{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:33:33Z","timestamp":1761057213068},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"23","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[1997,6,1]]},"DOI":"10.1021\/bi9702849","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:05:17Z","timestamp":1027659917000},"page":"6936-6940","source":"Crossref","is-referenced-by-count":35,"title":["Purification, Characterization, and Synthesis of an Inward-Rectifier K<sup>+<\/sup> Channel Inhibitor from Scorpion Venom"],"prefix":"10.1021","volume":"36","author":[{"given":"Zhe","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick","family":"MacKinnon","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[1997,6,10]]},"reference":[{"key":"bi9702849b00001\/bi9702849b00001_1","volume-title":"TINS Suppl., 1\u221229","author":"Adams M. E.","year":"1994"},{"key":"bi9702849b00002\/bi9702849b00002_1","volume-title":"Nature 371, 119\u2212122","author":"Jan L. Y.","year":"1994"},{"key":"bi9702849b00003\/bi9702849b00003_1","volume-title":"Nature 350, 232\u2212235","author":"MacKinnon R.","year":"1991"},{"key":"bi9702849b00004\/bi9702849b00004_1","volume-title":"Neuron 9, 861\u2212871","author":"Liman E. R.","year":"1992"},{"key":"bi9702849b00005\/bi9702849b00005_1","volume-title":"Neuron 15, 1441\u22121447","author":"Yang J.","year":"1995"},{"key":"bi9702849b00006\/bi9702849b00006_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/362038a0","volume":"362","author":"Ho K.","year":"1993","journal-title":"Nature"},{"key":"bi9702849b00007\/bi9702849b00007_1","volume-title":"Nature 362, 127\u2212132","author":"Kubo Y.","year":"1993"},{"key":"bi9702849b00008\/bi9702849b00008_1","volume-title":"Biochemistry 33, 6834\u22126839","author":"Garcia M. L.","year":"1994"},{"key":"bi9702849b00009\/bi9702849b00009_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 88","author":"Park C.-S.","year":"1991"},{"key":"bi9702849b00010\/bi9702849b00010_1","volume-title":"Biochemistry 32, 6982\u22126987","author":"Escobar L.","year":"1993"},{"key":"bi9702849b00011\/bi9702849b00011_1","volume-title":"Nature 371, 243\u2212246","author":"Lu Z.","year":"1994"},{"key":"bi9702849b00012\/bi9702849b00012_1","volume-title":"Nature 371, 246\u2212249","author":"Wible B. A.","year":"1994"},{"key":"bi9702849b00013\/bi9702849b00013_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF01870284","volume":"109","author":"Lucchesi K.","year":"1989","journal-title":"J. Membrane Biol."},{"key":"bi9702849b00014\/bi9702849b00014_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0006-3495(94)80887-2","volume":"66","author":"Heginbotham L.","year":"1994","journal-title":"Biophys. J."},{"key":"bi9702849b00015\/bi9702849b00015_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.270.25.15336","volume":"270","author":"Schwalbe R. A.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi9702849b00016\/bi9702849b00016_1","volume-title":"Biochemistry 31, 7749\u22127755","author":"Park C.-S.","year":"1992"},{"key":"bi9702849b00017\/bi9702849b00017_1","volume-title":"Biochemistry 33, 443\u2212450","author":"Stampe P.","year":"1994"},{"key":"bi9702849b00018\/bi9702849b00018_1","volume-title":"Neuron 12,1377\u22121388","author":"Goldstein S. A. N.","year":"1994"},{"key":"bi9702849b00019\/bi9702849b00019_1","volume-title":"Science 268, 307\u2212310","author":"Hidalgo P.","year":"1995"},{"key":"bi9702849b00020\/bi9702849b00020_1","volume-title":"Neuron 16, 131\u2212139","author":"Ranganathan R.","year":"1996"},{"key":"bi9702849b00021\/bi9702849b00021_1","volume-title":"Neuron 15, 1169\u22121181","author":"Aiyar J.","year":"1995"},{"key":"bi9702849b00022\/bi9702849b00022_1","volume-title":"Neuron 16, 123\u2212130","author":"Naranjo D.","year":"1996"},{"key":"bi9702849b00023\/bi9702849b00023_1","volume-title":"Science 258, 942\u2212944","author":"Heginbotham L.","year":"1992"},{"key":"bi9702849b00024\/bi9702849b00024_1","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.91.3.335","volume":"91","author":"MacKinnon R.","year":"1988","journal-title":"J. Gen. Physiol."},{"key":"bi9702849b00025\/bi9702849b00025_1","volume-title":"Neuron 9, 307\u2212313","author":"Park C.-S.","year":"1992"},{"key":"bi9702849b00026\/bi9702849b00026_1","volume":"65","author":"Goldstein S. A. N.","year":"1993","journal-title":"Biophys. J."},{"key":"bi9702849b00027\/bi9702849b00027_1","volume-title":"Biochemistry 31, 7756\u22127764","author":"Bontems F.","year":"1992"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi9702849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T15:42:11Z","timestamp":1633621331000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi9702849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,6,1]]},"references-count":27,"journal-issue":{"issue":"23","published-print":{"date-parts":[[1997,6,1]]}},"alternative-id":["10.1021\/bi9702849"],"URL":"https:\/\/doi.org\/10.1021\/bi9702849","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,6,1]]}}}