{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:46:27Z","timestamp":1791272787202,"version":"4.1.0"},"reference-count":27,"publisher":"American Chemical Society (ACS)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Biol."],"published-print":{"date-parts":[[2008,12,19]]},"DOI":"10.1021\/cb800176t","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T21:35:47Z","timestamp":1227562547000},"page":"765-775","source":"Crossref","is-referenced-by-count":124,"title":["Antiviral Compounds Discovered by Virtual Screening of Small\u2212Molecule Libraries against Dengue Virus E Protein"],"prefix":"10.1021","volume":"3","author":[{"given":"Zhigang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoora","family":"Khaliq","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Markey Center for Structural Biology and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Eun","family":"Suk","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmay","family":"Patkar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Markey Center for Structural Biology and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Markey Center for Structural Biology and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Markey Center for Structural Biology and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol Beth","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Molecular Pharmacology"},{"name":"Department of Biological Sciences, Markey Center for Structural Biology and Purdue Cancer Center, Purdue University, West Lafayette, Indiana 47907"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2008,11,24]]},"reference":[{"key":"ref1\/cit1","first-page":"991","volume-title":"Fields Virology","author":"Lindenbach B. D.","year":"2001"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1001\/jama.2007.31-a","volume":"299","author":"Morens D. M.","year":"2008","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1093\/emboj\/cdg270","volume":"22","author":"Zhang Y.","year":"2003","journal-title":"EMBO J."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0092-8674(02)00660-8","volume":"108","author":"Kuhn R. J.","year":"2002","journal-title":"Cell"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.str.2004.06.019","volume":"12","author":"Zhang Y.","year":"2004","journal-title":"Structure"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature02165","volume":"427","author":"Modis Y.","year":"2004","journal-title":"Nature (London, U.K.)"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1073\/pnas.0832193100","volume":"100","author":"Modis Y.","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nsb990","volume":"10","author":"Zhang W.","year":"2003","journal-title":"Nat. Struct. Biol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1128\/JVI.79.2.1223-1231.2005","volume":"79","author":"Modis Y.","year":"2005","journal-title":"J. Virol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/375291a0","volume":"375","author":"Rey F. A.","year":"1995","journal-title":"Nature (London, U.K.)"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1021\/jm00150a025","volume":"28","author":"Diana G. D.","year":"1985","journal-title":"J. Med. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jmb.2006.11.033","volume":"366","author":"Goncalves R. B.","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/jmbi.1995.0536","volume":"253","author":"Hadfield A. T.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"11061","DOI":"10.1128\/JVI.78.20.11061-11069.2004","volume":"78","author":"Zhang Y.","year":"2004","journal-title":"J. Virol."},{"key":"ref15\/cit15","first-page":"590","volume":"8","author":"Szymkowski D. E.","year":"2005","journal-title":"Curr. Opin. Drug Discovery Dev."},{"key":"ref16\/cit16","first-page":"354","volume":"9","author":"Vajda S.","year":"2006","journal-title":"Curr. Opin. Drug Discovery Dev."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"17253","DOI":"10.1021\/ja053973d","volume":"127","author":"Zhou Z.","year":"2005","journal-title":"J. Am. Chem. Soc."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/prot.20223","volume":"57","author":"Zhou Z.","year":"2004","journal-title":"Proteins: Struct., Funct., Bioinf."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"7529","DOI":"10.1073\/pnas.0408749102","volume":"102","author":"Li Y.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1110\/ps.8.11.2281","volume":"8","author":"Phelps D. K.","year":"1999","journal-title":"Protein Sci."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0006-3495(01)75999-1","volume":"80","author":"Speelman B.","year":"2001","journal-title":"Biophys. J."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0960-9822(00)00176-7","volume":"4","author":"Grant R. A.","year":"1994","journal-title":"Curr. Biol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1021\/jm0306430","volume":"47","author":"Friesner R. A.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","volume":"47","author":"Halgren T. A.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","volume":"49","author":"Friesner R. A.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1021\/ja9621760","volume":"118","author":"Jorgensen W. L.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.1021\/ja0100120","volume":"123","author":"Mayer M.","year":"2001","journal-title":"J. Am. Chem. Soc."}],"container-title":["ACS Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cb800176t","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T13:48:12Z","timestamp":1679406492000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cb800176t"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,24]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2008,12,19]]}},"alternative-id":["10.1021\/cb800176t"],"URL":"https:\/\/doi.org\/10.1021\/cb800176t","relation":{},"ISSN":["1554-8929","1554-8937"],"issn-type":[{"value":"1554-8929","type":"print"},{"value":"1554-8937","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,24]]}}}