{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:13:21Z","timestamp":1791414801404,"version":"4.3.3"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Neurosci."],"published-print":{"date-parts":[[2013,1,16]]},"DOI":"10.1021\/cn3001872","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T05:05:28Z","timestamp":1358312728000},"page":"16-21","source":"Crossref","is-referenced-by-count":52,"title":["Revisiting Serotonin Reuptake Inhibitors and the Therapeutic Potential of \u201cUptake-2\u201d in Psychiatric Disorders"],"prefix":"10.1021","volume":"4","author":[{"given":"Lynette C.","family":"Daws","sequence":"first","affiliation":[{"name":"Departments of \u2020Physiology, \u2021Psychiatry, and \u00a7Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Koek","sequence":"additional","affiliation":[{"name":"Departments of \u2020Physiology, \u2021Psychiatry, and \u00a7Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan C.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Departments of \u2020Physiology, \u2021Psychiatry, and \u00a7Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2013,1,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2165\/00019053-200725010-00003","volume":"25","author":"Donohue J. M.","year":"2007","journal-title":"Pharmacoeconomics"},{"key":"ref2\/cit2","unstructured":"World Health Report (2004) ."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pharmthera.2008.10.004","volume":"121","author":"Daws L. C.","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref4\/cit4","volume-title":"Neurobiology of Depression","author":"Altieri S. C.","year":"2012"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","volume":"274","author":"Lesch K. P.","year":"1996","journal-title":"Science"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/(SICI)1096-8628(19990205)88:1<83::AID-AJMG15>3.0.CO;2-0","volume":"88","author":"Greenberg B. D.","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pharmthera.2011.03.013","volume":"131","author":"Daws L. C.","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jneumeth.2004.05.017","volume":"140","author":"Mathews T. A.","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/sj.npp.1300476","volume":"29","author":"Shen H.-W.","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","volume":"301","author":"Caspi A.","year":"2003","journal-title":"Science"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1192\/bjp.bp.105.009522","volume":"188","author":"Wilhelm K.","year":"2006","journal-title":"Br. J. Psychiatry"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1038\/sj.mp.4001981","volume":"12","author":"Cervilla. J. A.","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1176\/appi.ajp.2010.09101452","volume":"167","author":"Caspi A.","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/01.ypg.0000107928.32051.11","volume":"14","author":"Lee M.-S.","year":"2004","journal-title":"Psychiatr. Genet."},{"key":"ref15\/cit15","first-page":"1046","volume":"29","author":"Rausch J. L.","year":"2005","journal-title":"Biol. Psychiatry"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.mp.4001926","volume":"12","author":"Serretti A.","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1176\/ps.2009.60.11.1446","volume":"60","author":"Laje G.","year":"2009","journal-title":"Psychiatr. Serv."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrn2284","volume":"9","author":"Murphy D. L.","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"ref19\/cit19","first-page":"1","volume-title":"Experimental Models in Serotonin Transporter Research","author":"Luellen B. A.","year":"2010"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s11095-007-9254-z","volume":"24","author":"Koepsell H.","year":"2007","journal-title":"Pharm. Res."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-3-642-14541-4_3","volume":"201","author":"Nies A. T.","year":"2011","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.brainres.2005.09.016","volume":"1063","author":"Feng N.","year":"2005","journal-title":"Brain Res."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0006-8993(02)02709-9","volume":"942","author":"Zhou F. C.","year":"2002","journal-title":"Brain Res."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuron.2005.02.010","volume":"46","author":"Zhou F.-M.","year":"2005","journal-title":"Neuron"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1046\/j.1471-4159.2003.01836.x","volume":"86","author":"Monta\u00f1ez S.","year":"2003","journal-title":"J. Neurochem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/jnr.10521","volume":"71","author":"Schmitt A.","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"6431","DOI":"10.1523\/JNEUROSCI.4050-05.2006","volume":"26","author":"Daws L. C.","year":"2006","journal-title":"J. Neurosci."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"18976","DOI":"10.1073\/pnas.0800466105","volume":"105","author":"Baganz N. L.","year":"2008","journal-title":"Proc. Nat. Acad. Sci. U.S.A."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1124\/jpet.110.170142","volume":"335","author":"Duan H.","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/syn.20929","volume":"65","author":"Hagan C. E.","year":"2011","journal-title":"Synapse"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainres.2010.02.044","volume":"1326","author":"Feng N.","year":"2010","journal-title":"Brain Res."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neulet.2005.03.014","volume":"382","author":"Kitaichi K.","year":"2005","journal-title":"Neurosci. Lett."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/mp.2011.87","volume":"17","author":"Bacq A.","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"ref34\/cit34","first-page":"63","volume-title":"Electrochemical Methods in Neuroscience, for Methods and New Frontiers in Neuroscience","author":"Daws L. C.","year":"2007"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1517\/13543784.16.9.1365","volume":"16","author":"Chen A.","year":"2007","journal-title":"Expert Opin. Invest. Drugs"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuron.2005.03.013","volume":"46","author":"Sulzer D.","year":"2005","journal-title":"Neuron"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1111\/j.1471-4159.2008.05506.x","volume":"106","author":"Vialou V.","year":"2008","journal-title":"J. Neurochem."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00702-009-0205-1","volume":"116","author":"Wultsch T.","year":"2009","journal-title":"J. Neural Transm."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/dna.1997.16.871","volume":"16","author":"Gorboulev V.","year":"1997","journal-title":"DNA Cell Biol."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"10408","DOI":"10.1074\/jbc.272.16.10408","volume":"272","author":"Gr\u00fcndemann D.","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"32776","DOI":"10.1074\/jbc.273.49.32776","volume":"273","author":"Wu X.","year":"1998","journal-title":"J. Biol. Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.neuropharm.2006.01.005","volume":"50","author":"Amphoux A.","year":"2006","journal-title":"Neuropharmacology"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.neuroscience.2007.01.072","volume":"146","author":"Dahlin A.","year":"2007","journal-title":"Neuroscience"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.neuroscience.2006.09.058","volume":"144","author":"Vialou V.","year":"2007","journal-title":"Neuroscience"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/cne.21921","volume":"512","author":"Gasser P. J.","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.1964.tb04118.x","volume":"239","author":"Bertler A.","year":"1964","journal-title":"Acta Physiol. Scand. Suppl."},{"key":"ref47\/cit47","first-page":"34","volume":"25","author":"Burgen A. S. V.","year":"1965","journal-title":"Br. J. Pharmacol."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1471-4159.1967.tb09548.x","volume":"14","author":"Lichtensteiger W.","year":"1967","journal-title":"J. Neurochem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.2042-7158.1967.tb08097.x","volume":"19","author":"Fuxe K.","year":"1967","journal-title":"J. Pharm. Pharmacol."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0278-5846(88)90004-8","volume":"12","author":"Butler J.","year":"1988","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/S0022-3565(25)28709-2","volume":"175","author":"Shaskan E. G.","year":"1970","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1176\/appi.ajp.161.5.909","volume":"16","author":"Schildkraut J. J.","year":"2004","journal-title":"Am. J. Psychiatry"}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cn3001872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T17:17:59Z","timestamp":1745947079000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/cn3001872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,16]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1,16]]}},"alternative-id":["10.1021\/cn3001872"],"URL":"https:\/\/doi.org\/10.1021\/cn3001872","relation":{},"ISSN":["1948-7193","1948-7193"],"issn-type":[{"value":"1948-7193","type":"print"},{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,16]]}}}