{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:59:04Z","timestamp":1785473944177,"version":"3.56.0"},"reference-count":78,"publisher":"American Chemical Society (ACS)","issue":"7","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["ANRF\/ECRG\/2024\/001586\/LS"],"award-info":[{"award-number":["ANRF\/ECRG\/2024\/001586\/LS"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Unmet medical needs form the basis for the discovery of diagnostic tools and drugs for diseases that elude existing treatment options. Herein, we provide a perspective on the current trends in diagnosis and treatment using conventional and state-of-the-art diagnostic drugs. Our report highlights the evolution of diagnosis and therapy, more so in the form of after pulmonary combining the drug discovery process with diagnostics known as \u201cdrug-diagnostic codevelopment\u201d, which has opened the doors for precision medicine. Modern-age diagnostic drugs, such as conjugating a drug to fluorophores via a covalent bond, have the potential to both detect and treat diseases. However, fluorescence quenching in solutions is a major bottleneck. This can be addressed using quantum dots (QDs) conjugated to drugs such as cadmium telluride (CdTe) QDs conjugated to 5-fluorouracil (5-FU), naproxen, and celecoxib. However, these conjugates could get aggregated, and they may also pose health risks due to the involvement of heavy metals. Supramolecular chemistry could play a pivotal role in addressing both the aggregation and safety issues without compromising its utility. The discovery of supramolecular aggregation-induced emission (AIE) probes and their applications to drug conjugates have been demonstrated in a few studies. Taken together, this report summarizes the significance of advanced diagnostic drugs possessing AIE-conjugated probes for use in diagnosis and therapy.<\/jats:p>","DOI":"10.1021\/cbmi.5c00236","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T19:34:44Z","timestamp":1769801684000},"page":"1248-1257","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Drugs: Concept,\nCurrent Status, and Challenges\nin New-Age Diagnosis Platform Development"],"prefix":"10.1021","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-9322","authenticated-orcid":true,"given":"Suresh K.","family":"Kalangi","sequence":"first","affiliation":[{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226001"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8422-6941","authenticated-orcid":true,"given":"Rajesh S.","family":"Bhosale","sequence":"additional","affiliation":[{"name":"Ganpat University , , Ganpat Vidyanagar, Mehsana Gandhinagar Highway, SH73, Village Kherva, Dist. Mehsana , , ,","place":["Kherva, Gujarat, India, 384012"]},{"name":"Ganpat University , , Ganpat Vidyanagar, Mehsana Gandhinagar Highway, SH73, Village Kherva, Dist. Mehsana , , ,","place":["Kherva, Gujarat, India, 384012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejender S.","family":"Thakur","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR) , ,","place":["Ghaziabad, India, 201002"]},{"name":"CSIR-Central Drug Research Institute , , ,","place":["Lucknow, India, 226001"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"2026073100215568200_cit1","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.2147\/JMDH.S512254","article-title":"Diagnostic\nChallenges and Patient Safety: The Critical Role of Accuracy - A Systematic\nReview","volume":"18","author":"Alharbi","year":"2025","journal-title":"J Multidiscip Healthc"},{"issue":"1","key":"2026073100215568200_cit2","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1534\/genetics.117.203067","article-title":"Model Organisms Facilitate\nRare Disease Diagnosis and Therapeutic Research","volume":"207","author":"Wangler","year":"2017","journal-title":"Genetics"},{"issue":"10236","key":"2026073100215568200_cit3","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1016\/S0140-6736(20)30965-X","article-title":"Trial and\nerror","volume":"395","author":"Ofri","year":"2020","journal-title":"Lancet"},{"key":"2026073100215568200_cit4","doi-asserted-by":"crossref","first-page":"xi","DOI":"10.1163\/9789004436978","volume-title":"Practicing biomedicine\nat the Albert Schweitzer hospital 1913\u20131965: ideas and improvisations","author":"Zumthurm","year":"2020"},{"issue":"2","key":"2026073100215568200_cit5","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1586\/14737159.2016.1132163","article-title":"Drug-diagnostic co-development:\nchallenges and issues","volume":"16","author":"Shimazawa","year":"2016","journal-title":"Expert Rev Mol Diagn"},{"issue":"1","key":"2026073100215568200_cit6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/s12915-020-00891-4","article-title":"Adaptive,\ndiverse and de-centralized diagnostics are key to the future of outbreak\nresponse","volume":"18","author":"Matthews","year":"2020","journal-title":"BMC Biol."},{"key":"2026073100215568200_cit7","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.628144","article-title":"Drug Repurposing Strategy (DRS):\nEmerging Approach to Identify Potential Therapeutics for Treatment\nof Novel Coronavirus Infection","volume":"8","author":"Sahoo","year":"2021","journal-title":"Front Mol Biosci"},{"issue":"5","key":"2026073100215568200_cit8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1053\/j.semnuclmed.2019.07.001","article-title":"Design and Challenges\nof Radiopharmaceuticals","volume":"49","author":"Vermeulen","year":"2019","journal-title":"Semin Nucl Med"},{"key":"2026073100215568200_cit9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-24181-9_1","article-title":"Nanomedicine:\nThe Medicine of Tomorrow","volume-title":"Nanomedicine\nand Nanobiotechnology","author":"Logothetidis","year":"2012"},{"issue":"10","key":"2026073100215568200_cit10","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1021\/bc200151q","article-title":"Theranostics: Combining Imaging and Therapy","volume":"22","author":"Kelkar","year":"2011","journal-title":"Bioconjugate Chemistry"},{"key":"2026073100215568200_cit11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fonc.2014.00105","article-title":"Companion\ndiagnostics for targeted cancer drugs - clinical\nand regulatory aspects","volume":"4","author":"Olsen","year":"2014","journal-title":"Front. 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