{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T03:12:25Z","timestamp":1767928345129,"version":"3.49.0"},"reference-count":53,"publisher":"American Chemical Society (ACS)","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2009,7,7]]},"DOI":"10.1021\/bi9002315","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T19:18:42Z","timestamp":1243883922000},"page":"6166-6174","source":"Crossref","is-referenced-by-count":53,"title":["High-Resolution Crystal Structure of the Snake Venom Metalloproteinase BaP1 Complexed with a Peptidomimetic: Insight into Inhibitor Binding"],"prefix":"10.1021","volume":"48","author":[{"given":"Torsten","family":"Lingott","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t, Stefan-Meier-Strasse 19, 79104 Freiburg im Breisgau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Schleberger","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t, Stefan-Meier-Strasse 19, 79104 Freiburg im Breisgau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Clodomiro Picado Institute, Faculty of Microbiology, University of Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmgard","family":"Merfort","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology and Biotechnology, Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universit\u00e4t, Stefan-Meier-Strasse 19, 79104 Freiburg im Breisgau, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2009,6,15]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0076-6879(95)48023-4","volume":"248","author":"Bjarnason J. B.","year":"1995","journal-title":"Methods Enzymol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0014-5793(93)80312-I","volume":"331","author":"Bode W.","year":"1993","journal-title":"FEBS Lett."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1385\/MB:24:2:157","volume":"24","author":"Gomis-Ruth F. X.","year":"2003","journal-title":"Mol. Biotechnol."},{"key":"ref4\/cit4","first-page":"328","volume":"142","author":"Ramos O. H. P.","year":"2006","journal-title":"Comp. Biochem. Phys., Part C: Pharmacol., Toxicol. Endocrinol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/pro.5560040502","volume":"4","author":"Stocker W.","year":"1995","journal-title":"Protein Sci."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"15353","DOI":"10.1074\/jbc.R800069200","volume":"284","author":"Gomis-Ruth F. X.","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1002\/j.1460-2075.1993.tb06099.x","volume":"12","author":"Gomis-Ruth F. X.","year":"1993","journal-title":"EMBO J."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ncprheum0797","volume":"4","author":"Moss M. L.","year":"2008","journal-title":"Nat. Clin. Pr. Rheumatol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.semcdb.2008.07.009","volume":"20","author":"Takeda S.","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"10783","DOI":"10.1073\/pnas.90.22.10783","volume":"90","author":"Wolfsberg T. G.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1101\/gad.1039703","volume":"17","author":"Seals D. F.","year":"2003","journal-title":"Genes Dev."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/j.1432-0436.2007.00198.x","volume":"75","author":"Kenny P. A.","year":"2007","journal-title":"Differentiation"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ceb.2003.08.001","volume":"15","author":"White J. M.","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref14\/cit14","volume-title":"Rabies and envenomings: A neglected public health issue","year":"2007"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0041-0101(98)00145-7","volume":"36","author":"Guti\u00e9rrez J. M.","year":"1998","journal-title":"Toxicon"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","volume":"82","author":"Guti\u00e9rrez J. M.","year":"2000","journal-title":"Biochimie"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0163-7258(94)90049-3","volume":"62","author":"Bjarnason J. B.","year":"1994","journal-title":"Pharmacol. Ther."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0041-0101(94)00138-X","volume":"33","author":"Guti\u00e9rrez J. M.","year":"1995","journal-title":"Toxicon"},{"key":"ref19\/cit19","first-page":"245","volume":"79","author":"Rucavado A.","year":"1998","journal-title":"Int. J. Exp. Pathol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1111\/j.1742-4658.2008.06466.x","volume":"275","author":"Fox J. W.","year":"2008","journal-title":"FEBS J."},{"key":"ref21\/cit21","first-page":"646","volume-title":"Clinical Toxicology of Animal Venoms and Poisons","author":"Guti\u00e9rrez J. M.","year":"1995"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.toxicon.2006.01.009","volume":"47","author":"Fernandes C. M.","year":"2006","journal-title":"Toxicon"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1006\/exmp.1995.1042","volume":"63","author":"Rucavado A.","year":"1995","journal-title":"Exp. Mol. Pathol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1110\/ps.03102403","volume":"12","author":"Watanabe L.","year":"2003","journal-title":"Protein Sci."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1006\/jmbi.1998.2110","volume":"283","author":"Gong W. M.","year":"1998","journal-title":"J. Mol. Biol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.toxicon.2004.07.005","volume":"44","author":"Ramos O. H. P.","year":"2004","journal-title":"Toxicon"},{"key":"ref27\/cit27","first-page":"205","volume":"129","author":"Stocker K.","year":"1999","journal-title":"Schweiz. Med. Wochenschr."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1007\/s00018-006-6315-0","volume":"63","author":"Koh D. C. I.","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1021\/bi00798a004","volume":"10","author":"Ondetti M. A.","year":"1971","journal-title":"Biochemistry"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1073\/pnas.93.7.2749","volume":"93","author":"Botos I.","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0014-5793(97)01401-4","volume":"418","author":"Cirilli M.","year":"1997","journal-title":"FEBS Lett."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/pro.5560070207","volume":"7","author":"Gomis-Ruth F. X.","year":"1998","journal-title":"Protein Sci."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1046\/j.1432-1033.2002.02982.x","volume":"269","author":"Huang K. F.","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jsb.2005.09.006","volume":"152","author":"Lou Z.","year":"2005","journal-title":"J. Struct. Biol."},{"key":"ref35\/cit35","first-page":"1834","volume":"55","author":"Zhu X. Y.","year":"1999","journal-title":"Acta Crystallogr."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/cmdc.200600204","volume":"2","author":"Jacobsen F. E.","year":"2007","journal-title":"Chem. Med. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1006\/jmbi.1994.1392","volume":"239","author":"Gomis-Ruth F. X.","year":"1994","journal-title":"J. Mol. Biol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1107\/S0108767302005676","volume":"58","author":"Huang K. F.","year":"2002","journal-title":"Acta Crystallogr."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/oxfordjournals.jbchem.a021215","volume":"119","author":"Kumasaka T.","year":"1996","journal-title":"J. Biochem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1073\/pnas.91.18.8447","volume":"91","author":"Zhang D. C.","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli U. K.","year":"1970","journal-title":"Nature"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2004.09.031","volume":"324","author":"Wang W. J.","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1107\/S0021889888007903","volume":"21","author":"Kabsch W.","year":"1988","journal-title":"J. Appl. Crystallogr."},{"key":"ref44\/cit44","first-page":"240","volume":"53","author":"Murshudov G. N.","year":"1997","journal-title":"Acta Crystallogr."},{"key":"ref45\/cit45","first-page":"2126","volume":"60","author":"Emsley P.","year":"2004","journal-title":"Acta Crystallogr."},{"key":"ref46\/cit46","first-page":"1355","volume":"60","author":"Schuttelkopf A. W.","year":"2004","journal-title":"Acta Crystallogr."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0076-6879(97)77016-2","volume":"277","author":"Lamzin V. S.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1107\/S0021889803006721","volume":"36","author":"Fenn T. D.","year":"2003","journal-title":"J. Appl. Crystallogr."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","volume":"24","author":"Kraulis P. J.","year":"1991","journal-title":"J. Appl. Crystallogr."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/pro.5560070805","volume":"7","author":"Alberts I. L.","year":"1998","journal-title":"Protein Sci."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.sab.2007.10.009","volume":"62","author":"Zhao W.","year":"2007","journal-title":"Spectrochim. Acta, Part B"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/bip.20070","volume":"74","author":"Xu X. L.","year":"2004","journal-title":"Biopolymers"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","volume":"50","author":"Lovell S. C.","year":"2003","journal-title":"Proteins"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi9002315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T14:26:46Z","timestamp":1678285606000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi9002315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,15]]},"references-count":53,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2009,7,7]]}},"alternative-id":["10.1021\/bi9002315"],"URL":"https:\/\/doi.org\/10.1021\/bi9002315","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,15]]}}}