{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:48:49Z","timestamp":1770716929589,"version":"3.49.0"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[1997,1,1]]},"DOI":"10.1021\/bi961848w","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:05:07Z","timestamp":1027659907000},"page":"156-163","source":"Crossref","is-referenced-by-count":18,"title":["A Novel Metalloprotease in Rat Brain Cleaves the Amyloid Precursor Protein of Alzheimer's Disease Generating Amyloidogenic Fragments"],"prefix":"10.1021","volume":"36","author":[{"given":"Su San","family":"Mok","sequence":"first","affiliation":[{"name":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia, The Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Victoria 3052, Australia, Peptide Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria 3181, Australia, and the Center for Molecular Biology, The University of Heidelberg, Heidelberg, D-6900 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Evin","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia, The Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Victoria 3052, Australia, Peptide Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria 3181, Australia, and the Center for Molecular Biology, The University of Heidelberg, Heidelberg, D-6900 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao-Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia, The Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Victoria 3052, Australia, Peptide Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria 3181, Australia, and the Center for Molecular Biology, The University of Heidelberg, Heidelberg, D-6900 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Ian","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia, The Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Victoria 3052, Australia, Peptide Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria 3181, Australia, and the Center for Molecular Biology, The University of Heidelberg, Heidelberg, D-6900 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Beyreuther","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia, The Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Victoria 3052, Australia, Peptide Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria 3181, Australia, and the Center for Molecular Biology, The University of Heidelberg, Heidelberg, D-6900 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia, The Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Victoria 3052, Australia, Peptide Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria 3181, Australia, and the Center for Molecular Biology, The University of Heidelberg, Heidelberg, D-6900 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David H.","family":"Small","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Melbourne, Parkville, Victoria 3052, Australia, The Mental Health Research Institute of Victoria, Royal Park Hospital, Parkville, Victoria 3052, Australia, Peptide Biology Laboratory, Baker Medical Research Institute, Prahran, Victoria 3181, Australia, and the Center for Molecular Biology, The University of Heidelberg, Heidelberg, D-6900 Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[1997,1,7]]},"reference":[{"key":"atypb1\/atypb2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(91)90905-B","volume":"551","author":"Allsop D.","year":"1991","journal-title":"Brain Res."},{"key":"atypb3\/atypb4","doi-asserted-by":"crossref","first-page":"11376","DOI":"10.1074\/jbc.271.19.11376","volume":"271","author":"Arribas J.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"atypb5\/atypb6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jnr.490290115","volume":"29","author":"Baskin F.","year":"1991","journal-title":"J. Neurosci. Res."},{"key":"atypb7\/atypb8","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1016\/S0021-9258(17)42055-2","volume":"269","author":"Boseman-Roberts S. B.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"atypb9\/atypb10","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1073\/pnas.90.5.2092","volume":"90","author":"Busciglio J.","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"atypb11\/atypb12","doi-asserted-by":"crossref","first-page":"6003","DOI":"10.1073\/pnas.87.15.6003","volume":"87","author":"Buxbaum J. D.","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"atypb13\/atypb14","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1073\/pnas.89.6.2252","volume":"89","author":"Caporaso G. L.","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"atypb15\/atypb16","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1523\/JNEUROSCI.14-05-03122.1994","volume":"14","author":"Caporaso G. L.","year":"1994","journal-title":"J. Neurosci."},{"key":"atypb17\/atypb18","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1046\/j.1471-4159.1995.65041431.x","volume":"65","author":"Checler F.","year":"1995","journal-title":"J. Neurochem."},{"key":"atypb19\/atypb20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/13506129409148622","volume":"1","author":"Cheung T. T.","year":"1994","journal-title":"Amyloid"},{"key":"atypb21\/atypb22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1042\/bj0600604","volume":"60","author":"De Duve C.","year":"1955","journal-title":"Biochem. J."},{"key":"atypb23\/atypb24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1083\/jcb.121.2.295","volume":"121","author":"De Strooper B.","year":"1993","journal-title":"J. Cell Biol."},{"key":"atypb25\/atypb26","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1002\/j.1460-2075.1995.tb00176.x","volume":"14","author":"De Strooper B.","year":"1995","journal-title":"EMBO J."},{"key":"atypb27\/atypb28","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.2111583","volume":"248","author":"Esch F. S.","year":"1990","journal-title":"Science"},{"key":"atypb29\/atypb30","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.1738846","volume":"255","author":"Estus S.","year":"1992","journal-title":"Science"},{"key":"atypb31\/atypb32","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/13506129409146118","volume":"1","author":"Evin G.","year":"1994","journal-title":"Amyloid"},{"key":"atypb33\/atypb34","doi-asserted-by":"crossref","first-page":"14185","DOI":"10.1021\/bi00043a024","volume":"34","author":"Evin G.","year":"1995","journal-title":"Biochemistry"},{"key":"atypb35\/atypb36","doi-asserted-by":"crossref","first-page":"8091","DOI":"10.1021\/bi00025a015","volume":"34","author":"Fuller S. J.","year":"1995","journal-title":"Biochemistry"},{"key":"atypb37\/atypb38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1471-4159.1992.tb09322.x","volume":"58","author":"Gandy S. E.","year":"1992","journal-title":"J. Neurochem."},{"key":"atypb39\/atypb40","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.1738847","volume":"255","author":"Golde T. E.","year":"1992","journal-title":"Science"},{"key":"atypb41\/atypb42","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/357500a0","volume":"357","author":"Haass C.","year":"1992","journal-title":"Nature"},{"key":"atypb43\/atypb44","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/359322a0","volume":"359","author":"Haass C.","year":"1992","journal-title":"Nature"},{"key":"atypb45\/atypb46","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1111\/j.1749-6632.1993.tb23037.x","volume":"695","author":"Haass C.","year":"1993","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"atypb47\/atypb48","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1073\/pnas.91.4.1564","volume":"91","author":"Haass C.","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"atypb49\/atypb50","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1172\/JCI103079","volume":"34","author":"Jacox R. F.","year":"1955","journal-title":"J. Clin. Invest."},{"key":"atypb51\/atypb52","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/325733a0","volume":"325","author":"Kang J.","year":"1987","journal-title":"Nature"},{"key":"atypb53\/atypb54","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0076-6879(74)31052-X","volume":"31","author":"Koenig H.","year":"1974","journal-title":"Methods Enzymol."},{"key":"atypb55\/atypb56","doi-asserted-by":"crossref","first-page":"17386","DOI":"10.1016\/S0021-9258(17)32449-3","volume":"269","author":"Koo E. H.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"atypb57\/atypb58","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/bj2950367","volume":"295","author":"Kuentzel S. L.","year":"1993","journal-title":"Biochem. J."},{"key":"atypb59\/atypb60","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli U. K.","year":"1970","journal-title":"Nature"},{"key":"atypb61\/atypb62","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0014-5793(95)01358-X","volume":"377","author":"LePage R. N.","year":"1995","journal-title":"FEBS Lett."},{"key":"atypb63\/atypb64","doi-asserted-by":"crossref","first-page":"14140","DOI":"10.1074\/jbc.270.23.14140","volume":"270","author":"Li Q. X.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"atypb65\/atypb66","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/0006-291X(91)91767-7","volume":"179","author":"Maruyama K.","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"atypb67\/atypb68","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/362839a0","volume":"362","author":"Miyazaki K.","year":"1993","journal-title":"Nature"},{"key":"atypb69\/atypb70","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/0006-291X(91)91691-5","volume":"179","author":"McDermott J. R.","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"atypb71\/atypb72","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/0006-291X(92)91689-N","volume":"185","author":"McDermott J. R.","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"atypb73\/atypb74","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1016\/S0021-9258(19)39590-0","volume":"265","author":"Oltersdorf T.","year":"1990","journal-title":"J. Biol. Chem."},{"key":"atypb75\/atypb76","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1021\/bi00167a025","volume":"33","author":"Papastoitsis G.","year":"1994","journal-title":"Biochemistry"},{"key":"atypb77\/atypb78","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0197-4580(91)90006-6","volume":"12","author":"Price J. L.","year":"1991","journal-title":"Neurobiol. Aging"},{"key":"atypb79\/atypb80","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0076-6879(78)57038-9","volume":"57","author":"Rosewell D. F.","year":"1978","journal-title":"Methods Enzymol."},{"key":"atypb81\/atypb82","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/jnr.490390211","volume":"39","author":"Ripellino J. A.","year":"1994","journal-title":"J. Neurosci. Res."},{"key":"atypb83\/atypb84","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/jnr.490330216","volume":"33","author":"Sambamurti K.","year":"1992","journal-title":"J. Neurosci. Res."},{"key":"atypb85\/atypb86","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/bbrc.1994.1667","volume":"201","author":"Sch\u00f6nlein C.","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"atypb87\/atypb88","volume-title":"S80\u2212#317.","author":"Seubert P.","year":"1992"},{"key":"atypb89\/atypb90","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/361260a0","volume":"361","author":"Seubert P.","year":"1993","journal-title":"Nature"},{"key":"atypb91\/atypb92","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1126\/science.1439760","volume":"258","author":"Shoji M.","year":"1992","journal-title":"Science"},{"key":"atypb93\/atypb94","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1523\/JNEUROSCI.16-03-00899.1996","volume":"16","author":"Simons M.","year":"1996","journal-title":"J. Neurosci."},{"key":"atypb95\/atypb96","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1073\/pnas.89.13.6075","volume":"89","author":"Sisodia S. S.","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"atypb97\/atypb98","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1126\/science.1691865","volume":"248","author":"Sisodia S. S.","year":"1990","journal-title":"Science"},{"key":"atypb99\/atypb100","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1016\/S0021-9258(17)41992-2","volume":"269","author":"Slunt H. H.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"atypb101\/atypb102","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0076-6879(90)82018-W","volume":"182","author":"Storrie B.","year":"1990","journal-title":"Methods Enzymol."},{"key":"atypb103\/atypb104","first-page":"100","volume":"1","author":"Sun X.","year":"1994","journal-title":"Int. J. Exp. Clin. Invest."},{"key":"atypb105\/atypb106","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1126\/science.8191290","volume":"264","author":"Suzuki N.","year":"1994","journal-title":"Science"},{"key":"atypb107\/atypb108","doi-asserted-by":"crossref","first-page":"6314","DOI":"10.1523\/JNEUROSCI.15-10-06314.1995","volume":"15","author":"Thinakaran G.","year":"1995","journal-title":"J. Neurosci."},{"key":"atypb109\/atypb110","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1074\/jbc.271.16.9390","volume":"271","author":"Thinakaran G.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"atypb111\/atypb112","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1046\/j.1471-4159.1995.64052140.x","volume":"64","author":"Vassilacopoulou D.","year":"1995","journal-title":"J. Neurochem."},{"key":"atypb113\/atypb114","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1042\/bst022014s","volume":"22","author":"Walsh D. M.","year":"1993","journal-title":"Biochem. Soc. Trans."},{"key":"atypb115\/atypb116","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0092-8674(89)90177-3","volume":"57","author":"Weidemann A.","year":"1989","journal-title":"Cell"},{"key":"atypb117\/atypb118","doi-asserted-by":"crossref","first-page":"23243","DOI":"10.1074\/jbc.270.40.23243","volume":"270","author":"Xu H.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi961848wb00001\/bi961848wb00001_1","volume-title":"Alzheimer's disease","author":"Abbreviations AD"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi961848w","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T17:08:03Z","timestamp":1678208883000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi961848w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1,1]]}},"alternative-id":["10.1021\/bi961848w"],"URL":"https:\/\/doi.org\/10.1021\/bi961848w","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,1,1]]}}}