{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:53:26Z","timestamp":1762865606131},"reference-count":39,"publisher":"American Chemical Society (ACS)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2010,3,9]]},"DOI":"10.1021\/bi901974a","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T00:51:40Z","timestamp":1264726300000},"page":"1822-1832","source":"Crossref","is-referenced-by-count":30,"title":["Mechanism and Specificity of a Symmetrical Benzimidazolephenylcarboxamide Helicase Inhibitor"],"prefix":"10.1021","volume":"49","author":[{"given":"Craig A.","family":"Belon","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji D.","family":"High","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tse-I","family":"Lin","sequence":"additional","affiliation":[{"name":"HCV Research, Tibotec, Mechelen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Pauwels","sequence":"additional","affiliation":[{"name":"HCV Research, Tibotec, Mechelen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Frick","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2010,2,9]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nrd1853","volume":"4","author":"Kwong A. D.","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.2174\/138161206776361147","volume":"12","author":"Frick D. N.","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"ref3\/cit3","first-page":"1","volume":"9","author":"Frick D. N.","year":"2007","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2217\/fvl.09.7","volume":"4","author":"Belon C. A.","year":"2009","journal-title":"Future Virol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0960-894X(01)00263-3","volume":"11","author":"Phoon C. W.","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1074\/jbc.M310630200","volume":"279","author":"Frick D. N.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"34913","DOI":"10.1074\/jbc.M707165200","volume":"282","author":"Beran R. K.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1128\/JVI.01849-08","volume":"83","author":"Beran R. K.","year":"2009","journal-title":"J. Virol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0969-2126(98)00010-0","volume":"6","author":"Kim J. L.","year":"1998","journal-title":"Structure"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S0969-2126(00)80025-8","volume":"7","author":"Yao N.","year":"1999","journal-title":"Struct. Folding Des."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1099\/vir.0.80401-0","volume":"85","author":"Simmonds P.","year":"2004","journal-title":"J. Gen. Virol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa020047","volume":"347","author":"Fried M. W.","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"7352","DOI":"10.1128\/JVI.78.14.7352-7359.2004","volume":"78","author":"Thibeault D.","year":"2004","journal-title":"J. Virol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1128\/JVI.01543-06","volume":"81","author":"Pauwels F.","year":"2007","journal-title":"J. Virol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1038\/emboj.2008.232","volume":"27","author":"Luo D.","year":"2008","journal-title":"EMBO J."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1128\/JVI.01788-07","volume":"82","author":"Luo D.","year":"2008","journal-title":"J. Virol."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2004.09.029","volume":"119","author":"Yedavalli V. S.","year":"2004","journal-title":"Cell"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1021\/jm800332m","volume":"51","author":"Yedavalli V. S.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1128\/JVI.77.7.3950-3961.2003","volume":"77","author":"Lam A. M.","year":"2003","journal-title":"J. Virol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1128\/JVI.01700-07","volume":"82","author":"Neumann-Haefelin C.","year":"2008","journal-title":"J. Virol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jmb.2006.10.023","volume":"365","author":"Frick D. N.","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jmb.2009.03.059","volume":"388","author":"Belon C. A.","year":"2009","journal-title":"J. Mol. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.1114016","volume":"309","author":"Lindenbach B. D.","year":"2005","journal-title":"Science"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"10278","DOI":"10.1128\/JVI.79.16.10278-10288.2005","volume":"79","author":"Xu T.","year":"2005","journal-title":"J. Virol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/prot.21812","volume":"70","author":"Speroni S.","year":"2008","journal-title":"Proteins"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0003-2697(79)90115-5","volume":"100","author":"Lanzetta P. A.","year":"1979","journal-title":"Anal. Biochem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2144\/000112834","volume":"45","author":"Belon C. A.","year":"2008","journal-title":"BioTechniques"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"24449","DOI":"10.1074\/jbc.271.40.24449","volume":"271","author":"Preugschat F.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"44514","DOI":"10.1074\/jbc.M306444200","volume":"278","author":"Lam A. M.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1093\/nar\/gkh743","volume":"32","author":"Lam A. M.","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1021\/jm801608u","volume":"52","author":"Manfroni G.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1515\/BC.2009.040","volume":"390","author":"Krawczyk M.","year":"2009","journal-title":"Biol. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1021\/jm8011905","volume":"52","author":"Chen C. S.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1128\/AAC.00961-07","volume":"52","author":"Gozdek A.","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1074\/jbc.M512100200","volume":"281","author":"Mackintosh S. G.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Cheng Y.","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1074\/jbc.M805540200","volume":"284","author":"Jennings T. A.","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/S0006-2952(97)00663-1","volume":"55","author":"Copeland R. A.","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1021\/ja010041a","volume":"123","author":"Boger D. L.","year":"2001","journal-title":"J. Am. Chem. Soc."}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi901974a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T03:56:02Z","timestamp":1680666962000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi901974a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,9]]},"references-count":39,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2010,3,9]]}},"alternative-id":["10.1021\/bi901974a"],"URL":"https:\/\/doi.org\/10.1021\/bi901974a","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,9]]}}}