{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:49:06Z","timestamp":1791294546766,"version":"4.1.0"},"reference-count":35,"publisher":"American Chemical Society (ACS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Neurosci."],"published-print":{"date-parts":[[2011,5,18]]},"DOI":"10.1021\/cn200011h","type":"journal-article","created":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T19:23:33Z","timestamp":1299871413000},"page":"242-248","source":"Crossref","is-referenced-by-count":28,"title":["Molecular Engineering of a Secreted, Highly Homogeneous, and Neurotoxic A\u03b2 Dimer"],"prefix":"10.1021","volume":"2","author":[{"given":"Andreas","family":"M\u00fcller-Schiffmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aksana","family":"Andreyeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm H. C.","family":"Horn","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Gottmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Korth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich","family":"Sticht","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2011,3,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","volume":"8","author":"Haass C.","year":"2007","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/0092-8674(93)90312-E","volume":"75","author":"Haass C.","year":"1993","journal-title":"Cell"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"13042","DOI":"10.1523\/JNEUROSCI.2362-09.2009","volume":"29","author":"Takami M.","year":"2009","journal-title":"J. Neurosci."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.283.12.1571","volume":"283","author":"Naslund J.","year":"2000","journal-title":"JAMA"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","volume":"46","author":"McLean C. A.","year":"1999","journal-title":"Ann. Neurol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nm1782","volume":"14","author":"Shankar G. M.","year":"2008","journal-title":"Nat. Med."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","volume":"30","author":"Terry R. D.","year":"1991","journal-title":"Ann. Neurol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1073\/pnas.95.11.6448","volume":"95","author":"Lambert M. P.","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/416535a","volume":"416","author":"Walsh D. M.","year":"2002","journal-title":"Nature"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature04533","volume":"440","author":"Lesne S.","year":"2006","journal-title":"Nature"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/j.1471-4159.2005.03407.x","volume":"95","author":"Barghorn S.","year":"2005","journal-title":"J. Neurochem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1523\/JNEUROSCI.1633-03.2004","volume":"24","author":"Wang Q.","year":"2004","journal-title":"J. Neurosci."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1126\/science.1105850","volume":"307","author":"Petkova A. T.","year":"2005","journal-title":"Science"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"15595","DOI":"10.1073\/pnas.1001740107","volume":"107","author":"Sandberg A.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1021\/bi100583x","volume":"49","author":"Yamaguchi T.","year":"2010","journal-title":"Biochemistry"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/sj.emboj.7601616","volume":"26","author":"Munter L. M.","year":"2007","journal-title":"EMBO J."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1021\/jp100023q","volume":"114","author":"Horn A. H.","year":"2010","journal-title":"J. Phys. Chem. B"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1529\/biophysj.106.090993","volume":"91","author":"Huet A.","year":"2006","journal-title":"Biophys. J."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1021\/bi802046n","volume":"48","author":"Yu L.","year":"2009","journal-title":"Biochemistry"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"21636","DOI":"10.1074\/jbc.M109.088005","volume":"285","author":"Munter L. M.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"14597","DOI":"10.1073\/pnas.1003026107","volume":"107","author":"Richter L.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"28943","DOI":"10.1074\/jbc.M109.038646","volume":"284","author":"Eggert S.","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.1002\/anie.201004437","volume":"49","author":"Muller-Schiffmann A.","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1523\/JNEUROSCI.4970-06.2007","volume":"27","author":"Shankar G. M.","year":"2007","journal-title":"J. Neurosci."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1021\/ja036813f","volume":"126","author":"Hou L.","year":"2004","journal-title":"J. Am. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/j.1471-4159.2008.05680.x","volume":"107","author":"Piacentini R.","year":"2008","journal-title":"J. Neurochem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/j.1471-4159.2010.06692.x","volume":"113","author":"Maiti P.","year":"2010","journal-title":"J. Neurochem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"17342","DOI":"10.1073\/pnas.0506723102","volume":"102","author":"L\u00fchrs T.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1074\/jbc.M508962200","volume":"281","author":"Olofsson A.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen W. L.","year":"1983","journal-title":"J. Chem. Phys."},{"key":"ref31\/cit31","unstructured":"Case, D. A., Darden, T. A., Cheatham, T. E., Simmerling, C. L., Wang, J., Duke, R. E., Luo, R., Merz, K. M., Pearlman, D. A., Crowley, M., Walker, R. C., Zhang, W., Wang, B., Hayik, S., Roitberg, A., Seabra, G., Wong, K. F., Paesani, F., Wu, X., Brozell, S., Tsui, V., Gohlke, H., Yang, L., Tan, C., Mongan, J., Hornak, V., Cui, G., Beroza, P., Mathews, D. H., Schafmeister, C., Ross, W. S., and Kollman, P. A. (2006) AMBER9,University of California,San Francisco."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1523\/JNEUROSCI.13-07-03136.1993","volume":"13","author":"Sisodia S. S.","year":"1993","journal-title":"J. Neurosci."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1523\/JNEUROSCI.1013-06.2006","volume":"26","author":"Jungling K.","year":"2006","journal-title":"J. Neurosci."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1476-5381.2010.00656.x","volume":"160","author":"Kurz C.","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"9564","DOI":"10.1074\/jbc.270.16.9564","volume":"270","author":"Podlisny M. B.","year":"1995","journal-title":"J. Biol. Chem."}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cn200011h","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T03:58:22Z","timestamp":1712289502000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cn200011h"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,18]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5,18]]}},"alternative-id":["10.1021\/cn200011h"],"URL":"https:\/\/doi.org\/10.1021\/cn200011h","relation":{},"ISSN":["1948-7193","1948-7193"],"issn-type":[{"value":"1948-7193","type":"print"},{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,18]]}}}