{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:11:26Z","timestamp":1773202286581,"version":"3.50.1"},"reference-count":33,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Neurosci."],"published-print":{"date-parts":[[2013,1,16]]},"DOI":"10.1021\/cn300166c","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T00:39:02Z","timestamp":1355186342000},"page":"43-47","source":"Crossref","is-referenced-by-count":23,"title":["Partial Agonism of 5-HT<sub>3<\/sub>Receptors: A Novel Approach to the Symptomatic Treatment of IBS-D"],"prefix":"10.1021","volume":"4","author":[{"given":"Nicholas A.","family":"Moore","sequence":"first","affiliation":[{"name":"Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce J.","family":"Sargent","sequence":"additional","affiliation":[{"name":"Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Manning","sequence":"additional","affiliation":[{"name":"Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Guzzo","sequence":"additional","affiliation":[{"name":"Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2012,12,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1124\/jpet.102.033175","volume":"302","author":"Burris K. D.","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.neuropharm.2006.10.016","volume":"52","author":"Rollema H.","year":"2007","journal-title":"Neuropharmacology"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coph.2011.02.005","volume":"11","author":"Spiller R. C.","year":"2011","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1517\/14728222.11.4.527","volume":"11","author":"Thompson A. J.","year":"2007","journal-title":"Expert Opin. Ther. Targets"},{"issue":"2","key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1046\/j.1365-2036.1999.00003.x-i2","volume":"13","author":"Humphrey P. P. A.","year":"1999","journal-title":"Aliment Pharmacol. Ther."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0031-6997(25)07372-7","volume":"6","author":"Erspamer V.","year":"1954","journal-title":"Pharmacol. Rev."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1053\/j.gastro.2004.03.013","volume":"126","author":"Coates M. D.","year":"2004","journal-title":"Gastroenterology"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1053\/j.gastro.2005.09.031","volume":"130","author":"Atkinson W.","year":"2006","journal-title":"Gastroenterology"},{"key":"ref9\/cit9","first-page":"1","volume":"2009","author":"WGO","year":"2009","journal-title":"Global Guidelines"},{"key":"ref10\/cit10","first-page":"378","volume":"8","author":"Rocha E Silva M.","year":"1953","journal-title":"Br. J. Pharmacol."},{"key":"ref11\/cit11","first-page":"323","volume":"12","author":"Gaddum J. H.","year":"1957","journal-title":"Br. J. Pharmacol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0028-3908(86)90207-8","volume":"25","author":"Bradley P. B.","year":"1986","journal-title":"Neuropharmacology"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.coph.2011.01.011","volume":"11","author":"Niesler B.","year":"2011","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1471-4159.2008.05775.x","volume":"108","author":"Holbrook J. D.","year":"2009","journal-title":"J. Neurochem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/cne.22525","volume":"519","author":"Kapeller J.","year":"2011","journal-title":"J. Comparative Neurol."},{"key":"ref16\/cit16","first-page":"50","volume-title":"Serotonin and the scientific basis of anti-emetic therapy","author":"Richardson B. P.","year":"1995"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1517\/13543784.9.1.147","volume":"9","author":"Camilleri M.","year":"2000","journal-title":"Expert Opin. Invest. Drugs"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1476-5381.1988.tb11542.x","volume":"94","author":"Butler A.","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"ref19\/cit19","first-page":"259P","volume":"104","author":"Kilpatrick G. J.","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1517\/13543784.14.2.185","volume":"14","author":"Chey W. D.","year":"2005","journal-title":"Expert Opin. Invest. Drugs"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cgh.2007.12.015","volume":"6","author":"Andresen V.","year":"2008","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1038\/ajg.2009.223","volume":"104","author":"Ford A. C.","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/ajg.2010.25","volume":"105","author":"Chang L.","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1365-2982.2006.00861.x","volume":"19","author":"Camilleri M.","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1365-2982.2007.00938.x","volume":"19","author":"Grundy D.","year":"2007","journal-title":"Neurogastroenterol. Motil."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1080\/00365520802240255","volume":"43","author":"Matsueda M. D.","year":"2008","journal-title":"Scand. J. Gastroenterol."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1365-2036.2007.03591.x","volume":"27","author":"Choung R. S.","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"6826","DOI":"10.1074\/jbc.M707571200","volume":"283","author":"Hu X.-Q.","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bcp.2006.08.010","volume":"73","author":"Hogg R. C.","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0006-8993(00)02526-9","volume":"873","author":"Whalen E. J.","year":"2000","journal-title":"Brain Res."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/j.bpj.2009.06.018","volume":"97","author":"Corradi J.","year":"2009","journal-title":"Biophys. J."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.bmcl.2010.11.080","volume":"21","author":"Manning D. D.","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","unstructured":"Manning, D., Wierschke, J., Barnes, N. M., and Moore, N. (2011) 5-HT3Receptor Partial Agonist Modulation, A Novel Approach to the Treatment of Diarrhea Predominant Irritable Bowel Syndrome (IBS-D). Digestive Disease Week 2011. See alsowww.amriglobal.com\/img\/document_files\/DDW%20poster_final.pdf.","DOI":"10.1016\/S0016-5085(11)62547-X"}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cn300166c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:57:28Z","timestamp":1745416648000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cn300166c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,24]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,16]]}},"alternative-id":["10.1021\/cn300166c"],"URL":"https:\/\/doi.org\/10.1021\/cn300166c","relation":{},"ISSN":["1948-7193","1948-7193"],"issn-type":[{"value":"1948-7193","type":"print"},{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,24]]}}}