{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:59:09Z","timestamp":1791464349948,"version":"4.3.4"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"2","license":[{"start":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T00:00:00Z","timestamp":1444953600000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01AI0358-01A1"],"award-info":[{"award-number":["1R01AI0358-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01AI090141-03"],"award-info":[{"award-number":["5R01AI090141-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32AI102567"],"award-info":[{"award-number":["F32AI102567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1054480"],"award-info":[{"award-number":["OPP1054480"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT078285"],"award-info":[{"award-number":["WT078285"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT096157"],"award-info":[{"award-number":["WT096157"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,2,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aminopyrazoles are a new class of antimalarial compounds identified in a cellular antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual stage parasites. To investigate their unknown mechanism of action and thus identify their target, we cultured parasites in the presence of a representative member of the aminopyrazole series, GNF-Pf4492, to select for resistance. Whole genome sequencing of three resistant lines showed that each had acquired independent mutations in a P-type cation-transporter ATPase, PfATP4 (PF3D7_1211900), a protein implicated as the novel Plasmodium spp. target of another, structurally unrelated, class of antimalarials called the spiroindolones and characterized as an important sodium transporter of the cell. Similarly to the spiroindolones, GNF-Pf4492 blocks parasite transmission to mosquitoes and disrupts intracellular sodium homeostasis. Our data demonstrate that PfATP4 plays a critical role in cellular processes, can be inhibited by two distinct antimalarial pharmacophores, and supports the recent observations that PfATP4 is a critical antimalarial target.<\/jats:p>","DOI":"10.1021\/cb500616x","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T15:06:56Z","timestamp":1413472016000},"page":"413-420","source":"Crossref","is-referenced-by-count":99,"title":["Mutations in the P-Type Cation-Transporter\nATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone\nAntimalarials"],"prefix":"10.1021","volume":"10","author":[{"given":"Erika L.","family":"Flannery","sequence":"first","affiliation":[{"name":"University of California San Diego School of Medicine , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Case W.","family":"McNamara","sequence":"additional","affiliation":[{"name":"The Genomics Institute of the Novartis Research Foundation , , ,","place":["San Diego, California, United States, 92121"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Wan","family":"Kim","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyo Sakata","family":"Kato","sequence":"additional","affiliation":[{"name":"The Genomics Institute of the Novartis Research Foundation , , ,","place":["San Diego, California, United States, 92121"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengwu","family":"Li","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine H.","family":"Teng","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Gagaring","sequence":"additional","affiliation":[{"name":"The Genomics Institute of the Novartis Research Foundation , , ,","place":["San Diego, California, United States, 92121"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micah J.","family":"Manary","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Barboa","sequence":"additional","affiliation":[{"name":"The Genomics Institute of the Novartis Research Foundation , , ,","place":["San Diego, California, United States, 92121"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Meister","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelli","family":"Kuhen","sequence":"additional","affiliation":[{"name":"The Genomics Institute of the Novartis Research Foundation , , ,","place":["San Diego, California, United States, 92121"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Vinetz","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab K.","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"The Genomics Institute of the Novartis Research Foundation , , ,","place":["San Diego, California, United States, 92121"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Winzeler","sequence":"additional","affiliation":[{"name":"University of California San Diego School of Medicine , , , ,","place":["La Jolla, California, United States, 92093"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"2026092909082459600_cit1","doi-asserted-by":"crossref","first-page":"9059","DOI":"10.1073\/pnas.0802982105","article-title":"In silico activity profiling reveals\nthe mechanism of action of antimalarials\ndiscovered in a high-throughput screen","volume":"105","author":"Plouffe","year":"2008","journal-title":"Proc.\nNatl. Acad. Sci. U.S.A."},{"key":"2026092909082459600_cit2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","article-title":"Thousands\nof chemical starting points for antimalarial\nlead identification","volume":"465","author":"Gamo","year":"2010","journal-title":"Nature"},{"key":"2026092909082459600_cit3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature09099","article-title":"Chemical genetics of Plasmodium falciparum","volume":"465","author":"Guiguemde","year":"2010","journal-title":"Nature"},{"key":"2026092909082459600_cit4","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1126\/science.1211936","article-title":"Imaging of Plasmodium liver stages to drive next-generation antimalarial\ndrug discovery","volume":"334","author":"Meister","year":"2011","journal-title":"Science"},{"key":"2026092909082459600_cit5","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.1193225","article-title":"Spiroindolones,\na potent compound class for the treatment of malaria","volume":"329","author":"Rottmann","year":"2010","journal-title":"Science"},{"key":"2026092909082459600_cit6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nature12782","article-title":"Targeting Plasmodium PI(4)K to eliminate malaria","volume":"504","author":"McNamara","year":"2013","journal-title":"Nature"},{"key":"2026092909082459600_cit7","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1021\/jm200592f","article-title":"Structure-guided\nlead optimization\nof triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors\nwith clinical candidate potential","volume":"54","author":"Coteron","year":"2011","journal-title":"J. Med. Chem."},{"key":"2026092909082459600_cit8","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1021\/jm3001373","article-title":"3,5-Diaryl-2-aminopyridines\nas a novel class of orally active antimalarials demonstrating single\ndose cure in mice and clinical candidate potential","volume":"55","author":"Younis","year":"2012","journal-title":"J. Med. Chem."},{"key":"2026092909082459600_cit9","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrd3480","article-title":"How were new medicines discovered?","volume":"10","author":"Swinney","year":"2011","journal-title":"Nat. Rev. Drug Discovery"},{"key":"2026092909082459600_cit10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrd2201","article-title":"Drugs for\nbad bugs: Confronting the challenges of antibacterial discovery","volume":"6","author":"Payne","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"key":"2026092909082459600_cit11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrmicro3138","article-title":"Antimalarial drug discovery\u2500Approaches\nand progress towards new medicines","volume":"11","author":"Flannery","year":"2013","journal-title":"Nat. Rev.\nMicrobiol."},{"key":"2026092909082459600_cit12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrd1416","article-title":"Antimalarial\ndrug discovery: Efficacy models for compound screening","volume":"3","author":"Fidock","year":"2004","journal-title":"Nat. Rev. Drug Discovery"},{"key":"2026092909082459600_cit13","doi-asserted-by":"crossref","first-page":"27458","DOI":"10.1074\/jbc.M502319200","article-title":"Uncovering the molecular mode of\naction of the antimalarial drug atovaquone using a bacterial system","volume":"280","author":"Mather","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2026092909082459600_cit14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35005132","article-title":"The structure\nof malaria pigment \u03b2-haematin","volume":"404","author":"Pagola","year":"2000","journal-title":"Nature"},{"key":"2026092909082459600_cit15","doi-asserted-by":"crossref","first-page":"35078","DOI":"10.1074\/jbc.M804990200","article-title":"Identification\nand\ncharacterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase","volume":"283","author":"Patel","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2026092909082459600_cit16","doi-asserted-by":"crossref","first-page":"16823","DOI":"10.1073\/pnas.1204556109","article-title":"Malarial dihydrofolate reductase\nas a paradigm for drug development against a resistance-compromised\ntarget","volume":"109","author":"Yuthavong","year":"2012","journal-title":"Proc. Natl. Acad. Sci. 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Mol.\nCell Biol."},{"key":"2026092909082459600_cit20","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.bbamem.2010.07.009","article-title":"Sodium or potassium efflux ATPase a fungal, bryophyte,\nand protozoal ATPase","volume":"1798","author":"Rodriguez-Navarro","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"2026092909082459600_cit21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2012.12.006","article-title":"Na(+) regulation\nin the malaria parasite Plasmodium falciparum involves\nthe cation ATPase PfATP4\nand is a target of the spiroindolone antimalarials","volume":"13","author":"Spillman","year":"2013","journal-title":"Cell Host Microbe"},{"key":"2026092909082459600_cit22","doi-asserted-by":"crossref","first-page":"5155","DOI":"10.1021\/jm100410f","article-title":"Spirotetrahydro \u03b2-carbolines\n(spiroindolones): A new class of potent and orally efficacious compounds\nfor the treatment of malaria","volume":"53","author":"Yeung","year":"2010","journal-title":"J. Med. Chem."},{"key":"2026092909082459600_cit23","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nrd3301","article-title":"Antimalarial\ndrugs: Speeding to a new lead","volume":"9","author":"Tse","year":"2010","journal-title":"Nat. Rev. Drug\nDiscovery"},{"key":"2026092909082459600_cit24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa1315860","article-title":"Spiroindolone KAE609\nfor falciparum\nand vivax malaria","volume":"371","author":"White","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2026092909082459600_cit25","doi-asserted-by":"crossref","first-page":"7761","DOI":"10.1021\/jm400325j","article-title":"Using genetic\nmethods to define the\ntargets of compounds with antimalarial activity","volume":"56","author":"Flannery","year":"2013","journal-title":"J. Med. Chem."},{"key":"2026092909082459600_cit26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.chom.2012.04.015","article-title":"Selective\nand specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin","volume":"11","author":"Hoepfner","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2026092909082459600_cit27","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1021\/cb200105d","article-title":"A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor","volume":"6","author":"Nam","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"2026092909082459600_cit28","doi-asserted-by":"crossref","first-page":"e1003293","DOI":"10.1371\/journal.pgen.1003293","article-title":"Mitotic\nevolution of Plasmodium falciparum shows a stable\ncore genome but recombination in antigen families","volume":"9","author":"Bopp","year":"2013","journal-title":"PLoS Genet."},{"key":"2026092909082459600_cit29","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0021-9258(18)63238-7","article-title":"Bongkrekic\nacid. An inhibitor of the adenine nucleotide\ntranslocase of mitochondria","volume":"245","author":"Henderson","year":"1970","journal-title":"J. Biol. Chem."},{"key":"2026092909082459600_cit30","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nmeth904","article-title":"Efficient site-specific\nintegration in Plasmodium falciparumchromosomes\nmediated by mycobacteriophage Bxb1 integrase","volume":"3","author":"Nkrumah","year":"2006","journal-title":"Nat. Methods"},{"key":"2026092909082459600_cit32","doi-asserted-by":"crossref","first-page":"e62906","DOI":"10.1371\/journal.pone.0062906","article-title":"The open access\nmalaria box: A drug discovery catalyst\nfor neglected diseases","volume":"8","author":"Spangenberg","year":"2013","journal-title":"PLoS One"},{"key":"2026092909082459600_cit33","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1128\/AAC.06377-11","article-title":"The spiroindolone drug candidate\nNITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector","volume":"56","author":"van Pelt-Koops","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"2026092909082459600_cit34","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/978-1-62703-026-7_40","article-title":"Assessing transmission blockade in Plasmodium spp","volume":"923","author":"Blagborough","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"2026092909082459600_cit35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20131007","article-title":"Membrane transport in the malaria\nparasite and its\nhost erythrocyte","volume":"457","author":"Kirk","year":"2014","journal-title":"Biochem. J."},{"key":"2026092909082459600_cit36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1152\/physrev.2001.81.2.495","article-title":"Membrane transport\nin the malaria-infected erythrocyte","volume":"81","author":"Kirk","year":"2001","journal-title":"Physiol\nRev."},{"key":"2026092909082459600_cit37","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1021\/jm300041e","article-title":"Imidazolopiperazines:\nLead optimization of the second-generation antimalarial agents","volume":"55","author":"Nagle","year":"2012","journal-title":"J. Med. Chem."},{"key":"2026092909082459600_cit38","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.chembiol.2012.01.004","article-title":"Global phenotypic screening for antimalarials","volume":"19","author":"Guiguemde","year":"2012","journal-title":"Chem. Biol."},{"key":"2026092909082459600_cit39","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/0006-2952(92)90213-3","article-title":"Site of action\nof the antimalarial hydroxynaphthoquinone,\n2-[trans-4-(4\u2032-chlorophenyl) cyclohexyl]-3-hydroxy-1,4-naphthoquinone\n(566C80)","volume":"43","author":"Fry","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"2026092909082459600_cit40","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1046\/j.1365-2958.1999.01515.x","article-title":"Resistance\nmutations reveal the atovaquone-binding domain of cytochrome b in\nmalaria parasites","volume":"33","author":"Srivastava","year":"1999","journal-title":"Mol. Microbiol."},{"key":"2026092909082459600_cit41","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.4155\/fmc.12.177","article-title":"Exploration\nof 4(1H)-pyridones as a novel family of potent antimalarial\ninhibitors of the plasmodial cytochrome bc1","volume":"4","author":"Bueno","year":"2012","journal-title":"Future Med. Chem."},{"key":"2026092909082459600_cit42","doi-asserted-by":"crossref","first-page":"177ra137","DOI":"10.1126\/scitranslmed.3005029","article-title":"Quinolone-3-diarylethers: A new class of antimalarial\ndrug","volume":"5","author":"Nilsen","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"2026092909082459600_cit43","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0140-6736(96)90671-6","article-title":"Atovaquone and proguanil for Plasmodium falciparum malaria","volume":"347","author":"Radloff","year":"1996","journal-title":"Lancet"},{"key":"2026092909082459600_cit44","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1749-6632.1997.tb52330.x","article-title":"The plasma membrane\nH(+)-ATPase of\nfungi. A candidate drug target?","volume":"834","author":"Perlin","year":"1997","journal-title":"Ann. N.Y. Acad.\nSci."},{"key":"2026092909082459600_cit45","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/ci100039k","article-title":"Structure-based\ndesign of novel small-molecule inhibitors of Plasmodium falciparum","volume":"50","author":"Kortagere","year":"2010","journal-title":"J. Chem. Inf. Model."},{"key":"2026092909082459600_cit46","doi-asserted-by":"crossref","first-page":"36968","DOI":"10.1074\/jbc.M112.379842","article-title":"Regulation\nof the Plasmodium motor complex: Phosphorylation\nof myosin A tail-interacting protein (MTIP) loosens its grip on MyoA","volume":"287","author":"Douse","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2026092909082459600_cit47","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jmb.2005.11.027","article-title":"The MTIP-myosin\nA complex in blood stage malaria parasites","volume":"355","author":"Green","year":"2006","journal-title":"J. Mol. Biol."},{"key":"2026092909082459600_cit48","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/expr.1997.4156","article-title":"Plasmodium falciparum: A simple, rapid\nmethod for detecting parasite clones in microtiter plates","volume":"86","author":"Goodyer","year":"1997","journal-title":"Exp. Parasitol."},{"key":"2026092909082459600_cit49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1471-2105-15-63","article-title":"Identification\nof pathogen genomic variants through an integrated pipeline","volume":"15","author":"Manary","year":"2014","journal-title":"BMC Bioinf."},{"key":"2026092909082459600_cit50","doi-asserted-by":"crossref","first-page":"e37179","DOI":"10.1371\/journal.pone.0037179","article-title":"Algae-produced\nPfs25 elicits antibodies that inhibit\nmalaria transmission","volume":"7","author":"Gregory","year":"2012","journal-title":"PLoS One"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cb500616x","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acbcct\/article-pdf\/10\/2\/413\/7922040\/cb500616x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acbcct\/article-pdf\/10\/2\/413\/7922040\/cb500616x.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:22:12Z","timestamp":1790688132000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acbcct\/article\/10\/2\/413\/776701\/Mutations-in-the-P-Type-Cation-Transporter-ATPase"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,16]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,10,16]]},"published-print":{"date-parts":[[2015,2,20]]}},"URL":"https:\/\/doi.org\/10.1021\/cb500616x","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,16]]}}}