{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:36:35Z","timestamp":1790728595573,"version":"4.1.0"},"reference-count":58,"publisher":"American Chemical Society (ACS)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2010,2,23]]},"DOI":"10.1021\/bi901753h","type":"journal-article","created":{"date-parts":[[2010,1,25]],"date-time":"2010-01-25T19:28:37Z","timestamp":1264447717000},"page":"1533-1540","source":"Crossref","is-referenced-by-count":27,"title":["The Clustering and Spatial Arrangement of \u03b2-Sheet Sequence, but Not Order, Govern \u03b1-Synuclein Fibrillogenesis"],"prefix":"10.1021","volume":"49","author":[{"given":"Jae-Eun","family":"Suk","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, California 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya Bekshe","family":"Lokappa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, California 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias S.","family":"Ulmer","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, Los Angeles, California 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2010,2,2]]},"reference":[{"key":"ref1\/cit1","first-page":"146","volume":"64","author":"Alzheimer A.","year":"1907","journal-title":"Allg. Z. Psychiatr. Ihre Grenzgeb."},{"key":"ref2\/cit2","first-page":"920","volume-title":"Pathologische Anatomie. Handbuch der Neurologie","author":"Lewy F. H.","year":"1912"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/35081564","volume":"2","author":"Goedert M.","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","author":"Chiti F.","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2006.09.026","volume":"52","author":"Lee V. M. Y.","year":"2006","journal-title":"Neuron"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.neurobiolaging.2005.04.017","volume":"27","author":"Glabe C. G.","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1017\/S0033583506004422","volume":"39","author":"Lashuel H. A.","year":"2006","journal-title":"Q. Rev. Biophys."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0033583506004173","volume":"39","author":"Tycko R.","year":"2006","journal-title":"Q. Rev. Biophys."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11084-009-9165-6","volume":"39","author":"Maury C. P. J.","year":"2009","journal-title":"Origins Life Evol. Biosphere"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1073\/pnas.0509567103","volume":"103","author":"Shults C. W.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1074\/jbc.273.16.9443","volume":"273","author":"Davidson W. S.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"26292","DOI":"10.1074\/jbc.273.41.26292","volume":"273","author":"Jensen P. H.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","volume":"25","author":"Abeliovich A.","year":"2000","journal-title":"Neuron"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"24970","DOI":"10.1074\/jbc.M700368200","volume":"282","author":"Chen M.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"8637","DOI":"10.1073\/pnas.0712179105","volume":"105","author":"Vilar M.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"13322","DOI":"10.1021\/bi7014053","volume":"46","author":"Qin Z.","year":"2007","journal-title":"Biochemistry"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"15871","DOI":"10.1073\/pnas.0506109102","volume":"102","author":"Heise H.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/1097-0134(20001115)41:3<415::AID-PROT130>3.0.CO;2-7","volume":"41","author":"Uversky V. N.","year":"2000","journal-title":"Proteins"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1073\/pnas.90.23.11282","volume":"90","author":"Ueda K.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/1074-5521(95)90071-3","volume":"2","author":"Han H. Y.","year":"1995","journal-title":"Chem. Biol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1021\/bi020429y","volume":"42","author":"Kessler J. C.","year":"2003","journal-title":"Biochemistry"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jmb.2007.09.039","volume":"374","author":"Zibaee S.","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1021\/bi027363r","volume":"42","author":"Murray I. V. J.","year":"2003","journal-title":"Biochemistry"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1073\/pnas.0407146102","volume":"102","author":"Bertoncini C. W.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.bbadis.2008.07.004","volume":"1782","author":"Ulrih N. P.","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature01891","volume":"424","author":"Chiti F.","year":"2003","journal-title":"Nature"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1073\/pnas.0511295103","volume":"103","author":"Thompson M. J.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1000333","volume":"5","author":"Bryan A. W.","year":"2009","journal-title":"PLoS Comput. Biol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1110\/ps.062624507","volume":"16","author":"Zibaee S.","year":"2007","journal-title":"Protein Sci."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1039\/b706784b","volume":"37","author":"Tartaglia G. G.","year":"2008","journal-title":"Chem. Soc. Rev."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/nbt1012","volume":"22","author":"Fernandez-Escamilla A. M.","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jmb.2009.05.058","volume":"390","author":"Rao J. N.","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1093\/nar\/30.10.e43","volume":"30","author":"Hoover D. M.","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1021\/bi8002378","volume":"47","author":"Rao J. N.","year":"2008","journal-title":"Biochemistry"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0003-2697(89)90046-8","volume":"177","author":"Naiki H.","year":"1989","journal-title":"Anal. Biochem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jsb.2005.06.006","volume":"151","author":"Khurana R.","year":"2005","journal-title":"J. Struct. Biol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"19509","DOI":"10.1074\/jbc.274.28.19509","volume":"274","author":"Wood S. J.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"11970","DOI":"10.1074\/jbc.M109541200","volume":"277","author":"Uversky V. N.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/bi020604a","volume":"42","author":"Park J. Y.","year":"2003","journal-title":"Biochemistry"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1021\/bi0600749","volume":"45","author":"Masuda M.","year":"2006","journal-title":"Biochemistry"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1006\/jmbi.2001.4538","volume":"307","author":"Eliezer D.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"17968","DOI":"10.1021\/ja055538p","volume":"127","author":"Bernado P.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1021\/bi062068i","volume":"46","author":"Jiang C. T.","year":"2007","journal-title":"Biochemistry"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0076-6879(04)83013-1","volume-title":"Numerical Computer Methods, Part D","author":"Sreerama N.","year":"2004"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jmb.2008.05.026","volume":"380","author":"Heise H.","year":"2008","journal-title":"J. Mol. Biol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-2836(02)00775-1","volume":"322","author":"Hoyer W.","year":"2002","journal-title":"J. Mol. Biol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"10737","DOI":"10.1074\/jbc.M010907200","volume":"276","author":"Uversky V. N.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"36436","DOI":"10.1074\/jbc.M005698200","volume":"275","author":"Huang T. H. J.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"9096","DOI":"10.1021\/bi048778a","volume":"44","author":"Yamin G.","year":"2005","journal-title":"Biochemistry"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"12916","DOI":"10.1073\/pnas.0402634101","volume":"101","author":"Hwang W.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1074\/jbc.M008919200","volume":"276","author":"Giasson B. I.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"9427","DOI":"10.1021\/bi900539p","volume":"48","author":"Waxman E. A.","year":"2009","journal-title":"Biochemistry"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1021\/bi0356707","volume":"43","author":"Lee E. N.","year":"2004","journal-title":"Biochemistry"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.18388\/abp.2003_3645","volume":"50","author":"Stopa B.","year":"2003","journal-title":"Acta Biochim. Pol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"12825","DOI":"10.1073\/pnas.0506136102","volume":"102","author":"Ross E. D.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/bioinformatics\/btg430","volume":"20","author":"Clamp M.","year":"2004","journal-title":"Bioinformatics"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","volume":"157","author":"Kyte J.","year":"1982","journal-title":"J. Mol. Biol."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.bi.47.070178.001343","volume":"47","author":"Chou P. Y.","year":"1978","journal-title":"Annu. Rev. Biochem."}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi901753h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:16:31Z","timestamp":1680567391000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi901753h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,2]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010,2,23]]}},"alternative-id":["10.1021\/bi901753h"],"URL":"https:\/\/doi.org\/10.1021\/bi901753h","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,2]]}}}