{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:01:17Z","timestamp":1791036077245,"version":"4.1.0"},"reference-count":38,"publisher":"American Chemical Society (ACS)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2006,10,1]]},"DOI":"10.1021\/cb600238x","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T08:40:27Z","timestamp":1160815227000},"page":"594-600","source":"Crossref","is-referenced-by-count":91,"title":["Conjugating Berberine to a Multidrug Resistance Pump Inhibitor Creates an Effective Antimicrobial"],"prefix":"10.1021","volume":"1","author":[{"given":"Anthony R.","family":"Ball","sequence":"first","affiliation":[{"name":"Department of Biology and Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Casadei","sequence":"additional","affiliation":[{"name":"Department of Biology and Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siritron","family":"Samosorn","sequence":"additional","affiliation":[{"name":"Institute for Biomolecular Science and Department of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Bremner","sequence":"additional","affiliation":[{"name":"Institute for Biomolecular Science and Department of Chemistry, University of Wollongong, Wollongong, New South Wales 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick M.","family":"Ausubel","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence I.","family":"Moy","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, and Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Biology and Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2006,10,13]]},"reference":[{"key":"cb-2006-00238x-ref1\/cb-2006-00238x-ref1_1","unstructured":"Lewis, K. and Lomovskaya, O. (2002) inBacterial Resistance to Antimicrobials: Mechanisms, Genetics, Medical Practice and Public Health(Lewis, K., Salyers, A., Taber, H. and Wax, R., Eds.) pp61\u201390,Marcel Dekker,New York."},{"key":"cb-2006-00238x-ref2\/cb-2006-00238x-ref2_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jac\/49.1.25","volume":"49","author":"Levy S. B.","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"cb-2006-00238x-ref3\/cb-2006-00238x-ref3_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/00003495-200464020-00004","volume":"64","author":"Li X. Z.","year":"2004","journal-title":"Drugs"},{"key":"cb-2006-00238x-ref4\/cb-2006-00238x-ref4_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/jac\/dki171","volume":"56","author":"Poole K.","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"cb-2006-00238x-ref5\/cb-2006-00238x-ref5_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/scdb.2000.0246","volume":"12","author":"Saier M. H.","year":"2001","journal-title":"Semin. Cell Dev. Biol."},{"key":"cb-2006-00238x-ref6\/cb-2006-00238x-ref6_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0092-8674(86)90595-7","volume":"47","author":"Chen C. J.","year":"1986","journal-title":"Cell"},{"key":"cb-2006-00238x-ref7\/cb-2006-00238x-ref7_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/37.2.2463300","volume":"37","author":"Thiebaut F.","year":"1989","journal-title":"J. Histochem. Cytochem."},{"key":"cb-2006-00238x-ref8\/cb-2006-00238x-ref8_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0092-8674(94)90212-7","volume":"77","author":"Schinkel A. H.","year":"1994","journal-title":"Cell"},{"key":"cb-2006-00238x-ref9\/cb-2006-00238x-ref9_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrn1728","volume":"6","author":"Loscher W.","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"cb-2006-00238x-ref10\/cb-2006-00238x-ref10_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrc706","volume":"2","author":"Gottesman M. M.","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"cb-2006-00238x-ref11\/cb-2006-00238x-ref11_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/15216540212646","volume":"53","author":"Konings W. N.","year":"2002","journal-title":"IUBMB Life"},{"key":"cb-2006-00238x-ref12\/cb-2006-00238x-ref12_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2958.2000.01926.x","volume":"37","author":"Zgurskaya H. I.","year":"2000","journal-title":"Mol. Microbiol."},{"key":"cb-2006-00238x-ref13\/cb-2006-00238x-ref13_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1369-5274(00)00243-5","volume":"4","author":"Markham P. N.","year":"2001","journal-title":"Curr. Opin. Microbiol."},{"key":"cb-2006-00238x-ref14\/cb-2006-00238x-ref14_1","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1128\/JB.180.13.3477-3479.1998","volume":"180","author":"Paulsen I. T.","year":"1998","journal-title":"J. Bacteriol."},{"key":"cb-2006-00238x-ref15\/cb-2006-00238x-ref15_1","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1021\/bi00122a014","volume":"31","author":"Gros P.","year":"1992","journal-title":"Biochemistry"},{"key":"cb-2006-00238x-ref16\/cb-2006-00238x-ref16_1","first-page":"247","volume":"3","author":"Lewis K.","year":"2001","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"cb-2006-00238x-ref17\/cb-2006-00238x-ref17_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1126\/science.1083137","volume":"300","author":"Yu E. W.","year":"2003","journal-title":"Science"},{"key":"cb-2006-00238x-ref18\/cb-2006-00238x-ref18_1","doi-asserted-by":"crossref","first-page":"6602","DOI":"10.1073\/pnas.95.12.6602","volume":"95","author":"Hsieh P. C.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"cb-2006-00238x-ref19\/cb-2006-00238x-ref19_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/152165401317291183","volume":"52","author":"Severina I. I.","year":"2001","journal-title":"IUBMB Life Sci."},{"key":"cb-2006-00238x-ref20\/cb-2006-00238x-ref20_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1023\/A:1015584423358","volume":"24","author":"Lin J.","year":"2002","journal-title":"Biotechnol. Lett."},{"key":"cb-2006-00238x-ref21\/cb-2006-00238x-ref21_1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tibtech.2005.05.004","volume":"23","author":"Lewis K.","year":"2005","journal-title":"Trends Biotechnol."},{"key":"cb-2006-00238x-ref22\/cb-2006-00238x-ref22_1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1139\/m69-190","volume":"15","author":"Amin A. H.","year":"1969","journal-title":"Can. J. Microbiol."},{"key":"cb-2006-00238x-ref23\/cb-2006-00238x-ref23_1","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1093\/nar\/4.8.2697","volume":"4","author":"Davidson M. W.","year":"1977","journal-title":"Nucleic Acids Res."},{"key":"cb-2006-00238x-ref24\/cb-2006-00238x-ref24_1","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1073\/pnas.030540597","volume":"97","author":"Stermitz F. R.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"cb-2006-00238x-ref25\/cb-2006-00238x-ref25_1","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1128\/AAC.43.10.2404","volume":"43","author":"Markham P. N.","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"cb-2006-00238x-ref26\/cb-2006-00238x-ref26_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/AAC.45.1.105-116.2001","volume":"45","author":"Lomovskaya O.","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"cb-2006-00238x-ref27\/cb-2006-00238x-ref27_1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.bcp.2005.12.008","volume":"71","author":"Lomovskaya O.","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"cb-2006-00238x-ref28\/cb-2006-00238x-ref28_1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1071\/CH03054","volume":"56","author":"Bremner J.B.","year":"2003","journal-title":"Austr. J. Chem."},{"key":"cb-2006-00238x-ref29\/cb-2006-00238x-ref29_1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bmc.2005.09.019","volume":"14","author":"Samosorn S.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"cb-2006-00238x-ref30\/cb-2006-00238x-ref30_1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1128\/AAC.41.4.869","volume":"41","author":"Lynch C.","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"cb-2006-00238x-ref31\/cb-2006-00238x-ref31_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3201\/eid0402.980211","volume":"4","author":"Gilmore M. S.","year":"1998","journal-title":"Emerging Infect. Dis."},{"key":"cb-2006-00238x-ref32\/cb-2006-00238x-ref32_1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0924-8579(02)00162-0","volume":"20","author":"Price C. T.","year":"2002","journal-title":"Int. J. Antimicrob. Agents"},{"key":"cb-2006-00238x-ref33\/cb-2006-00238x-ref33_1","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1073\/pnas.191378698","volume":"98","author":"Garsin D. A.","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"cb-2006-00238x-ref34\/cb-2006-00238x-ref34_1","doi-asserted-by":"crossref","first-page":"10414","DOI":"10.1073\/pnas.0604055103","volume":"103","author":"Moy T. I.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"cb-2006-00238x-ref35\/cb-2006-00238x-ref35_1","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1128\/AAC.50.4.1402-1410.2006","volume":"50","author":"Tegos G. P.","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"cb-2006-00238x-ref36\/cb-2006-00238x-ref36_1","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1073\/pnas.92.8.3449","volume":"92","author":"Merrifield R. B.","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"cb-2006-00238x-ref37\/cb-2006-00238x-ref37_1","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1128\/AAC.41.12.2733","volume":"41","author":"Kaatz G. W.","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"cb-2006-00238x-ref38\/cb-2006-00238x-ref38_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1126\/science.1073759","volume":"297","author":"Kim D. H.","year":"2002","journal-title":"Science"}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cb600238x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T07:13:13Z","timestamp":1678777993000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cb600238x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,1]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,10,1]]}},"alternative-id":["10.1021\/cb600238x"],"URL":"https:\/\/doi.org\/10.1021\/cb600238x","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,1]]}}}