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This Perspective highlights recent advances in chemical and biomedical imaging across macro-, micro-, and nanoscales, using representative examples published in Chemical and Biomedical Imaging (CBMI). At the macroscale, we discuss chemically selective MRI, including endogenous and exogenous CEST strategies, together with photoacoustic imaging as a hybrid modality with functional and chemical contrast. At the microscale, we consider fluorescence, label-free optical and vibrational imaging, and selected X-ray approaches that expand sensitivity, specificity, and temporal resolution in biological and materials systems. At the nanoscale, we highlight super-resolution fluorescence microscopy, single-molecule methods, tip-enhanced Raman spectroscopy, and correlative imaging strategies that resolve local heterogeneity and molecular organization. Across scales, a common theme emerges that advances in probes, contrast mechanisms, instrumentation, and sample handling are enabling chemically informed imaging that connects molecular specificity with biological context.<\/jats:p>","DOI":"10.1021\/cbmi.6c00066","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T02:59:06Z","timestamp":1776221946000},"page":"1876-1885","source":"Crossref","is-referenced-by-count":1,"title":["Imaging from Macro\nto Nanoscale: Multimodal Advances\nin Chemical and Biomedical Imaging"],"prefix":"10.1021","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4018-381X","authenticated-orcid":true,"given":"Rong","family":"Zhou","sequence":"first","affiliation":[{"name":"University of Pennsylvania , , , ,","place":["Philadelphia, Pennsylvania, United States, 19104"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-7661","authenticated-orcid":true,"given":"Peng","family":"Chen","sequence":"additional","affiliation":[{"name":"Cornell University , , , ,","place":["Ithaca, New York, United States, 14850"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5144-1015","authenticated-orcid":true,"given":"Neso","family":"Sojic","sequence":"additional","affiliation":[{"name":"University of Bordeaux , Bordeaux INP, ISM, UMR CNRS 5255 , ,","place":["Pessac, France, 33607"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"issue":"8","key":"2026092808065578200_cit1","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nmeth.1483","article-title":"Going deeper\nthan microscopy: the optical imaging frontier in biology","volume":"7","author":"Ntziachristos","year":"2010","journal-title":"Nat. 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