{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:23:48Z","timestamp":1773030228252,"version":"3.50.1"},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2013,9,20]]},"DOI":"10.1021\/cb400272m","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T02:44:08Z","timestamp":1373424248000},"page":"2033-2041","source":"Crossref","is-referenced-by-count":19,"title":["Development of Potent Fluorescent Polyamine Toxins and Application in Labeling of Ionotropic Glutamate Receptors in Hippocampal Neurons"],"prefix":"10.1021","volume":"8","author":[{"given":"Niels G.","family":"N\u00f8rager","sequence":"first","affiliation":[{"name":"Department of Drug Design and\rPharmacology, University of Copenhagen,\rUniversitetsparken 2, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel B.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and\rPharmacology, University of Copenhagen,\rUniversitetsparken 2, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Rathje","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and\rPharmacology, University of Copenhagen,\rBlegdamsvej 3B, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and\rPharmacology, University of Copenhagen,\rUniversitetsparken 2, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth L.","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and\rPharmacology, University of Copenhagen,\rBlegdamsvej 3B, DK-2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders S.","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Drug Design and\rPharmacology, University of Copenhagen,\rUniversitetsparken 2, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Str\u00f8mgaard","sequence":"additional","affiliation":[{"name":"Department of Drug Design and\rPharmacology, University of Copenhagen,\rUniversitetsparken 2, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2013,7,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/nmeth817","volume":"2","author":"Lichtman J.","year":"2005","journal-title":"Nat. Methods"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1039\/c0cc00686f","volume":"46","author":"Qian X.","year":"2010","journal-title":"Chem. Commun."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.drudis.2009.03.015","volume":"14","author":"Leopoldo M.","year":"2009","journal-title":"Drug Discov. Today"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1073\/pnas.0907915107","volume":"107","author":"Hern J. A.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1073\/pnas.1113761109","volume":"109","author":"Bach A.","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nmeth.1208","volume":"5","author":"Roy R.","year":"2008","journal-title":"Nat. Methods"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tips.2007.09.008","volume":"28","author":"Briddon S. J.","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ceb.2010.12.004","volume":"23","author":"Wu B.","year":"2011","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1021\/bi026576d","volume":"42","author":"Pick H.","year":"2003","journal-title":"Biochemistry"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1471-4159.2008.05336.x","volume":"106","author":"Daigle T. L.","year":"2008","journal-title":"J. Neurochem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nmeth.1213","volume":"5","author":"Maurel D.","year":"2008","journal-title":"Nat. Methods"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1478-811X-7-16","volume":"7","author":"Bohme I.","year":"2009","journal-title":"Cell Commun. Signal."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","volume":"62","author":"Traynelis S.","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nrn2379","volume":"9","author":"Pinheiro P. S.","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.tips.2011.08.003","volume":"32","author":"Ogden K.","year":"2011","journal-title":"Trends Pharmacol. Sci."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.1016\/j.bmc.2010.09.012","volume":"18","author":"Stawski P.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature08624","volume":"462","author":"Sobolevsky A.","year":"2009","journal-title":"Nature"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"10473","DOI":"10.1073\/pnas.0603225103","volume":"103","author":"Ramanoudjame G.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"15296","DOI":"10.1074\/jbc.M109.085035","volume":"285","author":"Rambhadran A.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.tins.2011.02.004","volume":"34","author":"Henley J. M.","year":"2011","journal-title":"Trends Neurosci."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1021\/bc100571g","volume":"23","author":"Marchand P.","year":"2011","journal-title":"Bioconjugate Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1016\/j.bmc.2011.05.034","volume":"19","author":"Joubert J.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bmc.2008.11.029","volume":"17","author":"Nishimaru T.","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"7151","DOI":"10.1039\/c1ob05963g","volume":"9","author":"Vytla D.","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.conb.2006.05.004","volume":"16","author":"Kwak S.","year":"2006","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.conb.2011.01.001","volume":"21","author":"Man H.-Y.","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(96)00042-X","volume":"717","author":"Green A.","year":"1996","journal-title":"Brain Res."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nature03819","volume":"436","author":"Posson D. J.","year":"2005","journal-title":"Nature"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"11296","DOI":"10.1002\/anie.201101599","volume":"50","author":"Olsen C. A.","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1002\/anie.200805426","volume":"48","author":"Nelson J. K.","year":"2009","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/jm301602d","volume":"56","author":"Poulsen M. H.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref32\/cit32","unstructured":"Briddon, S. J., Kellam, B., and Kill, S. J. (2011) InMethods in Molecular Biology: Receptor Signal Transduction Protocols(Willars, G. B. and Challiss, J., Eds.)3rded., Vol.746, pp211\u2013236,Springer Science-Business Media,New York."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/j.1476-5381.2009.00488.x","volume":"159","author":"Baker J. G.","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1021\/jm060606j","volume":"49","author":"Andersen T. F.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.cbpa.2011.10.013","volume":"15","author":"Wysocki L. M.","year":"2011","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref36\/cit36","volume-title":"Molecular Probes Handbook, A Guide to Fluorescent Probes and Labeling Technologies","author":"Johnson I.","year":"2010","edition":"11"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1021\/cr078381n","volume":"107","author":"Loudet A.","year":"2007","journal-title":"Chem. Rev."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1007\/s10812-008-9100-z","volume":"75","author":"Bryantseva N. G.","year":"2008","journal-title":"J. Appl. Spectrosc."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1021\/jo9706178","volume":"62","author":"Sun W.-C.","year":"1997","journal-title":"J. Org. Chem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1021\/ja974116f","volume":"120","author":"Jensen K. J.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"6046","DOI":"10.1016\/j.tet.2005.04.027","volume":"61","author":"Olsen C. A.","year":"2005","journal-title":"Tetrahedron"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/jo011148j","volume":"67","author":"Torn\u00f8e C. W.","year":"2002","journal-title":"J. Org. Chem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1039\/b616751a","volume":"5","author":"Bock V. D.","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/hc.520010507","volume":"1","author":"Shah M.","year":"1990","journal-title":"Heteroat. Chem."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1002\/anie.200400657","volume":"44","author":"Br\u00e4se S.","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"10814","DOI":"10.1021\/ja9823870","volume":"120","author":"Nicolaou K. C.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1021\/ja981812m","volume":"120","author":"Lee C. E.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1021\/ol701581g","volume":"9","author":"Goddard-Borger E. D.","year":"2007","journal-title":"Org. Lett."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1113\/jphysiol.1996.sp021674","volume":"496","author":"Burnashev N.","year":"1996","journal-title":"The J. Physiol."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/S0006-3495(95)80263-8","volume":"68","author":"Villarroel A.","year":"1995","journal-title":"Biophys. J."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0896-6273(02)00776-6","volume":"35","author":"Barria A.","year":"2002","journal-title":"Neuron"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cb400272m","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T21:07:23Z","timestamp":1681765643000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cb400272m"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,24]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9,20]]}},"alternative-id":["10.1021\/cb400272m"],"URL":"https:\/\/doi.org\/10.1021\/cb400272m","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,24]]}}}