{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:14:44Z","timestamp":1789784084408,"version":"4.0.1"},"reference-count":77,"publisher":"American Chemical Society (ACS)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2013,4,19]]},"DOI":"10.1021\/cb300555n","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T17:18:05Z","timestamp":1358961485000},"page":"812-822","source":"Crossref","is-referenced-by-count":26,"title":["Identification of Novel Host-Targeted Compounds That Protect from Anthrax Lethal Toxin-Induced Cell Death"],"prefix":"10.1021","volume":"8","author":[{"given":"Louise H.","family":"Slater","sequence":"first","affiliation":[{"name":"Department of Molecular Biology\rand Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street,\rBoston, Massachusetts 02114, United States"},{"name":"Infectious Disease Initiative, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts\r02142, United States"},{"name":"Department\rof Microbiology and\rImmunobiology, Harvard Medical School,\r77 Ave. Louis Pasteur Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik C.","family":"Hett","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology\rand Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street,\rBoston, Massachusetts 02114, United States"},{"name":"Infectious Disease Initiative, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts\r02142, United States"},{"name":"Department\rof Microbiology and\rImmunobiology, Harvard Medical School,\r77 Ave. Louis Pasteur Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Mark","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology\rand Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street,\rBoston, Massachusetts 02114, United States"},{"name":"Infectious Disease Initiative, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts\r02142, United States"},{"name":"Department\rof Microbiology and\rImmunobiology, Harvard Medical School,\r77 Ave. Louis Pasteur Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Chumbler","sequence":"additional","affiliation":[{"name":"Department of Microbiology and\rImmunology, Vanderbilt University Medical Center, A-5301 Medical Center North, 1161 21st Avenue South, Nashville,\rTennessee 37232, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Patel","sequence":"additional","affiliation":[{"name":"Department\rof Microbiology and\rImmunobiology, Harvard Medical School,\r77 Ave. Louis Pasteur Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Borden","family":"Lacy","sequence":"additional","affiliation":[{"name":"Department of Microbiology and\rImmunology, Vanderbilt University Medical Center, A-5301 Medical Center North, 1161 21st Avenue South, Nashville,\rTennessee 37232, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. John","family":"Collier","sequence":"additional","affiliation":[{"name":"Department\rof Microbiology and\rImmunobiology, Harvard Medical School,\r77 Ave. Louis Pasteur Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah T.","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology\rand Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street,\rBoston, Massachusetts 02114, United States"},{"name":"Infectious Disease Initiative, Broad Institute, 7 Cambridge Center, Cambridge, Massachusetts\r02142, United States"},{"name":"Department\rof Microbiology and\rImmunobiology, Harvard Medical School,\r77 Ave. Louis Pasteur Boston, Massachusetts 02115, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,2,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.mam.2009.06.003","volume":"30","author":"Collier R. J.","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.280.5364.734","volume":"280","author":"Duesbery N. S.","year":"1998","journal-title":"Science"},{"issue":"3","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1042\/bj3520739","volume":"352","author":"Vitale G.","year":"2000","journal-title":"Biochem. J."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.1998.9040","volume":"248","author":"Vitale G.","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"e1002638","DOI":"10.1371\/journal.ppat.1002638","volume":"8","author":"Levinsohn J. L.","year":"2012","journal-title":"PLoS Pathog."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1073\/pnas.79.10.3162","volume":"79","author":"Leppla S. H.","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng1724","volume":"38","author":"Boyden E. D.","year":"2006","journal-title":"Nat. Genet."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"4312","DOI":"10.1073\/pnas.0707370105","volume":"105","author":"Fink S. L.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"758","DOI":"10.4161\/cc.6.6.3991","volume":"6","author":"Muehlbauer S. M.","year":"2007","journal-title":"Cell Cycle"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1128\/iai.51.3.795-800.1986","volume":"51","author":"Welkos S. L.","year":"1986","journal-title":"Infect. Immun."},{"key":"ref11\/cit11","first-page":"49","volume":"26","author":"Stanley J. L.","year":"1961","journal-title":"J. Gen. Microbiol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.micpath.2011.10.002","volume":"52","author":"Levy H.","year":"2012","journal-title":"Microb. Pathog."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1128\/IAI.06340-11","volume":"80","author":"Lovchik J. A.","year":"2012","journal-title":"Infect. Immun."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.mam.2009.08.007","volume":"30","author":"van der Goot G.","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nsmb.1923","volume":"17","author":"Feld G. K.","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1021\/bi015860m","volume":"41","author":"Mogridge J.","year":"2002","journal-title":"Biochemistry"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1083\/jcb.200312072","volume":"166","author":"Abrami L.","year":"2004","journal-title":"J. Cell Biol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1016\/S0021-9258(17)38364-3","volume":"261","author":"Friedlander A. M.","year":"1986","journal-title":"J. Biol. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"20607","DOI":"10.1016\/S0021-9258(17)32036-7","volume":"269","author":"Milne J. C.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2958.1993.tb00936.x","volume":"10","author":"Milne J. C.","year":"1993","journal-title":"Mol. Microbiol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1128\/AAC.01184-06","volume":"51","author":"Sanchez A. M.","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.1016\/j.bmc.2009.05.054","volume":"17","author":"Zhu P. J.","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.chembiol.2007.01.007","volume":"14","author":"Panchal R. G.","year":"2007","journal-title":"Chem. Biol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1073\/pnas.0812839106","volume":"106","author":"Fischer A.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"14095","DOI":"10.1021\/ja0457415","volume":"126","author":"Burke M. D.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1021\/bi00066a008","volume":"32","author":"Drose S.","year":"1993","journal-title":"Biochemistry"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.bbagen.2011.09.009","volume":"1820","author":"Mayle K. M.","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0014-4827(84)90699-2","volume":"150","author":"Geisow M. J.","year":"1984","journal-title":"Exp. Cell Res."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"8523","DOI":"10.1073\/pnas.82.24.8523","volume":"82","author":"Murphy R. F.","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1083\/jcb.200211018","volume":"160","author":"Abrami L.","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"e1000792","DOI":"10.1371\/journal.ppat.1000792","volume":"6","author":"Abrami L.","year":"2010","journal-title":"PLoS Pathog."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1083\/jcb.200507067","volume":"172","author":"Abrami L.","year":"2006","journal-title":"J. Cell Biol."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1073\/pnas.0910782107","volume":"107","author":"Abrami L.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref34\/cit34","first-page":"20","volume":"37","author":"Wang Wen-Lu W. Y.","year":"1994","journal-title":"Acta Entomol. Sin."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.2170\/jjphysiol.33.677","volume":"33","author":"Shih Y. L.","year":"1983","journal-title":"Jpn. J. Physiol."},{"key":"ref36\/cit36","first-page":"29","volume":"5","author":"Zou J.","year":"1985","journal-title":"J. Tradit. Chin. Med."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0014-5793(03)01291-2","volume":"555","author":"Zhou J. Y.","year":"2003","journal-title":"FEBS Lett."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1745-7254.2006.00236.x","volume":"27","author":"Li M. F.","year":"2006","journal-title":"Acta Pharmacol. Sin."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2011.06.012","volume":"10","author":"Sun S.","year":"2011","journal-title":"Cell Host Microbe"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2007.02.002","volume":"82","author":"Shi Y. L.","year":"2007","journal-title":"Prog. Neurobiol."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0168-0102(01)00233-4","volume":"40","author":"Wang Z. F.","year":"2001","journal-title":"Neurosci. Res."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0306-4522(01)00051-3","volume":"104","author":"Wang Z. F.","year":"2001","journal-title":"Neuroscience"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(01)01682-2","volume":"303","author":"Wang Z. F.","year":"2001","journal-title":"Neurosci. Lett."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ejphar.2004.08.027","volume":"501","author":"Li M. F.","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.neures.2004.02.012","volume":"49","author":"Li M. F.","year":"2004","journal-title":"Neurosci. Res."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1128\/AAC.01780-10","volume":"55","author":"Watanabe T.","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1128\/CMR.18.2.247-263.2005","volume":"18","author":"Voth D. E.","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"e10673","DOI":"10.1371\/journal.pone.0010673","volume":"5","author":"Papatheodorou P.","year":"2010","journal-title":"PLoS One"},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"34260","DOI":"10.1074\/jbc.M705687200","volume":"282","author":"Squires R. C.","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"6407","DOI":"10.1016\/j.bmc.2007.06.052","volume":"15","author":"Zheng C. H.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1021\/jm010016f","volume":"44","author":"Enyedy I. J.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/emboj\/17.4.1029","volume":"17","author":"Huang D. C.","year":"1998","journal-title":"EMBO J."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1074\/jbc.273.10.5841","volume":"273","author":"Pan G.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/cdd.2008.137","volume":"16","author":"Vogler M.","year":"2009","journal-title":"Cell Death Differ."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"10403","DOI":"10.1073\/pnas.96.18.10403","volume":"96","author":"Meng L.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1365-2958.1995.tb02375.x","volume":"15","author":"Milne J. C.","year":"1995","journal-title":"Mol. Microbiol."},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1002\/0471140864.ps0503s00"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"10432","DOI":"10.1021\/bi990792d","volume":"38","author":"Miller C. J.","year":"1999","journal-title":"Biochemistry"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"16756","DOI":"10.1073\/pnas.0405754101","volume":"101","author":"Zhang S.","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1128\/IAI.68.5.2470-2474.2000","volume":"68","author":"Qa\u2019Dan M.","year":"2000","journal-title":"Infect. Immun."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1006\/bbrc.1994.2815","volume":"205","author":"Muroi M.","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"33508","DOI":"10.1074\/jbc.273.50.33508","volume":"273","author":"Lyss G.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1073\/pnas.96.5.2227","volume":"96","author":"Kawakami Y.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/sj.onc.1210031","volume":"26","author":"Iwamaru A.","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1007\/BF01642906","volume":"238","author":"Mylecharane E. J.","year":"1991","journal-title":"J. Neurol."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"15771","DOI":"10.1016\/S0021-9258(18)98476-0","volume":"266","author":"Toullec D.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1158\/1078-0432.CCR-06-1330","volume":"12","author":"Duan Z.","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF01986567","volume":"33","author":"Hiyama Y.","year":"1991","journal-title":"Agents Actions"},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1046\/j.1471-4159.1995.65031054.x","volume":"65","author":"Alonso-Gomez A. L.","year":"1995","journal-title":"J. Neurochem."},{"key":"ref70\/cit70","first-page":"1270","volume":"63","author":"Blaskovich M. A.","year":"2003","journal-title":"Cancer Res."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.chembiol.2006.09.018","volume":"13","author":"Schust J.","year":"2006","journal-title":"Chem Biol"},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0009-2797(00)00225-8","volume":"130","author":"Lipsky J. J.","year":"2001","journal-title":"Chem. Biol. Interact."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1038\/sj.onc.1201790","volume":"16","author":"Sharma S. V.","year":"1998","journal-title":"Oncogene"},{"key":"ref74\/cit74","first-page":"6926","volume":"52","author":"Kwon H. J.","year":"1992","journal-title":"Cancer Res."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0305-0491(90)90194-X","volume":"97","author":"Kreuter M. H.","year":"1990","journal-title":"Comp. Biochem. Physiol. B"},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/0006-2952(93)90109-A","volume":"46","author":"Li Y. M.","year":"1993","journal-title":"Biochem. Pharmacol."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0014-5793(02)02738-2","volume":"519","author":"Marmy-Conus N.","year":"2002","journal-title":"FEBS Lett."}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cb300555n","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T08:44:59Z","timestamp":1682325899000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cb300555n"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,4]]},"references-count":77,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4,19]]}},"alternative-id":["10.1021\/cb300555n"],"URL":"https:\/\/doi.org\/10.1021\/cb300555n","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,4]]}}}