{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:27:02Z","timestamp":1791098822300,"version":"4.1.0"},"reference-count":74,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Comb. Chem."],"published-print":{"date-parts":[[2009,5,11]]},"DOI":"10.1021\/cc9000136","type":"journal-article","created":{"date-parts":[[2009,3,12]],"date-time":"2009-03-12T20:40:54Z","timestamp":1236890454000},"page":"403-409","source":"Crossref","is-referenced-by-count":49,"title":["Efficient Synthesis Of Arrays Of Amino Acid Derived Ugi Products With Subsequent Amidation"],"prefix":"10.1021","volume":"11","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"D\u00f6mling","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Drug Discovery Institute, Pittsburgh, PA 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2009,3,12]]},"reference":[{"key":"ref1\/cit1a","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1367-5931(00)00092-2","volume":"4","author":"Weber L.","year":"2000","journal-title":"Curr. Opin. Chem. Biol."},{"key":"ref1\/cit1b","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1021\/ar990095d","volume":"33","author":"Montgomery J.","year":"2000","journal-title":"Acc. Chem. Res."},{"key":"ref1\/cit1c","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/1521-3773(20000915)39:18<3168::AID-ANIE3168>3.0.CO;2-U","volume":"39","author":"D\u00f6mling A.","year":"2000","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref1\/cit1d","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1021\/cr0505728","volume":"106","author":"D\u00f6mling A.","year":"2006","journal-title":"Chem. Rev."},{"key":"ref1\/cit1e","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1002\/anie.200604743","volume":"46","author":"Mihovilovic","year":"2007","journal-title":"Angew. Chem. Int. Ed"},{"key":"ref1\/cit1f","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/qsar.200540190","volume":"25","author":"Mironov M. A.","year":"2006","journal-title":"QSAR Comb. Sci."},{"key":"ref1\/cit1g","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1002\/anie.200460548","volume":"44","author":"Diego J.","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref1\/cit1h","first-page":"7","volume":"495","author":"Simon C.","year":"2004","journal-title":"Eur. J. Org. Chem."},{"key":"ref1\/cit1i","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1055\/s-2003-40507","author":"Orru R. V. A.","year":"2003","journal-title":"Synthesis"},{"key":"ref1\/cit1j","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/qsar.200320001","volume":"22","author":"Kappe C. O.","year":"2003","journal-title":"QSAR Comb. Sci."},{"key":"ref1\/cit1k","first-page":"3","volume":"113","author":"Zhu J.","year":"2003","journal-title":"Eur. J. Org. Chem."},{"key":"ref1\/cit1l","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11030-008-9072-1","volume":"12","author":"Hulme C.","year":"2008","journal-title":"Mol. Divers."},{"key":"ref2\/cit2","first-page":"386","volume":"71","author":"Ugi I.","year":"1959","journal-title":"Angew. Chem."},{"key":"ref3\/cit3","first-page":"126","volume":"51","author":"Passerini M.","year":"1921","journal-title":"Gazz. Chim. Ital."},{"key":"ref4\/cit4","first-page":"419","volume":"57","author":"Van Leusen D.","year":"2003","journal-title":"Org. React. (N.Y.)"},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1039\/B713065A","volume":"6","author":"Bon R. S.","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1021\/jo050132g","volume":"70","author":"Bon R. S.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref5\/cit5c","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1021\/jo070840x","volume":"72","author":"Elders N.","year":"2007","journal-title":"J. Org. Chem."},{"key":"ref5\/cit5d","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1039\/B713065A","volume":"6","author":"Bon R. S.","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"ref6\/cit6","first-page":"424","author":"Heck S.","year":"2000","journal-title":"Synlett"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"7961","DOI":"10.1002\/anie.200502636","volume":"44","author":"EI Ka\u00efm L.","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/ange.19600720709","volume":"72","author":"Ugi I.","year":"1960","journal-title":"Angew. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1021\/cc7001777","volume":"10","author":"Shaabani A.","year":"2008","journal-title":"J. Comb. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1021\/cc700151m","volume":"10","author":"Zhang L.","year":"2008","journal-title":"J. Comb. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/cc800035z","volume":"10","author":"Rodri\u00ecguez-Borges J. E.","year":"2008","journal-title":"J. Comb. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1021\/cc8000635","volume":"10","author":"Shaabani A.","year":"2008","journal-title":"J. Comb. Chem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1016\/j.bmcl.2008.06.014","volume":"18","author":"Shaabani A.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1021\/cc800093q","volume":"10","author":"Litvinov Y. M.","year":"2008","journal-title":"J. Comb. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.1016\/j.tetlet.2008.06.067","volume":"49","author":"Thompson M. J.","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"7044","DOI":"10.1002\/anie.200802582","volume":"47","author":"Barluenga J.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1021\/cc800099r","volume":"10","author":"Shaabani A.","year":"2008","journal-title":"J. Comb. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1002\/ejoc.200800643","volume":"2008","author":"Beaumont S.","year":"2008","journal-title":"Eur. J. Org. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.tetlet.2008.10.118","volume":"50","author":"Huang X.","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"11115","DOI":"10.1016\/j.tet.2008.09.092","volume":"64","author":"Wan J.-P.","year":"2008","journal-title":"Tetrahedron"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1021\/jm060073e","volume":"49","author":"Borthwick A. D.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22a","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0040-4039(96)02303-9","volume":"38","author":"Short K. M.","year":"1997","journal-title":"Tetrahedron Lett."},{"key":"ref22\/cit22b","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1016\/S0040-4039(97)01265-3","volume":"38","author":"Harriman G. C. B.","year":"1997","journal-title":"Tetrahedron Lett."},{"key":"ref22\/cit22c","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1021\/jo982192a","volume":"64","author":"Zhang J.","year":"1999","journal-title":"J. Org. Chem."},{"key":"ref22\/cit22d","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1016\/S0040-4039(98)00428-6","volume":"39","author":"Hanusch-Kompa C.","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"ref22\/cit22e","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1055\/s-2004-825606","author":"Pirrung M. C.","year":"2004","journal-title":"Synlett"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/anie.199601731","volume":"35","author":"Demharter A.","year":"1996","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"11657","DOI":"10.1016\/0040-4020(96)00647-3","volume":"52","author":"Ugi I.","year":"1996","journal-title":"Tetrahedron"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.1016\/S0040-4039(98)01509-3","volume":"39","author":"Park S. J.","year":"1998","journal-title":"Tetrahedron Lett."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.5012\/bkcs.2002.23.9.1277","volume":"23","author":"Kim Y. B.","year":"2002","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1021\/jo0501137","volume":"70","author":"Sollis S. L.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref28\/cit28a","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1021\/ol016716w","volume":"3","author":"Kim Y. B.","year":"2001","journal-title":"Org. Lett."},{"key":"ref28\/cit28b","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1016\/j.bmcl.2006.05.031","volume":"16","author":"Ku I. W.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref29\/cit29a","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1021\/ol016716w","volume":"3","author":"Kim Y. B.","year":"2001","journal-title":"Org. Lett."},{"key":"ref29\/cit29b","doi-asserted-by":"crossref","first-page":"5244","DOI":"10.1016\/j.bmcl.2006.05.031","volume":"16","author":"Ku I. W.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3987\/COM-08-S(F)101","volume":"77","author":"Srivastava S.","year":"2009","journal-title":"Heterocycles"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-2003-43357","author":"Illgen K.","year":"2004","journal-title":"Synlett"},{"key":"ref32\/cit32a","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1016\/j.bmcl.2007.04.066","volume":"17","author":"D\u00f6mling A.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref32\/cit32b","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.bmcl.2006.10.040","volume":"17","author":"D\u00f6mling A.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref32\/cit32c","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/qsar.200540300","volume":"25","author":"Beck B.","year":"2006","journal-title":"QSAR Comb. Sci."},{"key":"ref32\/cit32d","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1016\/j.tetlet.2006.04.026","volume":"47","author":"D\u00f6mling A.","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"ref32\/cit32e","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.tetlet.2006.01.032","volume":"47","author":"D\u00f6mling A.","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"ref32\/cit32f","first-page":"109","volume":"99","author":"D\u00f6mling A.","year":"2007","journal-title":"Arkivoc"},{"key":"ref32\/cit32g","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1016\/j.bmcl.2008.05.096","volume":"18","author":"D\u00f6mling A.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref32\/cit32h","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/anie.199305631","volume":"32","author":"D\u00f6mling A.","year":"1993","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00253-006-0829-0","volume":"75","author":"Salinas Y.","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1021\/jo7025965","volume":"73","author":"Arimitsu S.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref35\/cit35","first-page":"210","volume":"208","author":"Lu C.","year":"2008","journal-title":"Chem. Commun."},{"key":"ref36\/cit36a","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2174\/157018008783406615","volume":"5","author":"Riggs R. M.","year":"2008","journal-title":"Lett. Drug Des. Discov."},{"key":"ref36\/cit36b","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/10426500600919207","volume":"182","author":"El-Azab A. S.","year":"2007","journal-title":"Phosphorus, Sulfur Silicon Relat. Elem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1021\/jm701159t","volume":"51","author":"Cosimelli B.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1021\/ja711349r","volume":"130","author":"Ohshima T.","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1021\/jo702495u","volume":"73","author":"Ohshima Petitjean A.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref40\/cit40a","doi-asserted-by":"crossref","first-page":"8943","DOI":"10.1016\/j.tetlet.2007.10.117","volume":"48","author":"Sherman D.","year":"2007","journal-title":"Tetrahedron Lett."},{"key":"ref40\/cit40b","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1016\/j.tet.2007.11.100","volume":"64","author":"Devine S. M.","year":"2008","journal-title":"Tetrahedron"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1021\/cc060068w","volume":"8","author":"D\u00f6mling A.","year":"2006","journal-title":"J. Comb. Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1016\/j.tetlet.2007.03.146","volume":"48","author":"Sabot C.","year":"2007","journal-title":"Tetrahedron Lett."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/B:MODI.0000006783.21086.0d","volume":"6","author":"Sung K.","year":"2003","journal-title":"Mol. Divers."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/BF00124456","volume":"9","author":"Gerber P. R.","year":"1995","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"ref45\/cit45","first-page":"1488\u221293","volume":"41","author":"Tetko I. V.","year":"2001","journal-title":"J. Chem. Inf. Comp. Sci."}],"container-title":["Journal of Combinatorial Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cc9000136","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T21:26:55Z","timestamp":1628371615000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cc9000136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,12]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,5,11]]}},"alternative-id":["10.1021\/cc9000136"],"URL":"https:\/\/doi.org\/10.1021\/cc9000136","relation":{},"ISSN":["1520-4766","1520-4774"],"issn-type":[{"value":"1520-4766","type":"print"},{"value":"1520-4774","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,12]]}}}