{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:57:16Z","timestamp":1772834236569,"version":"3.50.1"},"reference-count":28,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Neurosci."],"published-print":{"date-parts":[[2011,3,16]]},"DOI":"10.1021\/cn100090g","type":"journal-article","created":{"date-parts":[[2010,12,30]],"date-time":"2010-12-30T17:47:24Z","timestamp":1293731244000},"page":"151-159","source":"Crossref","is-referenced-by-count":13,"title":["Cysteine Thioesters as Myelin Proteolipid Protein Analogues to Examine the Role of Butyrylcholinesterase in Myelin Decompaction"],"prefix":"10.1021","volume":"2","author":[{"given":"Ian R.","family":"Pottie","sequence":"first","affiliation":[{"name":"Department of Chemistry, Mount Saint Vincent University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma A.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mount Saint Vincent University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle A.","family":"Blackman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mount Saint Vincent University, Halifax, Nova Scotia, Canada"},{"name":"Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Earl","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mount Saint Vincent University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sultan","family":"Darvesh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mount Saint Vincent University, Halifax, Nova Scotia, Canada"},{"name":"Department of Medicine (Neurology and Geriatric Medicine), Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2010,12,30]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJM200009283431307","volume":"343","author":"Noseworthy J. H.","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1056\/NEJMra052130","volume":"354","author":"Frohman E. M.","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.2174\/0929867054039026","volume":"12","author":"Tzakos A. G.","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1357-2725(01)00136-4","volume":"34","author":"Greer J. M.","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ng0896-422","volume":"13","author":"Gow A.","year":"1996","journal-title":"Nat. Genet."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1046\/j.1471-4159.2001.00116.x","volume":"76","author":"Bizzozero O. A.","year":"2001","journal-title":"J. Neurochem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/bmj.1.4714.1035","volume":"1","author":"Lumsden C. E.","year":"1951","journal-title":"Br. Med. J."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cbi.2010.01.037","volume":"187","author":"Darvesh S.","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"ref9\/cit9","volume-title":"The Biology of Cholinesterases","author":"Silver A.","year":"1974","edition":"1"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1016\/j.bmc.2006.02.021","volume":"14","author":"Darvesh S.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1210\/en.2004-0569","volume":"145","author":"De Vriese C.","year":"2004","journal-title":"Endocrinology"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0306-4522(01)00613-3","volume":"110","author":"Mesulam M.-M.","year":"2002","journal-title":"Neuroscience"},{"key":"ref13\/cit13","volume-title":"Butyrylcholinesterase: Its Function and Inhibitors","author":"Giacobini E.","year":"2003","edition":"1"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrn1035","volume":"4","author":"Darvesh S.","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1021\/jo00293a012","volume":"55","author":"Conchillo A.","year":"1990","journal-title":"J. Org. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00002093-200304000-00011","volume":"17","author":"Darvesh S.","year":"2003","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman G. L.","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1021\/j100821a018","volume":"65","author":"Holland J. M.","year":"1961","journal-title":"J. Phys. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/A:1010947205224","volume":"21","author":"Darvesh S.","year":"2001","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref20\/cit20","unstructured":"Wavefunction Inc. (2006) Spartan \u201906 for Windows and Linux: Tutorial and User\u2019s Guide, Wavefunction Inc. Irvine CA, USA and Japan Branch Office Chiyoda-Ku, Tokyo, Japan."},{"key":"ref21\/cit21","first-page":"14642","volume":"36","author":"Saxena A.","year":"1997","journal-title":"Neuroscience"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"41141","DOI":"10.1074\/jbc.M210241200","volume":"278","author":"Nicolet Y.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jneuroim.2008.06.018","volume":"203","author":"Nizri E.","year":"2008","journal-title":"J. Neuroimmunol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1212\/01.WNL.0000142989.09633.5A","volume":"63","author":"Krupp L. B.","year":"2004","journal-title":"Neurology"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1287\/inte.28.5.29","volume":"28","author":"Fylstra D.","year":"1998","journal-title":"Interfaces"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1023\/A:1023042418784","volume":"9","author":"Nenov I. P.","year":"2003","journal-title":"Reliab. Comput."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman H. M.","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref28\/cit28","unstructured":"DeLano, W. L. (2006) The PyMOL Molecular Graphics System, version 0.99rc6.DeLano Scientific,San Carlos, CA,http:\/\/www.pymol.org."}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cn100090g","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T16:34:22Z","timestamp":1680539662000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cn100090g"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,30]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3,16]]}},"alternative-id":["10.1021\/cn100090g"],"URL":"https:\/\/doi.org\/10.1021\/cn100090g","relation":{},"ISSN":["1948-7193","1948-7193"],"issn-type":[{"value":"1948-7193","type":"print"},{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,30]]}}}