{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:55:28Z","timestamp":1791197728823,"version":"4.1.0"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[1996,1,1]]},"DOI":"10.1021\/bi9515127","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:13:40Z","timestamp":1027660420000},"page":"243-250","source":"Crossref","is-referenced-by-count":323,"title":["Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol<sup>,<\/sup>"],"prefix":"10.1021","volume":"35","author":[{"given":"Ernst","family":"ter Haar","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health, Department of Pharmaceutical Sciences, and the University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Department of Pharmaceutical Sciences, and the University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Hamel","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Department of Pharmaceutical Sciences, and the University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chii M.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Department of Pharmaceutical Sciences, and the University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross E.","family":"Longley","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Department of Pharmaceutical Sciences, and the University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarath P.","family":"Gunasekera","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Department of Pharmaceutical Sciences, and the University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert S.","family":"Rosenkranz","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Department of Pharmaceutical Sciences, and the University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Billy W.","family":"Day","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, Department of Pharmaceutical Sciences, and the University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15238, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, and Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[1996,1,9]]},"reference":[{"key":"atypb1\/atypb2","volume-title":"Mol. Pharmacol. 44, 757\u2212766","author":"Bai R.","year":"1993"},{"key":"atypb3\/atypb4","doi-asserted-by":"crossref","DOI":"10.1016\/S0960-894X(01)81233-6","volume":"3","author":"Beutler J. A.","year":"1993","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"atypb5\/atypb6","volume-title":"Cancer Res. 55, 2325\u22122333","author":"Bollag D. M.","year":"1995"},{"key":"atypb7\/atypb8","doi-asserted-by":"crossref","DOI":"10.1021\/ja00088a063","volume":"116","author":"Chaudhary A. G.","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"atypb9\/atypb10","doi-asserted-by":"crossref","DOI":"10.1021\/jo00074a005","volume":"58","author":"Clark D. L.","year":"1993","journal-title":"J. Org. Chem."},{"key":"atypb11\/atypb12","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.105.6.2847","volume":"105","author":"Collins C. A.","year":"1987","journal-title":"J. Cell Biol."},{"key":"atypb13\/atypb14","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 78, 5608\u22125612","author":"De Brabander M.","year":"1981"},{"key":"atypb15\/atypb16","volume-title":"Biochemistry 34, 2203\u22122211","author":"Derry W. B.","year":"1995"},{"key":"atypb17\/atypb18","volume":"34","author":"Evans P. L.","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"atypb19\/atypb20","volume":"34","author":"Golec J. M. C.","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"atypb21\/atypb22","volume":"34","author":"Golec J. M. C.","year":"1993","journal-title":"Tetrahedron Lett."},{"key":"atypb23\/atypb24","volume-title":"Biochemistry 34, 3927\u22123934","author":"Grover S.","year":"1995"},{"key":"atypb25\/atypb26","volume":"55","author":"Gunasekera S. P.","year":"1990","journal-title":"J. Org. Chem."},{"key":"atypb27\/atypb28","author":"Hamel E.","year":"1996","journal-title":"Med. Res. Rev. (in press)."},{"key":"atypb29\/atypb30","volume-title":"Biochemistry 23, 4173\u22124184","author":"Hamel E.","year":"1984"},{"key":"atypb31\/atypb32","first-page":"71","volume":"1","author":"Hung D. T.","year":"1994","journal-title":"Chem. Biol."},{"key":"atypb33\/atypb34","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 90, 9552\u22129556","author":"Jordan M. A.","year":"1993"},{"key":"atypb35\/atypb36","doi-asserted-by":"crossref","DOI":"10.1021\/ci00009a013","volume":"32","author":"Klopman G.","year":"1992","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"atypb37\/atypb38","volume-title":"Cancer Chemother. Pharmacol. (in press)","author":"Lin C. M.","year":"1996"},{"key":"atypb39\/atypb40","volume-title":"Transplantation 52, 650\u2212656","author":"Longley R. E.","year":"1991"},{"key":"atypb41\/atypb42","volume-title":"Transplantation 52, 656\u2212661","author":"Longley R. E.","year":"1991"},{"key":"atypb43\/atypb44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1749-6632.1993.tb17145.x","volume":"696","author":"Longley R. E.","year":"1993","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"atypb45\/atypb46","doi-asserted-by":"crossref","DOI":"10.1021\/ja00079a066","volume":"115","author":"Nerenberg J. B.","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"atypb47\/atypb48","volume":"21","author":"Paterson I.","year":"1993","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"atypb49\/atypb50","volume-title":"Sem. Oncol. 19, 646\u2212662","author":"Rowinsky E. K.","year":"1992"},{"key":"atypb51\/atypb52","volume-title":"Nature 277, 665\u2212667","author":"Schiff P. B.","year":"1979"},{"key":"atypb53\/atypb54","first-page":"337","volume":"35","author":"Ter Haar E.","year":"1994","journal-title":"Proc. Am. Assoc. Cancer Res."},{"key":"atypb55\/atypb56","first-page":"352","volume":"36","author":"Ter Haar E.","year":"1995","journal-title":"Proc. Am. Assoc. Cancer Res."},{"key":"atypb57\/atypb58","volume":"35","author":"Yang G.","year":"1994","journal-title":"Tetrahedron Lett."},{"key":"atypb59\/atypb60","volume":"35","author":"Yang G.","year":"1994","journal-title":"Tetrahedron Lett."},{"key":"bi9515127b00002\/bi9515127b00002_1","volume-title":"fetal calf serum","author":"Abbreviations FCS"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi9515127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T23:08:50Z","timestamp":1704236930000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi9515127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1,1]]}},"alternative-id":["10.1021\/bi9515127"],"URL":"https:\/\/doi.org\/10.1021\/bi9515127","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,1,1]]}}}