{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:33:18Z","timestamp":1791037998505,"version":"4.1.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"45","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[1997,11,1]]},"DOI":"10.1021\/bi970737+","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:05:17Z","timestamp":1027659917000},"page":"13929-13937","source":"Crossref","is-referenced-by-count":21,"title":["P-Glycoprotein Is a Dimer in the Kidney and Brain Capillary Membranes:\u2009 Effect of Cyclosporin A and SDZ-PSC 833"],"prefix":"10.1021","volume":"36","author":[{"given":"Lucie","family":"Jett\u00e9","sequence":"first","affiliation":[{"name":"Laboratoire d'oncologie mol\u00e9culaire, d\u00e9partement de chimie-biochimie, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C. P. 8888, Succursale Centre-Ville, Montr\u00e9al, Qu\u00e9bec, Canada H3C 3P8, and H\u00f4pital Ste-Justine, Montr\u00e9al, Qu\u00e9bec Canada, H3T 1C5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Potier","sequence":"additional","affiliation":[{"name":"Laboratoire d'oncologie mol\u00e9culaire, d\u00e9partement de chimie-biochimie, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C. P. 8888, Succursale Centre-Ville, Montr\u00e9al, Qu\u00e9bec, Canada H3C 3P8, and H\u00f4pital Ste-Justine, Montr\u00e9al, Qu\u00e9bec Canada, H3T 1C5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"B\u00e9liveau","sequence":"additional","affiliation":[{"name":"Laboratoire d'oncologie mol\u00e9culaire, d\u00e9partement de chimie-biochimie, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, C. P. 8888, Succursale Centre-Ville, Montr\u00e9al, Qu\u00e9bec, Canada H3C 3P8, and H\u00f4pital Ste-Justine, Montr\u00e9al, Qu\u00e9bec Canada, H3T 1C5"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[1997,11,11]]},"reference":[{"key":"atypb1\/atypb2","first-page":"32","volume":"1233","author":"Beaulieu E.","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"atypb3\/atypb4","volume-title":"Anal. Biochem. 132, 362\u2212364","author":"Beauregard G.","year":"1983"},{"key":"atypb5\/atypb6","volume-title":"Methods Biochem. Anal. 32, 313\u2212343","author":"Beauregard G.","year":"1987"},{"key":"atypb7\/atypb8","volume":"4","author":"B\u00e9liveau R.","year":"1989","journal-title":"News Physiol. Sci."},{"key":"atypb9\/atypb10","volume":"252","author":"B\u00e9liveau R.","year":"1988","journal-title":"Biochem. J."},{"key":"atypb11\/atypb12","volume-title":"Anti-Cancer Drugs 5, 229\u2212238","author":"Boesch D.","year":"1994"},{"key":"atypb13\/atypb14","volume-title":"Cancer Res. 51, 4226\u22124233","author":"Boesch D.","year":"1991"},{"key":"atypb15\/atypb16","doi-asserted-by":"crossref","DOI":"10.1042\/bj1420575","volume":"142","author":"Booth A. G.","year":"1974","journal-title":"Biochem. J."},{"key":"atypb17\/atypb18","volume":"1027","author":"Boscoboinik D.","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"atypb19\/atypb20","volume-title":"Anal. Biochem. 72, 248\u2212254","author":"Bradford M. M.","year":"1976"},{"key":"atypb21\/atypb22","volume-title":"Cell 47, 381\u2212389","author":"Chen C.-J.","year":"1986"},{"key":"atypb23\/atypb24","doi-asserted-by":"crossref","DOI":"10.1177\/38.9.1974900","volume":"38","author":"Cordon-Cardo C.","year":"1990","journal-title":"J. Histochem. Cytochem."},{"key":"atypb25\/atypb26","doi-asserted-by":"crossref","DOI":"10.1042\/bj2760745","volume":"276","author":"Dallaire L.","year":"1991","journal-title":"Biochem. J."},{"key":"atypb27\/atypb28","volume":"42","author":"Ford J. M.","year":"1990","journal-title":"Pharmacol. Rev."},{"key":"atypb29\/atypb30","volume-title":"in The blood-brain barrier. Cellular and molecular biology","author":"Frey A.","year":"1993"},{"key":"atypb31\/atypb32","volume-title":"V. (1990a) Proc. Natl. Acad. Sci. U.S.A. 87","author":"Georges E."},{"key":"atypb33\/atypb34","volume-title":"Adv. Pharmacol. 21, 185\u2212220","author":"Georges E.","year":"1990"},{"key":"atypb35\/atypb36","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)53923-5","volume":"268","author":"Georges E.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"atypb37\/atypb38","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.bi.62.070193.002125","volume":"62","author":"Gottesman M. M.","year":"1993","journal-title":"Annu. Rev. Biochem."},{"key":"atypb39\/atypb40","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(19)76481-3","volume":"262","author":"Greenberger L. M.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"atypb41\/atypb42","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(19)39578-X","volume":"265","author":"Greenberger L. M.","year":"1990","journal-title":"J. Biol. Chem."},{"key":"atypb43\/atypb44","volume-title":"Cell 47, 371\u2212380","author":"Gros P.","year":"1986"},{"key":"atypb45\/atypb46","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0076-6879(85)17009-6","volume":"117","author":"Harmon J. T.","year":"1985","journal-title":"Methods Enzymol."},{"key":"atypb47\/atypb48","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0304-4157(75)90016-7","volume":"415","author":"Helenius A.","year":"1975","journal-title":"Biochim. Biophys. Acta"},{"key":"atypb49\/atypb50","volume":"1073","author":"Ichikawa M.","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"atypb51\/atypb52","volume-title":"Anti-Cancer Drugs 5, 655\u2212665","author":"Jachez B.","year":"1994"},{"key":"atypb53\/atypb54","volume":"1150","author":"Jett\u00e9 L.","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"atypb55\/atypb56","volume-title":"Biochem. Pharmacol. 50, 1701\u22121709","author":"Jett\u00e9 L.","year":"1995"},{"key":"atypb57\/atypb58","doi-asserted-by":"crossref","DOI":"10.1042\/bj3050761","volume":"305","author":"Jett\u00e9 L.","year":"1995","journal-title":"Biochem. J."},{"key":"atypb59\/atypb60","volume":"270","author":"Jett\u00e9 L.","year":"1996","journal-title":"Am. J. Physiol."},{"key":"atypb61\/atypb62","first-page":"126","volume-title":"J. C., & Jung","author":"Jung C. Y.","year":"1988"},{"key":"atypb63\/atypb64","volume":"163","author":"Kepner G. R.","year":"1968","journal-title":"Biochim. Biophys. Acta"},{"key":"atypb65\/atypb66","volume-title":"Nature 227, 680\u2212685","author":"Laemmli U. K.","year":"1970"},{"key":"atypb67\/atypb68","doi-asserted-by":"crossref","DOI":"10.1042\/bj2670431","volume":"267","author":"le Maire M.","year":"1990","journal-title":"Biochem. J."},{"key":"atypb69\/atypb70","volume-title":"Biochem. Biophys. Res. Commun. 162, 244\u2212252","author":"Lieberman D. M.","year":"1989"},{"key":"atypb71\/atypb72","first-page":"109","volume":"13","author":"Lum B. L.","year":"1993","journal-title":"Pharmacotherapy"},{"key":"atypb73\/atypb74","volume-title":"Biochem. Biophys. Res. Commun. 185, 284\u2212290","author":"Naito M.","year":"1992"},{"key":"atypb75\/atypb76","volume-title":"Biochemistry 33, 4163\u22124174","author":"Poruchynsky M. S.","year":"1994"},{"key":"atypb77\/atypb78","volume-title":"Anal. Biochem. 217, 220\u2212230","author":"Sch\u00e4gger H.","year":"1994"},{"key":"atypb79\/atypb80","volume-title":"M. A., Robanus-Maandag, E. C., te Riele, H. P. J.","author":"Schinkel A. H.","year":"1994"},{"key":"atypb81\/atypb82","doi-asserted-by":"crossref","DOI":"10.1177\/37.2.2463300","volume":"37","author":"Thiebaut F.","year":"1989","journal-title":"J. Histochem. Cytochem."},{"key":"atypb83\/atypb84","volume-title":"Biochem. Pharmacol. 43, 109\u2212117","author":"Twentyman P. R.","year":"1992"},{"key":"bi9707371b00001\/bi9707371b00001_1","volume-title":"blue-native polyacrylamide gel electrophoresis","author":"Abbreviations BN-PAGE"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi970737%2B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T22:21:00Z","timestamp":1643840460000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi970737%2B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11,1]]},"references-count":43,"journal-issue":{"issue":"45","published-print":{"date-parts":[[1997,11,1]]}},"alternative-id":["10.1021\/bi970737+"],"URL":"https:\/\/doi.org\/10.1021\/bi970737+","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11,1]]}}}