{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:06:26Z","timestamp":1792058786803,"version":"4.4.0"},"reference-count":45,"publisher":"American Chemical Society (ACS)","issue":"8","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":365,"URL":"https:\/\/pubs.acs.org\/page\/policy\/authorchoice_termsofuse.html"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We describe the rationale for and the synthesis of a new class of compounds utilizing a modular approach that are designed to mimic ascorbic acid and to inhibit 2-oxoglutarate-dependent hydroxylases. Preliminary characterization of one of these compounds indicates in vivo anticonvulsant activity (6 Hz mouse model) at nontoxic doses, inhibition of the 2-oxoglutarate-dependent hydroxylase FTO, and expected increase in cellular N6-methyladenosine. This compound is also able to modulate various microRNA, an interesting result in light of the recent view that modulation of microRNAs may be useful for the treatment of CNS disease.<\/jats:p>","DOI":"10.1021\/cn500042t","type":"journal-article","created":{"date-parts":[[2014,5,18]],"date-time":"2014-05-18T10:32:04Z","timestamp":1400409124000},"page":"658-665","source":"Crossref","is-referenced-by-count":126,"title":["Synthesis of a FTO Inhibitor with Anticonvulsant Activity"],"prefix":"10.1021","volume":"5","author":[{"given":"Guanqun","family":"Zheng","sequence":"first","affiliation":[{"name":"University of Chicago , , 929 E. 57th St. , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Cox","sequence":"additional","affiliation":[{"name":"Midwestern University , , 19555 N. 59th Ave. , , ,","place":["Glendale, Arizona, United States, 85308"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Tribbey","sequence":"additional","affiliation":[{"name":"Midwestern University , , 19555 N. 59th Ave. , , ,","place":["Glendale, Arizona, United States, 85308"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Z.","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Chicago , , 929 E. 57th St. , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Iacoban","sequence":"additional","affiliation":[{"name":"Midwestern University , , 19555 N. 59th Ave. , , ,","place":["Glendale, Arizona, United States, 85308"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Booher","sequence":"additional","affiliation":[{"name":"Kennesaw State University , , 1000 Chastain Rd. , Box 1203, , ,","place":["Kennesaw, Georgia, United States, 30144"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Kennesaw State University , , 1000 Chastain Rd. , Box 1203, , ,","place":["Kennesaw, Georgia, United States, 30144"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Fudan University , , 826 Zhangheng Rd. , ,","place":["Shanghai, P. R. China, 201203"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Bae","sequence":"additional","affiliation":[{"name":"Midwestern University , , 19555 N. 59th Ave. , , ,","place":["Glendale, Arizona, United States, 85308"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joie","family":"Rowles","sequence":"additional","affiliation":[{"name":"Midwestern University , , 19555 N. 59th Ave. , , ,","place":["Glendale, Arizona, United States, 85308"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"He","sequence":"additional","affiliation":[{"name":"University of Chicago , , 929 E. 57th St. , , ,","place":["Chicago, Illinois, United States, 60637"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Olsen","sequence":"additional","affiliation":[{"name":"Midwestern University , , 19555 N. 59th Ave. , , ,","place":["Glendale, Arizona, United States, 85308"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2014,5,18]]},"reference":[{"key":"2026090214220543000_cit1","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2174\/138955712802762266","article-title":"Perspectives on the\ndevelopment of antioxidant antiepileptogenic\nagents","volume":"12","author":"Rowles","year":"2012","journal-title":"Mini Rev. 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U.S.A."},{"key":"2026090214220543000_cit19","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1016\/j.bmcl.2006.08.040","article-title":"Structure-based design, synthesis,\nand SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1\u03b1\nprolyl hydroxylase inhibitors","volume":"16","author":"Warshakoon","year":"2006","journal-title":"Bioorg. Med.\nChem. Lett."},{"key":"2026090214220543000_cit20","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/hlca.19540370436","article-title":"Reductone. II. The\nisolation of 5-aryl-3-hydroxytetronimide from aromatic and heterocyclic-aromatic\naldehydes, glyoxal, and potassium cyanide","volume":"37","author":"Dahn","year":"1954","journal-title":"Helv.\nChim. 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Dis."},{"key":"2026090214220543000_cit25","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1074\/jbc.C200644200","article-title":"Structure\nof factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism\nof oxidative modification of HIF-1 alpha","volume":"278","author":"Elkins","year":"2003","journal-title":"J.\nBiol. Chem."},{"key":"2026090214220543000_cit26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature05971","article-title":"Crystal structures of histone demethylase JMJD2A reveal\nbasis for substrate specificity","volume":"448","author":"Ng","year":"2007","journal-title":"Nature"},{"key":"2026090214220543000_cit27","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/nature08921","article-title":"Crystal structure\nof the FTO protein reveals basis for its substrate specificity","volume":"464","author":"Han","year":"2010","journal-title":"Nature"},{"key":"2026090214220543000_cit28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine\nin nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"2026090214220543000_cit29","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1021\/jm400193d","article-title":"Structural\nbasis for inhibition of the fat mass and\nobesity associated protein (FTO)","volume":"56","author":"Aik","year":"2013","journal-title":"J. Med. Chem."},{"key":"2026090214220543000_cit30","doi-asserted-by":"crossref","first-page":"17963","DOI":"10.1021\/ja3064149","article-title":"Development\nof cell-active N6-methyladenosine RNA demethylase\nFTO inhibitor","volume":"134","author":"Chen","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"2026090214220543000_cit31","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1016\/j.febslet.2008.08.019","article-title":"Oxidative\ndemethylation of 3-methylthymine\nand 3-methyluracil in single-stranded DNA and RNA by mouse and human\nFTO","volume":"582","author":"Jia","year":"2008","journal-title":"FEBS Lett."},{"key":"2026090214220543000_cit32","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.4161\/epi.21977","article-title":"FTO, RNA epigenetics\nand epilepsy","volume":"7","author":"Rowles","year":"2012","journal-title":"Epigenetics"},{"key":"2026090214220543000_cit33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/10495390903381792","article-title":"Expression\nstudies\nof the obesity candidate gene FTO in pig","volume":"21","author":"Madsen","year":"2010","journal-title":"Anim.\nBiotechnol."},{"key":"2026090214220543000_cit34","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","article-title":"Comprehensive analysis\nof mRNA methylation reveals\nenrichment in 3\u2032 UTRs and near stop codons","volume":"149","author":"Meyer","year":"2012","journal-title":"Cell"},{"key":"2026090214220543000_cit35","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11112","article-title":"Topology of\nthe human and mouse m6A RNA methylomes revealed by m6A-seq","volume":"485","author":"Dominissini","year":"2012","journal-title":"Nature"},{"key":"2026090214220543000_cit36","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12035-011-8211-3","article-title":"Functions of noncoding RNAs in neural development and neurological\ndiseases","volume":"44","author":"Bian","year":"2011","journal-title":"Mol. 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U.S.A."},{"key":"2026090214220543000_cit40","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1360-0443.2010.03248.x","article-title":"Inverse association of the obesity\npredisposing FTO rs9939609 genotype with alcohol consumption and risk\nfor alcohol dependence","volume":"106","author":"Sobczyk-Kopciol","year":"2011","journal-title":"Addiction"},{"key":"2026090214220543000_cit41","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1172\/JCI44403","article-title":"A link\nbetween FTO, ghrelin, and impaired brain food-cue responsivity","volume":"123","author":"Karra","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2026090214220543000_cit42","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nn.3449","article-title":"The fat mass and obesity associated gene (FTO) regulates\nactivity of the dopaminergic midbrain circuitry","volume":"16","author":"Hess","year":"2013","journal-title":"Nat. Neurosci."},{"key":"2026090214220543000_cit43","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/00207454.2013.789513","article-title":"MicroRNA-based therapy: a new dimension in epilepsy\ntreatment","volume":"123","author":"Liu","year":"2013","journal-title":"Int. J. Neurosci."},{"key":"2026090214220543000_cit44","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1002\/hlca.19560390646","article-title":"Reductone. VII. Paper chromatography\nof 4-aryl-2-hydroxytetronimides\nand 5,6-diaryl-3,4,5-trihydroxy-5,6-dihydro-2-pyronimides","volume":"39","author":"Dahn","year":"1956","journal-title":"Helv. Chim. Acta"},{"key":"2026090214220543000_cit45","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1002\/anie.201001242","article-title":"The AlkB domain\nof mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine\nat the wobble position of tRNA","volume":"49","author":"Fu","year":"2010","journal-title":"Angew. Chem.,\nInt. Ed."}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/cn500042t","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/acncdm\/article-pdf\/5\/8\/658\/8625368\/cn500042t.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/acncdm\/article-pdf\/5\/8\/658\/8625368\/cn500042t.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:22:17Z","timestamp":1788373337000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/acncdm\/article\/5\/8\/658\/830746\/Synthesis-of-a-FTO-Inhibitor-with-Anticonvulsant"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,18]]},"references-count":45,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2014,5,18]]},"published-print":{"date-parts":[[2014,8,20]]}},"URL":"https:\/\/doi.org\/10.1021\/cn500042t","relation":{},"ISSN":["1948-7193"],"issn-type":[{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,18]]}}}