{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:48:55Z","timestamp":1768978135159,"version":"3.49.0"},"reference-count":50,"publisher":"American Chemical Society (ACS)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2011,6,17]]},"DOI":"10.1021\/cb100411v","type":"journal-article","created":{"date-parts":[[2011,3,4]],"date-time":"2011-03-04T20:21:26Z","timestamp":1299270086000},"page":"609-617","source":"Crossref","is-referenced-by-count":30,"title":["Mapping the Pro-Peptide of the <i>Schistosoma mansoni<\/i> Cathepsin B1 Drug Target: Modulation of Inhibition by Heparin and Design of Mimetic Inhibitors"],"prefix":"10.1021","volume":"6","author":[{"given":"Martin","family":"Horn","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad\u00e9la","family":"J\u00edlkov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610 Prague, Czech Republic"},{"name":"Department of Biochemistry, Faculty of Science, Charles University in Prague, Hlavova 8, 12843 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Vondr\u00e1\u0161ek","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Mare\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor R.","family":"Caffrey","sequence":"additional","affiliation":[{"name":"Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences (QB3), University of California San Francisco, 1700 Fourth Street, San Francisco, California 94158, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mare\u0161","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2011,3,17]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2010.08.020"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","volume":"368","author":"Gryseels B.","year":"2006","journal-title":"Lancet"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cbpa.2007.05.031","volume":"11","author":"Caffrey C. R.","year":"2007","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"39316","DOI":"10.1074\/jbc.M607128200","volume":"281","author":"Delcroix M.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pt.2004.03.004","volume":"20","author":"Caffrey C. R.","year":"2004","journal-title":"Trends Parasitol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"e449","DOI":"10.1371\/journal.pntd.0000449","volume":"3","author":"Dvo\u0159\u00e1k J.","year":"2009","journal-title":"PLoS Neglected Trop. Dis."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0166-6851(03)00194-4","volume":"131","author":"Sajid M.","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/abbi.2000.1905","volume":"380","author":"Brady C. P.","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1017\/S0031182098003746","volume":"118","author":"Hola-Jamriska L.","year":"1999","journal-title":"Parasitology"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0014-5793(99)01798-6","volume":"466","author":"Caffrey C. R.","year":"2000","journal-title":"FEBS Lett."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0166-6851(00)00351-0","volume":"112","author":"Brindley P. J.","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"35950","DOI":"10.1074\/jbc.M405842200","volume":"279","author":"Williamson A. L.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref13\/cit13","first-page":"275","volume":"295","author":"Goldberg D. E.","year":"2005","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1756-3305-1-7","volume":"1","author":"Sojka D.","year":"2008","journal-title":"Parasit. Vectors"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.chembiol.2009.09.009","volume":"16","author":"Horn M.","year":"2009","journal-title":"Chem. Biol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1371\/journal.pmed.0040014","volume":"4","author":"Abdulla M. H.","year":"2007","journal-title":"PLoS. Med."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"D227","DOI":"10.1093\/nar\/gkp971","volume":"38","author":"Rawlings N. D.","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"13036","DOI":"10.1016\/S0021-9258(18)99980-1","volume":"269","author":"Mach L.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2174\/1389203024605331","volume":"3","author":"Yamamoto Y.","year":"2002","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/1389203033487081","volume":"4","author":"Wiederanders B.","year":"2003","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0166-6851(98)00164-9","volume":"98","author":"Roche L.","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/j.1742-4658.2007.05666.x","volume":"274","author":"Reis F. C.","year":"2007","journal-title":"FEBS J."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"12571","DOI":"10.1021\/bi00165a005","volume":"31","author":"Fox T.","year":"1992","journal-title":"Biochemistry"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0014-5793(96)00822-8","volume":"392","author":"Chagas J. R.","year":"1996","journal-title":"FEBS Lett."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"25112","DOI":"10.1074\/jbc.273.39.25112","volume":"273","author":"Lalmanach G.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1515\/BC.2005.109","volume":"386","author":"Horn M.","year":"2005","journal-title":"Biol. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"e5694","DOI":"10.1371\/journal.pone.0005694","volume":"4","author":"Pandey K. C.","year":"2009","journal-title":"PLoS One"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1021\/jm070735f","volume":"51","author":"Korde R.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0969-2126(96)00046-9","volume":"4","author":"Cygler M.","year":"1996","journal-title":"Structure"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-5793(96)00309-2","volume":"384","author":"Turk D.","year":"1996","journal-title":"FEBS Lett."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1021\/jm020238t","volume":"45","author":"Chowdhury S. F.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"28669","DOI":"10.1074\/jbc.M204004200","volume":"277","author":"Li Z.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1074\/jbc.M003820200","volume":"276","author":"Almeida P. C.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"33076","DOI":"10.1074\/jbc.M705761200","volume":"282","author":"Caglic D.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.febslet.2004.12.093","volume":"579","author":"Vasiljeva O.","year":"2005","journal-title":"FEBS Lett."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.bbrc.2007.12.062","volume":"366","author":"Fairhead M.","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/01.ATV.9.1.21","volume":"9","author":"Cardin A. D.","year":"1989","journal-title":"Arteriosclerosis"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-6851(02)00022-1","volume":"121","author":"Caffrey C. R.","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1747-0285.2008.00741.x","volume":"72","author":"Gandhi N. S.","year":"2008","journal-title":"Chem. Biol. Drug Des."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1021\/ac100188x","volume":"82","author":"Uniewicz K. A.","year":"2010","journal-title":"Anal. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1021\/bi048135v","volume":"44","author":"Matulis D.","year":"2005","journal-title":"Biochemistry"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1017\/S0022149X00015832","volume":"71","author":"Hamed R. R.","year":"1997","journal-title":"J. Helminthol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"12824","DOI":"10.1074\/jbc.M513331200","volume":"281","author":"Choe Y.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/oxfordjournals.jbchem.a022651","volume":"127","author":"Yamamoto A.","year":"2000","journal-title":"J. Biochem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-5793(82)80210-X","volume":"142","author":"Pohl J.","year":"1982","journal-title":"FEBS Lett."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.chembiol.2005.10.005","volume":"12","author":"Dole\u010dkov\u00e1-Mare\u0161ov\u00e1 L.","year":"2005","journal-title":"Chem. Biol."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1016\/0006-2952(73)90196-2","volume":"22","author":"Cheng Y.","year":"1973","journal-title":"Biochem. Pharmacol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"15474","DOI":"10.1021\/bi0614986","volume":"45","author":"M\u00e1\u0161a M.","year":"2006","journal-title":"Biochemistry"},{"key":"ref49\/cit49","unstructured":"MOE: Chemical Computing Group, 1010 Sherbrooke St.West, Suite 910, Montreal, Canada H3A 2R7;http:\/\/www.chemcomp.com."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1002\/jcc.20933","volume":"29","author":"Labute P.","year":"2008","journal-title":"J. Comput. Chem."}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cb100411v","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:01:48Z","timestamp":1681516908000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cb100411v"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,17]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6,17]]}},"alternative-id":["10.1021\/cb100411v"],"URL":"https:\/\/doi.org\/10.1021\/cb100411v","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,17]]}}}