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Soc."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.1021\/ja031580d","volume":"126","author":"Iwahara J.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature06684","volume":"452","author":"Parisien M.","year":"2008","journal-title":"Nature"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0022-2836(02)01243-3","volume":"325","author":"H\u00f6bartner C.","year":"2003","journal-title":"J. Mol. Biol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nature06389","volume":"450","author":"Zhang Q.","year":"2007","journal-title":"Nature"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"8972","DOI":"10.1021\/bi00449a003","volume":"28","author":"Kay L. 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G.","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.1093\/nar\/gkq1361","volume":"39","author":"Kloiber K.","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"13080","DOI":"10.1002\/anie.201207128","volume":"51","author":"Fauster K.","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1002\/pro.153","volume":"18","author":"Xue Y.","year":"2009","journal-title":"Protein Sci."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jmb.2004.02.031","volume":"338","author":"Pitt S. W.","year":"2004","journal-title":"J. Mol. Biol."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.sbi.2012.11.006","volume":"23","author":"Daubner G. M.","year":"2013","journal-title":"Curr. Opin. Struct. 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