{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:40:33Z","timestamp":1776274833193,"version":"3.50.1"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"9","funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2013CB834702"],"award-info":[{"award-number":["2013CB834702"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21025415"],"award-info":[{"award-number":["21025415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21174040"],"award-info":[{"award-number":["21174040"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundamental Research Funds for the Central Universities, South China University of Technology","award":["201401"],"award-info":[{"award-number":["201401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2014,9,8]]},"DOI":"10.1021\/bm500890d","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T20:55:24Z","timestamp":1406580924000},"page":"3383-3389","source":"Crossref","is-referenced-by-count":62,"title":["Ratiometric Fluorescent Biosensor for Hyaluronidase with Hyaluronan As Both Nanoparticle Scaffold and Substrate for Enzymatic Reaction"],"prefix":"10.1021","volume":"15","author":[{"given":"Huafei","family":"Xie","sequence":"first","affiliation":[{"name":"College of Materials Science & Engineering, State Key Laboratory of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Materials Science & Engineering, State Key Laboratory of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuizhu","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Materials Science & Engineering, State Key Laboratory of Luminescent Materials & Devices, South China University of Technology, Guangzhou 510640, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2014,8,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/cncr.25565","volume":"117","author":"Kramer M. W.","year":"2011","journal-title":"Cancer"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.semcancer.2008.03.008","volume":"18","author":"Lokeshwar V. B.","year":"2008","journal-title":"Semin. Cancer Biol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/bm201143c","volume":"13","author":"Veiseh M.","year":"2012","journal-title":"Biomacromolecules"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/ijc.25460","volume":"128","author":"Tan J. X.","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1158\/2159-8290.CD-11-0136","volume":"1","author":"Whatcott C. J.","year":"2011","journal-title":"Cancer Discovery"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1021\/bi700382g","volume":"46","author":"Chao K. L.","year":"2007","journal-title":"Biochemistry"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/cncr.10652","volume":"95","author":"Lokeshwar V. B.","year":"2002","journal-title":"Cancer"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1021\/bm5003009","volume":"15","author":"Zhong Y.","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"11219","DOI":"10.1158\/0008-5472.CAN-06-1121","volume":"66","author":"Lokeshwar V. B.","year":"2006","journal-title":"Cancer Res."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1021\/bm401524h","volume":"15","author":"Roberts J. J.","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/cncr.20902","volume":"103","author":"Eissa S.","year":"2005","journal-title":"Cancer"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1158\/1535-7163.MCT-10-0470","volume":"9","author":"Thompson C. B.","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"9672","DOI":"10.1021\/nn3031047","volume":"6","author":"Fennouri A.","year":"2012","journal-title":"ACS Nano"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0020705","volume":"6","author":"Yoffou P. H.","year":"2011","journal-title":"PLoS One"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1016\/j.biomaterials.2008.08.038","volume":"29","author":"Lee H.","year":"2008","journal-title":"Biomaterials"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bios.2013.10.024","volume":"54","author":"Nossier A. I.","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2174\/13892010113149990222","volume":"14","author":"Chib R.","year":"2013","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1039\/c2cs00004k","volume":"41","author":"Du J. J.","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nchem.1500","volume":"4","author":"Chan J.","year":"2012","journal-title":"Nat. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1021\/cr400546e","volume":"114","author":"Carter K. P.","year":"2014","journal-title":"Chem. Rev."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1021\/bm500296n","volume":"15","author":"Bacinello D.","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1039\/c2cc33555g","volume":"48","author":"Mok H. M.","year":"2012","journal-title":"Chem. Commun."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1039\/c2cs35103j","volume":"41","author":"Hu J. M.","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00014E"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1039\/C4CS00039K","volume":"43","author":"Wang X. D.","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1021\/bm401548u","volume":"14","author":"Yu C. M.","year":"2013","journal-title":"Biomacromolecules"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1039\/C3CS60271K","volume":"43","author":"Guo Z. Q.","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1021\/bm101449b","volume":"12","author":"Deng Y. H.","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1039\/c3cs60055f","volume":"42","author":"Yin C. X.","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1039\/c3cs35429f","volume":"42","author":"Santos-Figueroa L. E.","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1021\/cr300358b","volume":"113","author":"Lee M. H.","year":"2013","journal-title":"Chem. Rev."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1021\/bm801194n","volume":"10","author":"Attar H. A. Al.","year":"2009","journal-title":"Biomacromolecules"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1021\/ar300273v","volume":"46","author":"Yuan L.","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"7834","DOI":"10.1039\/c3cs60102a","volume":"42","author":"Wang X.","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1021\/bm400569k","volume":"14","author":"Wu F.","year":"2013","journal-title":"Biomacromolecules"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1021\/cr300508p","volume":"114","author":"Li X. H.","year":"2014","journal-title":"Chem. Rev."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1039\/b909065g","volume":"39","author":"Feng X. L.","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1021\/nn405923b","volume":"8","author":"Jiang B. P.","year":"2014","journal-title":"ACS Nano"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1002\/chem.200600514","volume":"13","author":"Zhang G. Q.","year":"2007","journal-title":"Chem.\u2014Eur. J."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"14410","DOI":"10.1021\/ja0269082","volume":"124","author":"An B. K.","year":"2002","journal-title":"J. Am. Chem. Soc."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1039\/b105159h","author":"Luo J. D.","year":"2001","journal-title":"Chem. Commun."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1039\/c1cs15113d","volume":"40","author":"Hong Y. N.","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1039\/b904665h","author":"Hong Y. N.","year":"2009","journal-title":"Chem. Commun."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1021\/ar3003464","volume":"46","author":"Ding D.","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.2174\/138527210793351571","volume":"14","author":"Zhao Z. J.","year":"2010","journal-title":"Curr. Org. Chem."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1039\/c3py00586k","volume":"4","author":"Xie H. F.","year":"2013","journal-title":"Polym. Chem."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1039\/C1AN15874K","volume":"137","author":"Gu X. G.","year":"2012","journal-title":"Analyst"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/molehr\/gat032","volume":"19","author":"Marei W. F. A.","year":"2013","journal-title":"Mol. Hum. Reprod."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.semcancer.2008.03.017","volume":"18","author":"Stern R.","year":"2008","journal-title":"Semin. Cancer Biol."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1021\/bm101451k","volume":"12","author":"Choh S. Y.","year":"2011","journal-title":"Biomacromolecules"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.ab.2003.08.005","volume":"322","author":"Takahashi T.","year":"2003","journal-title":"Anal. Biochem."}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bm500890d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T01:27:30Z","timestamp":1681608450000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bm500890d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,5]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9,8]]}},"alternative-id":["10.1021\/bm500890d"],"URL":"https:\/\/doi.org\/10.1021\/bm500890d","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,5]]}}}