{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:35:13Z","timestamp":1791268513413,"version":"4.1.0"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2006,12,1]]},"DOI":"10.1021\/bm060788z","type":"journal-article","created":{"date-parts":[[2006,11,14]],"date-time":"2006-11-14T12:01:25Z","timestamp":1163505685000},"page":"3428-3438","source":"Crossref","is-referenced-by-count":78,"title":["Stabilized Nanocarriers for Plasmids Based Upon Cross-linked Poly(ethylene imine)"],"prefix":"10.1021","volume":"7","author":[{"given":"Michael","family":"Neu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics and Biopharmacy, Philipps Universit\u00e4t, 35037 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Sitterberg","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Biopharmacy, Philipps Universit\u00e4t, 35037 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Bakowsky","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Biopharmacy, Philipps Universit\u00e4t, 35037 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kissel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Biopharmacy, Philipps Universit\u00e4t, 35037 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,11,14]]},"reference":[{"key":"bm060788zb00001\/bm060788zb00001_1","first-page":"192","volume":"8","author":"Ohana P.","year":"2004","journal-title":"Gene Ther. Mol. Biol."},{"key":"bm060788zb00002\/bm060788zb00002_1","first-page":"10","volume":"1523","author":"Mullen P. M.","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"bm060788zb00003\/bm060788zb00003_1","first-page":"9","volume":"97","author":"Ward C. M.","year":"2001","journal-title":"Blood"},{"key":"bm060788zb00004\/bm060788zb00004_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0378-5173(00)00642-6","volume":"214","author":"Verbaan F. J.","year":"2001","journal-title":"Int. J. Pharm."},{"key":"bm060788zb00005\/bm060788zb00005_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0090-9556(24)02982-9","volume":"32","author":"Fischer D.","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"bm060788zb00006\/bm060788zb00006_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1021\/ja0522332","volume":"127","author":"Chittimalla C.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"bm060788zb00007\/bm060788zb00007_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/A:1016152831963","volume":"19","author":"Kunath K.","year":"2002","journal-title":"Pharm. Res."},{"key":"bm060788zb00008\/bm060788zb00008_1","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1038\/sj.gt.3301039","volume":"6","author":"Bragonzi A.","year":"1999","journal-title":"Gene Ther."},{"key":"bm060788zb00009\/bm060788zb00009_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/sj.gt.3300900","volume":"6","author":"Ogris M.","year":"1999","journal-title":"Gene Ther."},{"key":"bm060788zb00010\/bm060788zb00010_1","first-page":"50","volume":"6","author":"Dash P. R.","year":"1999","journal-title":"Gene Ther."},{"key":"bm060788zb00011\/bm060788zb00011_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/bm034083y","volume":"4","author":"Tseng W. C.","year":"2003","journal-title":"Biomacromolecules"},{"key":"bm060788zb00012\/bm060788zb00012_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1023\/B:PHAM.0000012146.04068.56","volume":"21","author":"Wagner E.","year":"2004","journal-title":"Pharm. Res."},{"key":"bm060788zb00013\/bm060788zb00013_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1021\/bm050524x","volume":"7","author":"Subr V.","year":"2006","journal-title":"Biomacromolecules"},{"key":"bm060788zb00014\/bm060788zb00014_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jgm.475","volume":"6","author":"Verbaan F. J.","year":"2004","journal-title":"J. Gene Med."},{"key":"bm060788zb00015\/bm060788zb00015_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0168-3659(03)00230-X","volume":"91","author":"Ogris M.","year":"2003","journal-title":"J. Controlled Release"},{"key":"bm060788zb00016\/bm060788zb00016_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1021\/bc990143e","volume":"11","author":"Oupicky D.","year":"2000","journal-title":"Bioconjug. Chem."},{"key":"bm060788zb00017\/bm060788zb00017_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1021\/bc049743q","volume":"16","author":"Merdan T.","year":"2005","journal-title":"Bioconjug. Chem."},{"key":"bm060788zb00018\/bm060788zb00018_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/10611860290016685","volume":"10","author":"Oupicky D.","year":"2002","journal-title":"J. Drug Target"},{"key":"bm060788zb00019\/bm060788zb00019_1","first-page":"802","volume":"275","author":"Dash P. R.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"bm060788zb00020\/bm060788zb00020_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/ja016440n","volume":"124","author":"Oupicky D.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"bm060788zb00021\/bm060788zb00021_1","first-page":"8343","volume":"122","author":"Bronich T. K.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"bm060788zb00022\/bm060788zb00022_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/sj.gt.3301446","volume":"8","author":"Oupicky D.","year":"2001","journal-title":"Gene Ther."},{"key":"bm060788zb00023\/bm060788zb00023_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0939-6411(98)00038-1","volume":"46","author":"Roser M.","year":"1998","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"bm060788zb00024\/bm060788zb00024_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1021\/ja0379666","volume":"126","author":"Miyata K.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"bm060788zb00025\/bm060788zb00025_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jgm.525","volume":"6","author":"Carlisle R. C.","year":"2004","journal-title":"J. Gene Med."},{"key":"bm060788zb00026\/bm060788zb00026_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/bc010070a","volume":"13","author":"Park Y.","year":"2002","journal-title":"Bioconjug. Chem."},{"key":"bm060788zb00027\/bm060788zb00027_1","first-page":"1009","volume":"7","author":"Neu M.","year":"2005","journal-title":"J. Gene Med."},{"key":"bm060788zb00028\/bm060788zb00028_1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0169-409X(02)00046-7","volume":"54","author":"Merdan T.","year":"2002","journal-title":"Adv. Drug Delivery Rev."},{"key":"bm060788zb00029\/bm060788zb00029_1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1089\/hum.1996.7.16-1947","volume":"7","author":"Abdallah B.","year":"1996","journal-title":"Hum. Gene Ther."},{"key":"bm060788zb00030\/bm060788zb00030_1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0043-1354(02)00410-4","volume":"37","author":"Ghoul M.","year":"2003","journal-title":"Water Res."},{"key":"bm060788zb00031\/bm060788zb00031_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1081\/JLC-120017165","volume":"26","author":"Sakata M.","year":"2003","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"bm060788zb00032\/bm060788zb00032_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1021\/bc0100455","volume":"12","author":"Gosselin M. A.","year":"2001","journal-title":"Bioconjug. Chem."},{"key":"bm060788zb00033\/bm060788zb00033_1","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s11095-004-1874-y","volume":"22","author":"Thomas M.","year":"2005","journal-title":"Pharm. Res."},{"key":"bm060788zb00034\/bm060788zb00034_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0168-3659(00)00317-5","volume":"69","author":"von Harpe A.","year":"2000","journal-title":"J. Controlled Release"},{"key":"bm060788zb00035\/bm060788zb00035_1","first-page":"100","volume":"461","author":"Read M. L.","year":"1999","journal-title":"FEBS Lett."},{"key":"bm060788zb00036\/bm060788zb00036_1","first-page":"4","volume":"23","author":"Iznaga Escobar N.","year":"1996","journal-title":"Nucl. Med. Biol."},{"key":"bm060788zb00037\/bm060788zb00037_1","first-page":"9","volume":"143","author":"Thannhauser T. W.","year":"1987","journal-title":"Methods Enzymol."},{"key":"bm060788zb00038\/bm060788zb00038_1","first-page":"1873","volume":"64","author":"Hutter J. L.","year":"1993","journal-title":"Rev. Sci. Instrum."},{"key":"bm060788zb00039\/bm060788zb00039_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jconrel.2005.09.036","volume":"109","author":"Kleemann E.","year":"2005","journal-title":"J. Controlled Release"},{"key":"bm060788zb00040\/bm060788zb00040_1","first-page":"54","volume":"13","author":"Petersen H.","year":"2002","journal-title":"Bioconjug. Chem."},{"key":"bm060788zb00041\/bm060788zb00041_1","first-page":"146","volume":"3","author":"Kwok K. Y.","year":"2001","journal-title":"Curr. Opin. Mol. Ther."},{"key":"bm060788zb00042\/bm060788zb00042_1","first-page":"5298","volume":"27","author":"Wang Y.","year":"2006","journal-title":"Biomaterials"},{"key":"bm060788zb00043\/bm060788zb00043_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0006-291X(75)90704-4","volume":"63","author":"Ruoho A.","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"bm060788zb00044\/bm060788zb00044_1","first-page":"1330","volume":"8","author":"Suh J.","year":"1998","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"bm060788zb00045\/bm060788zb00045_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0168-3659(03)00076-2","volume":"89","author":"Kunath K.","year":"2003","journal-title":"J. Controlled Release"},{"key":"bm060788zb00046\/bm060788zb00046_1","unstructured":"Petersen, H. Structurally Modified Polyethylenimines and their Interpolyelectrolyte Complexes with DNA as Non-Viral Gene Delivery Systems. Ph.D. Thesis, Philipps Universit\u00e4t Marburg, 2002."},{"key":"bm060788zb00047\/bm060788zb00047_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1021\/bc025512c","volume":"13","author":"Gosselin M. A.","year":"2002","journal-title":"Bioconjug. Chem."},{"key":"bm060788zb00048\/bm060788zb00048_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1023\/A:1014861900478","volume":"16","author":"Fischer D.","year":"1999","journal-title":"Pharm. Res."},{"key":"bm060788zb00049\/bm060788zb00049_1","first-page":"87","volume":"276","author":"Liu G.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"bm060788zb00050\/bm060788zb00050_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jconrel.2004.09.005","volume":"100","author":"Kleemann E.","year":"2004","journal-title":"J. Controlled Release"},{"key":"bm060788zb00051\/bm060788zb00051_1","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1021\/ma040135f","volume":"38","author":"Cappella B.","year":"2005","journal-title":"Macromolecules"},{"key":"bm060788zb00052\/bm060788zb00052_1","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1021\/ma052727j","volume":"39","author":"Tranchida D.","year":"2006","journal-title":"Macromolecules"},{"key":"bm060788zb00053\/bm060788zb00053_1","first-page":"762","volume":"76","author":"Aime J. P.","year":"1994","journal-title":"J. Appl. Phys."},{"key":"bm060788zb00054\/bm060788zb00054_1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.5254\/1.3547629","volume":"73","author":"Mareanukroh M.","year":"2000","journal-title":"Rubber Chem. Technol."},{"key":"bm060788zb00055\/bm060788zb00055_1","first-page":"16","volume":"5","author":"Richert L.","year":"2004","journal-title":"Biomacromolecules"},{"key":"bm060788zb00056\/bm060788zb00056_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/jemt.20275","volume":"69","author":"Francius G.","year":"2006","journal-title":"Microsc. Res. Tech."},{"key":"bm060788zb00057\/bm060788zb00057_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1021\/bm000142l","volume":"2","author":"Kakizawa Y.","year":"2001","journal-title":"Biomacromolecules"},{"key":"bm060788zb00058\/bm060788zb00058_1","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1021\/bc9801530","volume":"10","author":"Trubetskoy V. S.","year":"1999","journal-title":"Bioconjug. Chem."},{"key":"bm060788zb00059\/bm060788zb00059_1","first-page":"6874","volume":"35","author":"Petersen H.","year":"2002","journal-title":"Macromolecules"},{"key":"bm060788zb00060\/bm060788zb00060_1","first-page":"31","volume":"24","author":"Fischer D.","year":"2003","journal-title":"Biomaterials"},{"key":"bm060788zb00061\/bm060788zb00061_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0378-5173(98)00378-0","volume":"178","author":"Richardson S. C.","year":"1999","journal-title":"Int. J. Pharm."},{"key":"bm060788zb00062\/bm060788zb00062_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/jgm.173","volume":"3","author":"Kichler A.","year":"2001","journal-title":"J. Gene Med."}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bm060788z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T23:02:24Z","timestamp":1736636544000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bm060788z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,14]]},"references-count":62,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12,1]]}},"alternative-id":["10.1021\/bm060788z"],"URL":"https:\/\/doi.org\/10.1021\/bm060788z","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,14]]}}}