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Med."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0014-5793(98)01419-7","volume":"440","author":"El-Agnaf O. M. A.","year":"1998","journal-title":"FEBS Lett."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1074\/jbc.274.12.7619","volume":"274","author":"Giasson B. I.","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1073\/pnas.97.9.4897","volume":"97","author":"Serpell L. C.","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/pro.570","volume":"20","author":"Cho M. K.","year":"2011","journal-title":"Protein Sci."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0022-2836(02)00735-0","volume":"322","author":"Lashuel H. A.","year":"2002","journal-title":"J. Mol. 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