{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:55:06Z","timestamp":1790718906492,"version":"4.1.0"},"reference-count":68,"publisher":"American Chemical Society (ACS)","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U54CA143869-01"],"award-info":[{"award-number":["1U54CA143869-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM079235"],"award-info":[{"award-number":["R01 GM079235"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005202","name":"Muscular Dystrophy Association","doi-asserted-by":"publisher","award":["254929"],"award-info":[{"award-number":["254929"]}],"id":[{"id":"10.13039\/100005202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2014,2,21]]},"DOI":"10.1021\/cb4007387","type":"journal-article","created":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T20:18:07Z","timestamp":1386620287000},"page":"538-550","source":"Crossref","is-referenced-by-count":71,"title":["Structure of the Myotonic Dystrophy Type 2 RNA and Designed Small Molecules That Reduce Toxicity"],"prefix":"10.1021","volume":"9","author":[{"given":"Jessica L.","family":"Childs-Disney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Yildirim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaJeung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy R.","family":"Lohman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirui","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Texas Medical Branch, 301 University Boulevard, Galveston, Texas 77555-0539, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Schatz","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Disney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,12,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1001\/jamainternmed.2013.6624","volume":"173","author":"Smith R. J.","year":"2013","journal-title":"JAMA Intern. Med."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2165\/00003088-200241040-00002","volume":"41","author":"Geary R. S.","year":"2002","journal-title":"Clin. Pharmacokinet."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1073\/pnas.1117019109","volume":"109","author":"Lee J. E.","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"13915","DOI":"10.1073\/pnas.0905780106","volume":"106","author":"Mulders S. A.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.1173110","volume":"325","author":"Wheeler T. M.","year":"2009","journal-title":"Science"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nature11362","volume":"488","author":"Wheeler T. M.","year":"2012","journal-title":"Nature"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.2174\/156802608786141133","volume":"8","author":"Alvarez-Salas L. M.","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"key":"ref8\/cit8","first-page":"47","volume":"209","author":"Lebleu B.","year":"1997","journal-title":"Ciba Found. Symp."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2174\/1389450043345137","volume":"5","author":"Nesterova M.","year":"2004","journal-title":"Curr. Drug Targets"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1021\/cr0681546","volume":"108","author":"Thomas J. R.","year":"2008","journal-title":"Chem. Rev."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1021\/cb200447r","volume":"7","author":"Guan L.","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/ar000118k","volume":"34","author":"Gallego J.","year":"2001","journal-title":"Acc. Chem. Res."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1126\/science.285.5434.1722","volume":"285","author":"Yoshizawa S.","year":"1999","journal-title":"Science"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/35030019","volume":"407","author":"Carter A. P.","year":"2000","journal-title":"Nature"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nsmb1271","volume":"14","author":"Borovinskaya M. A.","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/327389a0","volume":"327","author":"Moazed D.","year":"1987","journal-title":"Nature"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1021\/jm0255466","volume":"45","author":"Swayze E. E.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1021\/jm050815o","volume":"48","author":"Seth P. P.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s00702-010-0513-5","volume":"118","author":"Rogers J. T.","year":"2011","journal-title":"J. Neural Transm."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0166-3542(01)00222-4","volume":"54","author":"Chapman R. L.","year":"2002","journal-title":"Antiviral Res."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1385\/JMN:20:3:267","volume":"20","author":"Payton S.","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1021\/cb700174r","volume":"2","author":"Childs-Disney J. L.","year":"2007","journal-title":"ACS Chem. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"11185","DOI":"10.1021\/ja803234t","volume":"130","author":"Disney M. D.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/cbic.200600569","volume":"8","author":"Disney M. D.","year":"2007","journal-title":"ChemBioChem"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1126\/science.1062125","volume":"293","author":"Liquori C. L.","year":"2001","journal-title":"Science"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/hmg\/11.7.805","volume":"11","author":"Fardaei M.","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1093\/hmg\/10.19.2165","volume":"10","author":"Mankodi A.","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1021\/cb900025w","volume":"4","author":"Lee M. M.","year":"2009","journal-title":"ACS Chem. Biol."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"16068","DOI":"10.1073\/pnas.0901824106","volume":"106","author":"Arambula J. F.","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.chembiol.2010.12.020","volume":"18","author":"Daldrop P.","year":"2011","journal-title":"Chem. Biol."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nm.2374","volume":"17","author":"Fugier C.","year":"2011","journal-title":"Nat. Med."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/emboj.2010.21","volume":"29","author":"Sellier C.","year":"2010","journal-title":"EMBO J."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/cbic.201100487","volume":"13","author":"Fu Y.","year":"2012","journal-title":"ChemBioChem"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/nsmb.1519","volume":"15","author":"Teplova M.","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"8330","DOI":"10.1021\/bi300829w","volume":"51","author":"Coonrod L. A.","year":"2012","journal-title":"Biochemistry"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1006\/jmbi.1998.1789","volume":"279","author":"Ferre-D\u2019Amare A. R.","year":"1998","journal-title":"J. Mol. Biol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/353579a0","volume":"353","author":"Holbrook S. R.","year":"1991","journal-title":"Nature"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1073\/pnas.91.10.4160","volume":"91","author":"Cruse W. B.","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1006\/jmbi.2000.4338","volume":"305","author":"Schneider C.","year":"2001","journal-title":"J. Mol. Biol."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1021\/bi000018m","volume":"39","author":"Tanaka Y.","year":"2000","journal-title":"Biochemistry"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"12577","DOI":"10.1021\/bi9904508","volume":"38","author":"Anderson A. C.","year":"1999","journal-title":"Biochemistry"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"11959","DOI":"10.1021\/bi048973p","volume":"43","author":"Du Z.","year":"2004","journal-title":"Biochemistry"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.str.2004.01.014","volume":"12","author":"Ohlenschlager O.","year":"2004","journal-title":"Structure"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"9020","DOI":"10.1021\/jp8001614","volume":"112","author":"Joung I. S.","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen W. L.","year":"1983","journal-title":"J. Chem. Phys."},{"key":"ref46\/cit46","volume-title":"AMBER 11","author":"Case D. A.","year":"2010"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/ct900604a","volume":"6","author":"Yildirim I.","year":"2010","journal-title":"J. Chem. Theory Comput."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1529\/biophysj.106.097782","volume":"92","author":"Perez A.","year":"2007","journal-title":"Biophys. J."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/bioinformatics\/btm067","volume":"23","author":"Auffinger P.","year":"2007","journal-title":"Bioinformatics"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","volume":"25","author":"Wang J.","year":"2004","journal-title":"J. Comput. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1038\/ncomms3044","volume":"4","author":"Childs-Disney J. L.","year":"2013","journal-title":"Nat. Commun."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/jcc.21372","volume":"31","author":"Rastelli G.","year":"2010","journal-title":"J. Comput. Chem."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/S1367-5931(99)00028-9","volume":"3","author":"Walter F.","year":"1999","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1261\/rna.610607","volume":"13","author":"Warf M. B.","year":"2007","journal-title":"RNA"},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"16626","DOI":"10.1073\/pnas.0505873102","volume":"102","author":"Mooers B. H.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/cbic.200900716","volume":"11","author":"Disney M. D.","year":"2010","journal-title":"ChemBioChem"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"5677","DOI":"10.1093\/nar\/gki862","volume":"33","author":"Francois B.","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"8881","DOI":"10.1093\/nar\/gkr415","volume":"39","author":"Wong C. H.","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1039\/c1mb05074e","volume":"7","author":"Lee M. M.","year":"2011","journal-title":"Mol. Biosyst."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1021\/cb3001606","volume":"7","author":"Childs-Disney J. L.","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1038\/mtna.2013.9","volume":"2","author":"Gonzalez-Barriga A.","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"e24308","DOI":"10.1371\/journal.pone.0024308","volume":"6","author":"Evers M. M.","year":"2011","journal-title":"PLoS One"},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"10166","DOI":"10.1021\/bi101208k","volume":"49","author":"Gagnon K. T.","year":"2010","journal-title":"Biochemistry"},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1107\/S0907444903028956","volume":"60","author":"Storoni L. C.","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1107\/S0907444902016657","volume":"58","author":"Adams P. D.","year":"2002","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"ref66\/cit66","unstructured":"(2010) The PyMOL Molecular Graphics System, Version 1.3r1.Schr\u00f6dinger, LLC,Cambridge."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1093\/nar\/gkp608","volume":"37","author":"Lavery R.","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","volume":"98","author":"Baker N. A.","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cb4007387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T08:00:50Z","timestamp":1716278450000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cb4007387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,16]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2,21]]}},"alternative-id":["10.1021\/cb4007387"],"URL":"https:\/\/doi.org\/10.1021\/cb4007387","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,16]]}}}