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Sci."},{"key":"ref22\/cit22","first-page":"504","volume":"92","author":"Carr D. A.","year":"2009","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"11991","DOI":"10.1021\/ie1008025","volume":"49","author":"Carr D. A.","year":"2010","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"5933","DOI":"10.1039\/c2cs35103j","volume":"41","author":"Hu J.","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biomaterials.2006.08.047","volume":"28","author":"Torres M. P.","year":"2007","journal-title":"Biomaterials"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/jbm.b.31478","volume":"91","author":"Lopac S. K.","year":"2009","journal-title":"J. Biomed Mater. 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Soc."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0142-9612(82)90004-7","volume":"3","author":"Ulbrich K.","year":"1982","journal-title":"Biomaterials"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1163\/156856289X00145","volume":"1","author":"Subr V.","year":"1990","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.drudis.2009.10.009","volume":"15","author":"Vlieghe P.","year":"2010","journal-title":"Drug Discovery Today"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jconrel.2012.07.026","volume":"162","author":"Wanakule P.","year":"2012","journal-title":"J. Controlled Release"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1002\/adma.200601784","volume":"19","author":"Thornton P. D.","year":"2007","journal-title":"Adv. Mater."},{"key":"ref37\/cit37","volume-title":"United States Pharmacopeia; USP 29: The National Formulary; NF 24: Reagents: Test Solutions","year":"2006"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jconrel.2006.03.005","volume":"112","author":"Yamagata T.","year":"2006","journal-title":"J. Controlled Release"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/pola.25845","volume":"50","author":"Klinger D.","year":"2012","journal-title":"J. Polym. Sci., Part A: Polym. Chem."},{"key":"ref40\/cit40","unstructured":"Yanes, O.; Villanueva, J.; Querol, E.; Aviles, F.Enzymatic measurements for the detection of trypsin and carboxypeptidase A inhibitory activity;http:\/\/www.nature.com\/protocolexchange\/protocols\/331."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","DOI":"10.1002\/047147875X","volume-title":"Principles of Polymerization","author":"Odian G.","year":"2004","edition":"4"},{"key":"ref42\/cit42","volume-title":"Polymer Handbook","author":"Brandup J.","year":"1989","edition":"3"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1021\/ma970399k","volume":"30","author":"Lowman A. M.","year":"1997","journal-title":"Macromolecules"},{"key":"ref44\/cit44","volume-title":"Bioconjugate Techniques","author":"Hermanson G. 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Pharm."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jconrel.2014.06.041","volume":"190","author":"Peppas N. A.","year":"2014","journal-title":"J. Controlled Release"},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0168-3659(91)90067-N","volume":"15","author":"Joshi A.","year":"1991","journal-title":"J. Controlled Release"},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1021\/bm060086+","volume":"7","author":"Rice M. A.","year":"2006","journal-title":"Biomacromolecules"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/gut.27.8.886","volume":"27","author":"Davis S. S.","year":"1986","journal-title":"Gut"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/0006-3002(55)90280-8","volume":"16","author":"Schwert G. W.","year":"1955","journal-title":"Biochim. Biophys. 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