","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"14807","DOI":"10.1073\/pnas.0703219104","volume":"104","author":"Andres-Mateos E.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.1074\/jbc.M311017200","volume":"279","author":"Olzmann J. A.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"44552","DOI":"10.1074\/jbc.M304517200","volume":"278","author":"Lee S.-J.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1073\/pnas.0308089100","volume":"101","author":"Wilson M. A.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1371\/journal.pbio.0020362","volume":"2","author":"Shendelman S.","year":"2004","journal-title":"PLoS Biol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jmb.2005.12.030","volume":"356","author":"Zhou W.","year":"2006","journal-title":"J. Mol. Biol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"31380","DOI":"10.1074\/jbc.M305878200","volume":"278","author":"Honbou K.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"31372","DOI":"10.1074\/jbc.M304221200","volume":"278","author":"Tao X.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"9256","DOI":"10.1073\/pnas.1133288100","volume":"100","author":"Wilson M. A.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/1097-0134(20010201)42:2<230::AID-PROT100>3.0.CO;2-J","volume":"42","author":"Horvath M. M.","year":"2001","journal-title":"Proteins"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bbrc.2004.03.110","volume":"317","author":"Kinumi T.","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1074\/jbc.M309204200","volume":"279","author":"Goerner K.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1110\/ps.073411608","volume":"17","author":"Malgieri G.","year":"2008","journal-title":"Protein Sci."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"36588","DOI":"10.1074\/jbc.M304272200","volume":"278","author":"Miller D. W.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.mcn.2004.06.014","volume":"27","author":"Baulac S.","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1093\/hmg\/ddg304","volume":"12","author":"Macedo M. G.","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"ref35\/cit35","volume-title":"ENCAD","author":"Levitt M.","year":"1990"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0010-4655(95)00049-L","volume":"91","author":"Levitt M.","year":"1995","journal-title":"Comput. Phys. Commun."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1021\/jp964020s","volume":"101","author":"Levitt M.","year":"1997","journal-title":"J. Phys. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/je60032a018","volume":"12","author":"Kell G. S.","year":"1967","journal-title":"J. Chem. Eng. Data"},{"key":"ref39\/cit39","volume-title":"in lucem Molecular Mechanics","author":"Beck D. A. C.","year":"2000"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ymeth.2004.03.008","volume":"34","author":"Beck D. A. C.","year":"2004","journal-title":"Methods"},{"key":"ref41\/cit41","unstructured":"Hubbard, S. J., and Thornton, J. M.(1993) NACCESS Computer Program, Department of Biochemistry and Molecular Biology,University College,London."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1002\/bip.360221211","volume":"22","author":"Kabsch W.","year":"1983","journal-title":"Biopolymers"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"Pettersen E. F.","year":"2004","journal-title":"J. Comput. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"24905","DOI":"10.1074\/jbc.M701013200","volume":"282","author":"Herrera F.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1110\/ps.073096508","volume":"17","author":"Salisbury F. R.","year":"2008","journal-title":"Protein Sci."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/sj.cdd.4401704","volume":"13","author":"Shinbo Y.","year":"2006","journal-title":"Cell Death Differ."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","volume":"157","author":"Kyte J.","year":"1982","journal-title":"J. Mol. Biol."}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi800677k","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T01:01:38Z","timestamp":1679619698000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi800677k"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,16]]},"references-count":47,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2008,9,9]]}},"alternative-id":["10.1021\/bi800677k"],"URL":"https:\/\/doi.org\/10.1021\/bi800677k","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,16]]}}}