{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:09:29Z","timestamp":1790251769701,"version":"4.1.0"},"reference-count":100,"publisher":"American Chemical Society (ACS)","issue":"9","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100021281","name":"Gates Family Foundation","doi-asserted-by":"publisher","award":["INV-051757"],"award-info":[{"award-number":["INV-051757"]}],"id":[{"id":"10.13039\/100021281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Succinic acid is an important industrial platform chemical with broad applications, and its sustainable production has become increasingly critical. Converting carbon dioxide (CO2) into succinic acid through integrated electrothermal catalytic routes offers a promising alternative to fossil-based and biological methods while contributing to carbon mitigation. This paper summarizes emerging pathways that utilize key CO2-electrocatalytic products, including gas-phase (C2H4\/CO\/H2), liquid-phase (acetic acid\/acetate), and gas\u2013liquid-phase (alcohols), as intermediates for thermocatalytic upgrading to succinic acid. By establishing a unified CO2 \u2192 intermediate \u2192 succinic acid reaction framework and evaluating the feasibility, conditions, and bottlenecks of each pathway. Among the proposed pathways, the C4 route via maleic anhydride shows the highest near-term feasibility, while gas\u2013liquid oxidative carbonylation offers strong integration potential. This work provides guidance for the development of sustainable, scalable CO2-based succinic acid production.<\/jats:p>","DOI":"10.1021\/cbe.6c00021","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:05:13Z","timestamp":1781103913000},"page":"765-779","source":"Crossref","is-referenced-by-count":0,"title":["Sustainable Production\nof Succinic Acid through CO2 Conversion"],"prefix":"10.1021","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2416-3546","authenticated-orcid":true,"given":"Miao","family":"Miao","sequence":"first","affiliation":[{"name":"North Carolina State University , , , ,","place":["Raleigh, North Carolina, United States, 27695"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8003-2358","authenticated-orcid":true,"given":"Zhaoxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Washington University in St. Louis , , , ,","place":["St. Louis, Missouri, United States, 63130"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"issue":"2","key":"2026092407080403000_cit1","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/fermentation3020026","article-title":"Succinic Acid: Technology Development\nand Commercialization","volume":"3","author":"Nghiem","year":"2017","journal-title":"Fermentation"},{"key":"2026092407080403000_cit2","doi-asserted-by":"publisher","first-page":"723412","DOI":"10.1155\/2013\/723412","article-title":"Fermentative succinate production: an emerging technology to replace\nthe traditional petrochemical processes","volume":"2013","author":"Cao","year":"2013","journal-title":"BioMed\nRes. 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Electrolysis for a Better Tomorrow. 2025. https:\/\/echemicles.com (accessed June 2, 2026)."},{"key":"2026092407080403000_cit35","unstructured":"FlowPhotoChem.\n          . Sustainable Chemicals with Sunlight and CO2. 2025. https:\/\/www.flowphotochem.eu (accessed June 2, 2026)."},{"key":"2026092407080403000_cit36","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.jechem.2023.11.019","article-title":"Electrocatalytic CO2 reduction to\nC2H4: From lab to fab","volume":"90","author":"Guo","year":"2024","journal-title":"J. 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Sci."},{"key":"2026092407080403000_cit46","doi-asserted-by":"publisher","first-page":"118471","DOI":"10.1016\/j.apcata.2021.118471","article-title":"Pd\/BN catalysts\nfor highly efficient hydrogenation of maleic anhydride to succinic\nanhydride","volume":"630","author":"Wang","year":"2022","journal-title":"Appl. Catal., A"},{"key":"2026092407080403000_cit47","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/B978-0-444-64046-8.00159-2","article-title":"Organic Acids:\nSuccinic and Malic Acids","volume-title":"Comprehensive Biotechnology","author":"Lee","year":"2019"},{"issue":"54","key":"2026092407080403000_cit48","doi-asserted-by":"publisher","first-page":"10907","DOI":"10.1039\/C5CC01932J","article-title":"Acrylate formation from CO2 and ethylene: catalysis with palladium and mechanistic insight","volume":"51","author":"Stieber","year":"2015","journal-title":"Chem. Commun. (Cambridge, U. 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Sci."},{"issue":"36","key":"2026092407080403000_cit61","doi-asserted-by":"publisher","first-page":"14093","DOI":"10.1021\/jacs.9b07310","article-title":"Cascade Reactions\nin Nanozymes: Spatially Separated Active Sites inside Ag-Core-Porous-Cu-Shell\nNanoparticles for Multistep Carbon Dioxide Reduction to Higher Organic\nMolecules","volume":"141","author":"O\u2019Mara","year":"2019","journal-title":"J. Am. Chem. Soc."},{"issue":"5","key":"2026092407080403000_cit62","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1021\/acssuschemeng.3c08139","article-title":"New Route of Acetylene\nSynthesis\nvia Electrochemical Formation of Metal Carbides from CO2 in Chloride Melts","volume":"12","author":"Suzuki","year":"2024","journal-title":"ACS Sustainable Chem. 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