{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:01:28Z","timestamp":1782212488341,"version":"3.54.5"},"reference-count":41,"publisher":"American Chemical Society (ACS)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[1998,5,1]]},"DOI":"10.1021\/bi973011m","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:17:50Z","timestamp":1027660670000},"page":"7407-7419","source":"Crossref","is-referenced-by-count":59,"title":["Mechanism-Based Inactivation of Human Cytochrome P450 1A2 by Furafylline:\u2009 Detection of a 1:1 Adduct to Protein and Evidence for the Formation of a Novel Imidazomethide Intermediate"],"prefix":"10.1021","volume":"37","author":[{"given":"Jagdish K.","family":"Racha","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan E.","family":"Rettie","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kent L.","family":"Kunze","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[1998,4,28]]},"reference":[{"key":"bi973011mX00001\/bi973011mX00001_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-2391-5","volume-title":"Cytochrome P450:\u2009 Structure, Mechanism and Biochemistry","author":"Ortiz de Montellano P. R.","year":"1995"},{"key":"bi973011mX00002\/bi973011mX00002_1","volume-title":"Cytochrome P450:\u2009 Structure, Mechanism and Biochemistry","author":"Von Wachenfeldt C.","year":"1995"},{"key":"bi973011mX00003\/bi973011mX00003_1","volume-title":"Pharmacogenetics 5, 249\u2212274","author":"Eaton D. L.","year":"1995"},{"key":"bi973011mX00004\/bi973011mX00004_1","volume":"28","author":"Sesardic D.","year":"1990","journal-title":"Br. J. Clin. Pharmacol."},{"key":"bi973011mX00005\/bi973011mX00005_1","volume-title":"Chem. Res. Toxicol. 6, 649\u2212656","author":"Kunze K. L.","year":"1993"},{"key":"bi973011mX00006\/bi973011mX00006_1","volume-title":"Drug Metab. Dispos. 24, 414\u2212421","author":"Kunze K. L.","year":"1996"},{"key":"bi973011mX00007\/bi973011mX00007_1","volume":"265","author":"Tassaneeyakul W.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"bi973011mX00008\/bi973011mX00008_1","volume-title":"Pharmacogenetics 4, 281\u2212284","author":"Tassaneeyakul W.","year":"1994"},{"key":"bi973011mX00009\/bi973011mX00009_1","volume-title":"Toxicol. Appl. Pharmacol. 141, 595\u2212606","author":"Gallagher E. P.","year":"1996"},{"key":"bi973011mX00010\/bi973011mX00010_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1365-2125.1987.tb03003.x","volume":"23","author":"Tarrus E.","year":"1987","journal-title":"Br. J. Clin. Pharmacol."},{"key":"bi973011mX00011\/bi973011mX00011_1","first-page":"94","volume":"54","author":"Boobis A. R.","year":"1994","journal-title":"Cancer Res."},{"key":"bi973011mX00012\/bi973011mX00012_1","volume-title":"The Purines","volume":"54","author":"Lister J. H.","year":"1996"},{"key":"bi973011mX00013\/bi973011mX00013_1","volume-title":"Biochem. Biophys. Res. Commun. 160, 844\u2212849","author":"Ling K. J.","year":"1989"},{"key":"bi973011mX00014\/bi973011mX00014_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja00310a066","volume":"107","author":"Hanzlik R. P.","year":"1985","journal-title":"J. Am. Chem. Soc."},{"key":"bi973011mX00015\/bi973011mX00015_1","volume-title":"Biochemistry 33, 2927\u22122937","author":"Gillette J. R.","year":"1994"},{"key":"bi973011mX00016\/bi973011mX00016_1","volume-title":"Mechanism-Based Enzyme Inactivation:\u2009 Chemistry and Enzymology","volume":"1","author":"Silverman R.","year":"1988"},{"key":"bi973011mX00017\/bi973011mX00017_1","first-page":"29","volume":"276","author":"Thorton-Manning J.","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"bi973011mX00018\/bi973011mX00018_1","volume-title":"Chem. Res. Toxicol. 9, 291\u2212297","author":"Skiles G. L.","year":"1996"},{"key":"bi973011mX00019\/bi973011mX00019_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0041-008X(85)90122-X","volume":"81","author":"Nocerini M. R.","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"bi973011mX00020\/bi973011mX00020_1","author":"More O'Ferral R. A.","year":"1970","journal-title":"J. Chem. Soc. B, 785\u2212790."},{"key":"bi973011mX00021\/bi973011mX00021_1","volume-title":"Tetrahedron 33, 2259\u22122266","author":"Zvilichovsky G.","year":"1977"},{"key":"bi973011mX00022\/bi973011mX00022_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-2391-5","volume-title":"Cytochrome P450:\u2009 Structure, Mechanism and Biochemistry","author":"Ortiz de Montellano P. R.","year":"1995"},{"key":"bi973011mX00023\/bi973011mX00023_1","volume-title":"Xenobiotica 25, 689\u2212709","author":"Guengerich F. P.","year":"1995"},{"key":"bi973011mX00024\/bi973011mX00024_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.44.27321","volume":"271","author":"Guengerich F. P.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"bi973011mX00025\/bi973011mX00025_1","volume-title":"Xenobiotica 25, 710\u2212724","author":"Karki S. B.","year":"1995"},{"key":"bi973011mX00026\/bi973011mX00026_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja00118a001","volume":"117","author":"Karki S. B.","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"bi973011mX00027\/bi973011mX00027_1","volume":"117","author":"Newcomb M.","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"bi973011mX00028\/bi973011mX00028_1","volume-title":"Cytochrome P450:\u2009 Structure, Mechanism and Biochemistry","author":"Groves J. T.","year":"1995"},{"key":"bi973011mX00029\/bi973011mX00029_1","volume":"108","author":"White R. E.","year":"1988","journal-title":"J. Am. Chem. Soc."},{"key":"bi973011mX00030\/bi973011mX00030_1","volume-title":"Trends Pharmacol. Sci. 10, 354\u2212359","author":"Ortiz de Montellano P. R.","year":"1989"},{"key":"bi973011mX00031\/bi973011mX00031_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)68302-4","volume":"263","author":"Rettie A. R.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"bi973011mX00032\/bi973011mX00032_1","volume-title":"Drug Metab. Dispos. 18, 974\u2212979","author":"Korzekwa K. R.","year":"1990"},{"key":"bi973011mX00033\/bi973011mX00033_1","volume-title":"Drug Metab. Dispos. 21, 242\u2212248","author":"Kassahun K.","year":"1993"},{"key":"bi973011mX00034\/bi973011mX00034_1","volume":"111","author":"Watanabe Y.","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"bi973011mX00035\/bi973011mX00035_1","volume-title":"Drug Metab. Dispos. 18, 218\u2212222","author":"Vyas K. P.","year":"1990"},{"key":"bi973011mX00036\/bi973011mX00036_1","unstructured":"Koymans, L., Van Lenthe, J. H., Donne-Op Den Kelder, M., and Vermeulen, N. P. E. (1990)Mol. Pharmacol. 37, 452\u2212460."},{"key":"bi973011mX00037\/bi973011mX00037_1","unstructured":"Hinson, J. A., Nelson, S. D., and Gillette, J. R. (1979)Mol. Pharmacol.15, 419\u2212427."},{"key":"bi973011mX00038\/bi973011mX00038_1","volume-title":"Xenobiotica 26, 723\u2212753","author":"Lewis D. F. V.","year":"1996"},{"key":"bi973011mX00039\/bi973011mX00039_1","doi-asserted-by":"crossref","DOI":"10.1023\/A:1007947411145","volume":"11","author":"Lozano J. J.","year":"1997","journal-title":"J. Comput. Aided Mol. Des."},{"key":"bi973011mX00040\/bi973011mX00040_1","author":"Lichetenberg D.","year":"1971","journal-title":"J. Chem. Soc. C, 1676\u22121682."},{"key":"bi973011mb00001\/bi973011mb00001_1","volume-title":"human cytochrome P450 1A2","author":"Abbreviations"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi973011m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T05:49:08Z","timestamp":1634449748000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi973011m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4,28]]},"references-count":41,"journal-issue":{"issue":"20","published-print":{"date-parts":[[1998,5,1]]}},"alternative-id":["10.1021\/bi973011m"],"URL":"https:\/\/doi.org\/10.1021\/bi973011m","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4,28]]}}}