{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:31:20Z","timestamp":1789403480681,"version":"build-2803163510"},"reference-count":70,"publisher":"American Chemical Society (ACS)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2000,3,1]]},"DOI":"10.1021\/bi992302n","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T05:51:53Z","timestamp":1027662713000},"page":"2726-2732","source":"Crossref","is-referenced-by-count":26,"title":["Action of Quinolones against <i>Staphylococcus aureus<\/i> Topoisomerase IV:\u2009 Basis for DNA Cleavage Enhancement"],"prefix":"10.1021","volume":"39","author":[{"given":"Virginia E.","family":"Anderson","sequence":"first","affiliation":[{"name":"Departments of Biochemistry and Medicine (Hematology\/Oncology),Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and the Department of Cancer, Immunology, and Infectious Diseases, Pfizer Central Research, Pfizer, Inc., Groton Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Zaniewski","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Medicine (Hematology\/Oncology),Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and the Department of Cancer, Immunology, and Infectious Diseases, Pfizer Central Research, Pfizer, Inc., Groton Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank S.","family":"Kaczmarek","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Medicine (Hematology\/Oncology),Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and the Department of Cancer, Immunology, and Infectious Diseases, Pfizer Central Research, Pfizer, Inc., Groton Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Gootz","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Medicine (Hematology\/Oncology),Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and the Department of Cancer, Immunology, and Infectious Diseases, Pfizer Central Research, Pfizer, Inc., Groton Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Osheroff","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry and Medicine (Hematology\/Oncology),Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, and the Department of Cancer, Immunology, and Infectious Diseases, Pfizer Central Research, Pfizer, Inc., Groton Connecticut 06340"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2000,2,17]]},"reference":[{"key":"bi992302nb00001\/bi992302nb00001_1","volume-title":"Mol. Microbiol. 15, 601\u2212606","author":"Luttinger A.","year":"1995"},{"key":"bi992302nb00002\/bi992302nb00002_1","volume":"65","author":"Wang J. C.","year":"1996","journal-title":"Annu. Rev. Biochem."},{"key":"bi992302nb00003\/bi992302nb00003_1","first-page":"44","volume":"1400","author":"Levine C.","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"bi992302nb00004\/bi992302nb00004_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 73, 3872\u22123876","author":"Gellert M.","year":"1976"},{"key":"bi992302nb00005\/bi992302nb00005_1","doi-asserted-by":"crossref","DOI":"10.1128\/jb.140.2.424-435.1979","volume":"140","author":"Kreuzer K. N.","year":"1979","journal-title":"J. Bacteriol."},{"key":"bi992302nb00006\/bi992302nb00006_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0092-8674(82)90402-0","volume":"31","author":"Pruss G. J.","year":"1982","journal-title":"Cell"},{"key":"bi992302nb00007\/bi992302nb00007_1","volume-title":"Pharmacol. Ther. 41, 223\u2212241","author":"Osheroff N.","year":"1989"},{"key":"bi992302nb00008\/bi992302nb00008_1","doi-asserted-by":"crossref","DOI":"10.3109\/10409239109114072","volume":"26","author":"Reece R. J.","year":"1991","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"bi992302nb00009\/bi992302nb00009_1","first-page":"69","volume":"29","author":"Menzel R.","year":"1994","journal-title":"Adv. Pharmacol."},{"key":"bi992302nb00010\/bi992302nb00010_1","volume-title":"Cold Spring Harbor Symp. Quantum Biol. 33, 677\u2212694","author":"Hirota Y.","year":"1968"},{"key":"bi992302nb00011\/bi992302nb00011_1","volume":"170","author":"Kato J.-I.","year":"1988","journal-title":"J. Bacteriol."},{"key":"bi992302nb00012\/bi992302nb00012_1","volume-title":"Cell 63, 393\u2212404","author":"Kato J.","year":"1990"},{"key":"bi992302nb00013\/bi992302nb00013_1","volume-title":"Cell 71, 277\u2212288","author":"Adams D. E.","year":"1992"},{"key":"bi992302nb00014\/bi992302nb00014_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 90, 8571\u22128575","author":"Peng H.","year":"1993"},{"key":"bi992302nb00015\/bi992302nb00015_1","volume-title":"Genes Dev. 9, 2859\u22122869","author":"Zechiedrich E. L.","year":"1995"},{"key":"bi992302nb00016\/bi992302nb00016_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.49.31549","volume":"271","author":"Ullsperger C.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00017\/bi992302nb00017_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 74, 4772\u22124776","author":"Gellert M.","year":"1977"},{"key":"bi992302nb00018\/bi992302nb00018_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 74, 4767\u22124771","author":"Sugino A.","year":"1977"},{"key":"bi992302nb00019\/bi992302nb00019_1","volume":"267","author":"Kato J.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00020\/bi992302nb00020_1","volume":"268","author":"Peng H.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00021\/bi992302nb00021_1","volume-title":"Mol. Microbiol. 13, 641\u2212653","author":"Ferrero L.","year":"1994"},{"key":"bi992302nb00022\/bi992302nb00022_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 92, 11801\u221211805","author":"Khodursky A. B.","year":"1995"},{"key":"bi992302nb00023\/bi992302nb00023_1","volume":"270","author":"Froelich-Ammon S. J.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00024\/bi992302nb00024_1","volume-title":"Agents Chemother. 40","author":"Ng E. Y.","year":"1996"},{"key":"bi992302nb00025\/bi992302nb00025_1","volume-title":"Antimicrob. Agents Chemother. 40, 2252\u22122257","author":"Munoz R.","year":"1996"},{"key":"bi992302nb00026\/bi992302nb00026_1","volume-title":"Antimicrob. Agents Chemother. 40, 2321\u22122326","author":"Pan X.-S.","year":"1996"},{"key":"bi992302nb00027\/bi992302nb00027_1","volume-title":"Antimicrob. Agents Chemother. 40, 2691\u22122697","author":"Gootz T. D.","year":"1996"},{"key":"bi992302nb00028\/bi992302nb00028_1","volume-title":"Trends Microbiol. 5, 102\u2212109","author":"Maxwell A.","year":"1997"},{"key":"bi992302nb00029\/bi992302nb00029_1","volume":"61","author":"Drlica K.","year":"1997","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"bi992302nb00030\/bi992302nb00030_1","volume-title":"S54\u2212S63.","author":"Hooper D. C.","year":"1998"},{"key":"bi992302nb00031\/bi992302nb00031_1","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM199102073240606","volume":"324","author":"Hooper D. C.","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"bi992302nb00032\/bi992302nb00032_1","first-page":"14","volume":"3","author":"Hooper D. C.","year":"1993","journal-title":"Drugs"},{"key":"bi992302nb00033\/bi992302nb00033_1","doi-asserted-by":"crossref","DOI":"10.1002\/(SICI)1098-1128(199609)16:5<433::AID-MED3>3.0.CO;2-W","volume":"16","author":"Gootz T. D.","year":"1996","journal-title":"Med. Res. Rev."},{"key":"bi992302nb00034\/bi992302nb00034_1","first-page":"61","volume":"1400","author":"Hooper D. C.","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"bi992302nb00035\/bi992302nb00035_1","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/30.4.409","volume":"30","author":"Maxwell A.","year":"1992","journal-title":"J. Antimicrob. Chemother."},{"key":"bi992302nb00036\/bi992302nb00036_1","volume":"273","author":"Anderson V. E.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00037\/bi992302nb00037_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.273.42.27668","volume":"273","author":"Khodursky A. B.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00038\/bi992302nb00038_1","doi-asserted-by":"crossref","DOI":"10.1128\/jb.172.6.3481-3484.1990","volume":"172","author":"Hopewell R.","year":"1990","journal-title":"J. Bacteriol."},{"key":"bi992302nb00039\/bi992302nb00039_1","volume-title":"Agents Chemother. 43","author":"Gootz T. D.","year":"1999"},{"key":"bi992302nb00040\/bi992302nb00040_1","volume-title":"Antimicrob. Agents Chemother. 43, 1129\u22121136","author":"Pan X.-S.","year":"1999"},{"key":"bi992302nb00041\/bi992302nb00041_1","volume-title":"Antimicrob. Agents Chemother. 43, 1574\u22121577","author":"Saiki A. Y.","year":"1999"},{"key":"bi992302nb00042\/bi992302nb00042_1","volume-title":"Antimicrob. Agents Chemother. 39, 2210\u22122116","author":"Girard A. E.","year":"1995"},{"key":"bi992302nb00043\/bi992302nb00043_1","author":"Brighty K. E.","year":"1997","journal-title":"J. Antimicrob. Chemother. 39 (Suppl B), 1\u221214."},{"key":"bi992302nb00044\/bi992302nb00044_1","volume":"17","author":"Pech\u00e8re J.-C.","year":"1998","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"bi992302nb00045\/bi992302nb00045_1","volume":"274","author":"Anderson V. E.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00046\/bi992302nb00046_1","volume-title":"Gene 93, 139\u2212142","author":"Hallett P.","year":"1990"},{"key":"bi992302nb00047\/bi992302nb00047_1","volume-title":"Molecular Cloning:\u2009 A Laboratory Manual","author":"Sambrook J.","year":"1989","edition":"2"},{"key":"bi992302nb00048\/bi992302nb00048_1","volume-title":"Cell 14, 157\u2212168","author":"Englund P. T.","year":"1978"},{"key":"bi992302nb00049\/bi992302nb00049_1","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.271.46.29238","volume":"271","author":"Burden D. A.","year":"1996","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00050\/bi992302nb00050_1","volume":"266","author":"Corbett A. H.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00051\/bi992302nb00051_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)41531-1","volume":"268","author":"Knab A.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00052\/bi992302nb00052_1","volume-title":"Antimicrob. Agents Chemother. 40, 2691\u22122697","author":"Gootz T. D.","year":"1996"},{"key":"bi992302nb00053\/bi992302nb00053_1","volume-title":"Antimicrob. Agents Chemother. 41, 471\u2212474","author":"Pan X.-S.","year":"1997"},{"key":"bi992302nb00054\/bi992302nb00054_1","volume-title":"Antimicrob. Agents Chemother. 37, 126\u2212127","author":"Willmott C. J.","year":"1993"},{"key":"bi992302nb00055\/bi992302nb00055_1","volume-title":"Adv. Pharmacol. 29B, 271\u2212297","author":"Caron P. C.","year":"1994"},{"key":"bi992302nb00056\/bi992302nb00056_1","volume-title":"Antimicrob. Agents Chemother. 42, 2122\u22122124","author":"Fitzgibbon J. E.","year":"1998"},{"key":"bi992302nb00057\/bi992302nb00057_1","volume":"266","author":"Robinson M. J.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00058\/bi992302nb00058_1","volume-title":"Antimicrob. Agents Chemother. 37, 2179\u22122186","author":"Elsea S. H.","year":"1993"},{"key":"bi992302nb00059\/bi992302nb00059_1","volume-title":"Antimicrob. Agents Chemother. 38, 2623\u22122627","author":"Hoshino K.","year":"1994"},{"key":"bi992302nb00060\/bi992302nb00060_1","volume-title":"Antimicrob. Agents Chemother. 33, 1697\u22121703","author":"Barrett J. F.","year":"1989"},{"key":"bi992302nb00061\/bi992302nb00061_1","volume-title":"Antimicrob. Agents Chemother. 36, 751\u2212756","author":"Robinson M. J.","year":"1992"},{"key":"bi992302nb00062\/bi992302nb00062_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)42185-0","volume":"267","author":"Elsea S. H.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"bi992302nb00063\/bi992302nb00063_1","volume-title":"Cancer Res. 52, 2818\u22122822","author":"Yamashita Y.","year":"1992"},{"key":"bi992302nb00064\/bi992302nb00064_1","volume-title":"Antimicrob. Agents Chemother. 37, 646\u2212651","author":"Froelich-Ammon S. J.","year":"1993"},{"key":"bi992302nb00065\/bi992302nb00065_1","volume-title":"Chem. Res. Toxicol. 6, 585\u2212597","author":"Corbett A. H.","year":"1993"},{"key":"bi992302nb00066\/bi992302nb00066_1","volume-title":"in Quinolone Antimicrobial Agents","author":"Gootz T.","year":"1993"},{"key":"bi992302nb00067\/bi992302nb00067_1","volume-title":"Mol. Pharmacol. 48, 238\u2212249","author":"Spitzner J. R.","year":"1995"},{"key":"bi992302nb00068\/bi992302nb00068_1","volume-title":"Biochem. Pharmacol. 50, 111\u2212122","author":"Coughlin S. A.","year":"1995"},{"key":"bi992302nb00069\/bi992302nb00069_1","volume-title":"Cancer Res. 55, 830\u2212835","author":"Clement J. J.","year":"1995"},{"key":"bi992302nn00001\/bi992302nn00001_1","volume-title":"kinetoplast DNA","author":"Abbreviations DNA"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi992302n","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T04:29:58Z","timestamp":1678163398000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi992302n"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2,17]]},"references-count":70,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,3,1]]}},"alternative-id":["10.1021\/bi992302n"],"URL":"https:\/\/doi.org\/10.1021\/bi992302n","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,2,17]]}}}