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Exogenous contrast agents play a crucial role in enhancing the sensitivity and specificity of PAI. Among these contrast agents, the rare earth materials (REM) have garnered a lot of interest due to their near-infrared (NIR) absorption properties. REM established itself as a well-known entity in the field of bioimaging and therapy due to their optical, magnetic, and photothermal characteristics. The photoacoustic phenomenon of REM has the potential to emerge as a promising feature alongside its existing properties. The integration of the various REM as PAI exogenous contrast agents offers the potential for targeted imaging of specific biological structures or pathological conditions. In the present study, mechanisms behind the generation of acoustic signals are elucidated in detail, providing insights into the underlying principles of acoustic enhancements, in relation to the properties of contrast agents. The integration of rare earth contrast agents in various studies is highlighted, showcasing their potential for acoustic detection, multimodal imaging, and therapy. This review provides a comprehensive overview of recent advancements in utilizing rare earth contrast agents for enhancing PAI.<\/jats:p>","DOI":"10.1021\/cbmi.5c00280","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T10:55:17Z","timestamp":1774522517000},"page":"1629-1645","source":"Crossref","is-referenced-by-count":2,"title":["Harnessing Rare-Earth\nMaterials as Exogenous Contrast\nAgents for Enhanced Photoacoustic Imaging"],"prefix":"10.1021","volume":"4","author":[{"given":"Hendry","family":"Saju","sequence":"first","affiliation":[{"name":"Jain University , , Jain Global Campus , , ,","place":["Bangalore, Karnataka, India, 562112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"George","sequence":"additional","affiliation":[{"name":"Jain University , , Jain Global Campus , , ,","place":["Bangalore, Karnataka, India, 562112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3026-5784","authenticated-orcid":true,"given":"Swathi","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Indian Institute of Science , , C. 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Raman Avenue , , ,","place":["Bengaluru, Karnataka, India, 560012"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nisarga","family":"Ramesh","sequence":"additional","affiliation":[{"name":"Jain University , , Jain Global Campus , , ,","place":["Bangalore, Karnataka, India, 562112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tharun","family":"Jaikumar","sequence":"additional","affiliation":[{"name":"Jain University , , Jain Global Campus , , ,","place":["Bangalore, Karnataka, India, 562112"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"National Institute of Mental Health and Neuro Sciences , , , ,","place":["Bangalore, Karnataka, India, 560029"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9064-4111","authenticated-orcid":true,"given":"Jaiprakash N.","family":"Sangshetti","sequence":"additional","affiliation":[{"name":"Y. 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