{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:02:42Z","timestamp":1788498162748,"version":"build-2803163510"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"48","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2008,12,2]]},"DOI":"10.1021\/bi801427c","type":"journal-article","created":{"date-parts":[[2008,11,7]],"date-time":"2008-11-07T09:02:20Z","timestamp":1226048540000},"page":"12680-12688","source":"Crossref","is-referenced-by-count":142,"title":["A Single Mutation in the Nonamyloidogenic Region of Islet Amyloid Polypeptide Greatly Reduces Toxicity"],"prefix":"10.1021","volume":"47","author":[{"given":"Jeffrey R.","family":"Brender","sequence":"first","affiliation":[{"name":"Departments of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Hartman","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendra R.","family":"Reid","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayyalusamy","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Departments of Chemistry and Biophysics, University of Michigan, Ann Arbor, Michigan 48109-1055"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,11,7]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00125-003-1304-4","volume":"47","author":"Clark A.","year":"2004","journal-title":"Diabetologia"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biocel.2005.12.009","volume":"38","author":"Hoppener J. W. M.","year":"2006","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref3\/cit3","first-page":"89","volume-title":"Neurobiology of Alzheimer\u2019s Disease","author":"Lorenzo A.","year":"1996"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/ilar.47.3.225","volume":"47","author":"Matveyenko A. V.","year":"2006","journal-title":"ILAR J."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1210\/er.2007-0037","volume":"29","author":"Haataja L.","year":"2008","journal-title":"Endocr. Rev."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s001250051175","volume":"42","author":"Hoppener J. W. M.","year":"1999","journal-title":"Diabetologia"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2337\/diabetes.47.5.743","volume":"47","author":"Soeller W. C.","year":"1998","journal-title":"Diabetes"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.2337\/db05-1672","volume":"55","author":"Matveyenko A. V.","year":"2006","journal-title":"Diabetes"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"E1656","DOI":"10.1152\/ajpendo.00318.2007","volume":"293","author":"Huang C. J.","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"7283","DOI":"10.1073\/pnas.93.14.7283","volume":"93","author":"Janson J.","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.2337\/diabetes.52.9.2304","volume":"52","author":"Butler A. E.","year":"2003","journal-title":"Diabetes"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.2337\/diabetes.54.7.2235","volume":"54","author":"Hull R. L.","year":"2005","journal-title":"Diabetes"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00006676-199510000-00014","volume":"11","author":"Tasaka Y.","year":"1995","journal-title":"Pancreas"},{"key":"ref14\/cit14","first-page":"801","volume":"35","author":"Bell E. T.","year":"1959","journal-title":"Am. J. Pathol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"17294","DOI":"10.1074\/jbc.M500997200","volume":"280","author":"Demuro A.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2337\/diabetes.48.3.491","volume":"48","author":"Janson J.","year":"1999","journal-title":"Diabetes"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1111\/j.1742-4658.2006.05367.x","volume":"273","author":"Konarkowska B.","year":"2006","journal-title":"FEBS J."},{"key":"ref18\/cit18","first-page":"E1317\u2212E1324","volume":"291","author":"Meier J. J.","year":"2006","journal-title":"Am. J. Physiol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2337\/diabetes.52.7.1701","volume":"52","author":"Ritzel R. A.","year":"2003","journal-title":"Diabetes"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"11338","DOI":"10.1021\/bi020314u","volume":"41","author":"Anguiano M.","year":"2002","journal-title":"Biochemistry"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.2337\/db06-1579","volume":"56","author":"Lin C. Y.","year":"2007","journal-title":"Diabetes"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"10427","DOI":"10.1073\/pnas.0502066102","volume":"102","author":"Quist A.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref23\/cit23a","doi-asserted-by":"crossref","first-page":"10971","DOI":"10.1021\/bi034889i","volume":"42","author":"Porat Y.","year":"2003","journal-title":"Biochemistry"},{"key":"ref23\/cit23b","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/j.bbamem.2007.07.001","volume":"1768","author":"Brender J. R.","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1529\/biophysj.107.117168","volume":"94","author":"Powers E. T.","year":"2008","journal-title":"Biophys. J."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"6424","DOI":"10.1021\/ja710484d","volume":"130","author":"Brender J. R.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"421287","DOI":"10.1155\/2008\/421287","author":"Khemtemourian L.","year":"2008","journal-title":"Exp. Diabetes Res."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"10311","DOI":"10.1074\/jbc.M608207200","volume":"282","author":"Necula M.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s12017-007-0003-6","volume":"9","author":"Yoshiike Y.","year":"2007","journal-title":"Neuromol. Med."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/j.1460-2075.1990.tb08079.x","volume":"9","author":"Pralong W. F.","year":"1990","journal-title":"EMBO J."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.bbamem.2006.07.001","volume":"1758","author":"Bechinger B.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0005-2736(99)00200-X","volume":"1462","author":"Shai Y.","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.bbamem.2007.11.008","volume":"1778","author":"Hoskin D. W.","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"9496","DOI":"10.1021\/bi060579z","volume":"45","author":"Knight J. D.","year":"2006","journal-title":"Biochemistry"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/000456329403100209","volume":"31","author":"Vanhulst K. L.","year":"1994","journal-title":"Ann. Clin. Biochem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1194\/jlr.R800007-JLR200","volume":"49","author":"Ariga T.","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0698-730","volume":"4","author":"Lee S. J.","year":"1998","journal-title":"Nat. Med."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1006\/jmbi.2001.4593","volume":"308","author":"Jaikaran E.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"16284","DOI":"10.1021\/bi051432v","volume":"44","author":"Abedini A.","year":"2005","journal-title":"Biochemistry"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"12689","DOI":"10.1021\/bi8014357","volume":"47","author":"Nanga R. P. R.","year":"2008","journal-title":"Biochemistry"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"14077","DOI":"10.1074\/jbc.275.19.14077","volume":"275","author":"Kawahara M.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0006-8993(95)00148-J","volume":"676","author":"Mattson M. P.","year":"1995","journal-title":"Brain Res."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.2337\/db07-0178","volume":"56","author":"Casas S.","year":"2007","journal-title":"Diabetes"},{"key":"ref43\/cit43","author":"Casas S.","year":"2008","journal-title":"Diabetologia"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1006\/jmbi.1998.2346","volume":"285","author":"Ladokhin A. S.","year":"1999","journal-title":"J. Mol. Biol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"12113","DOI":"10.1021\/bi050840w","volume":"44","author":"Jayasinghe S. A.","year":"2005","journal-title":"Biochemistry"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"10204","DOI":"10.1002\/chem.200700576","volume":"13","author":"Pappalardo G.","year":"2007","journal-title":"Chem.-Eur. J."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1039\/b106227c","volume":"25","author":"Grasso D.","year":"2001","journal-title":"New J. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1021\/bi036284s","volume":"43","author":"Henzler-Wildman K. A.","year":"2004","journal-title":"Biochemistry"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0304-4157(86)90004-3","volume":"864","author":"McElhaney R. N.","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/S0006-3495(03)75047-4","volume":"84","author":"Ivanova V. P.","year":"2003","journal-title":"Biophys. J."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"11023","DOI":"10.1021\/ja802210u","volume":"130","author":"Ramamoorthy A.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jmb.2004.06.086","volume":"341","author":"Knight J. D.","year":"2004","journal-title":"J. Mol. Biol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"4679","DOI":"10.1002\/anie.200705372","volume":"47","author":"Mishra R.","year":"2008","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/S0006-3495(00)76673-2","volume":"78","author":"Heimburg T.","year":"2000","journal-title":"Biophys. J."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1021\/jp0762020","volume":"112","author":"Sun X. Q.","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"9769","DOI":"10.1021\/la7014868","volume":"23","author":"Brasseur R.","year":"2007","journal-title":"Langmuir"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bpc.2006.05.008","volume":"126","author":"Epand R. M.","year":"2007","journal-title":"Biophys. Chem."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.bbamem.2006.01.018","volume":"1758","author":"Epand R. F.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0022-2836(02)01377-3","volume":"326","author":"Green J.","year":"2003","journal-title":"J. Mol. Biol."}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi801427c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T15:06:13Z","timestamp":1738508773000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi801427c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,7]]},"references-count":60,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2008,12,2]]}},"alternative-id":["10.1021\/bi801427c"],"URL":"https:\/\/doi.org\/10.1021\/bi801427c","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,7]]}}}